Oxidative stress in pregnant women with diabetes mellitus

Oxidative stress (OS) plays an important role in embryo development, implantation, placentation, fetal development and labour. Diabetes mellitus (DM) is associated with an increase in OS processes. However, the expression of OS biomarkers in pregnant women with DM remains unclear. Based on a literat...

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Autores principales:	Roman V. Kapustin, Olga N. Arzhanova, Alena V. Tiselko
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2017
Materias:	pregnancy diabetes mellitus oxidative stress reactive oxygen species Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/25a0a421a0b34354b2861b981198a6a3
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spelling	oai:doaj.org-article:25a0a421a0b34354b2861b981198a6a32021-11-14T09:00:21ZOxidative stress in pregnant women with diabetes mellitus2072-03512072-037810.14341/DM8669https://doaj.org/article/25a0a421a0b34354b2861b981198a6a32017-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8669https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Oxidative stress (OS) plays an important role in embryo development, implantation, placentation, fetal development and labour. Diabetes mellitus (DM) is associated with an increase in OS processes. However, the expression of OS biomarkers in pregnant women with DM remains unclear. Based on a literature review, the features of the pro- and anti-oxidant systems of pregnant women with different types of DM have been established. Pregnancy in patients with DM has been shown to be characterised by an activation of OS processes. This leads to an overexpression of free radicals (peroxynitrite), toxic derivatives (malonic dialdehyde, 8-isoprostane) and specific enzymes (asymmetric dimethylarginine, catalase) and a decrease in the synthesis of antioxidants (superoxide dismutase, glutathione peroxidase and uric acid). The modified expression of these biomarkers is observed both in the blood and the placenta of pregnant women. These disorders can cause an unfavourable course of pregnancy, abnormal development of the placenta and development of adverse perinatal outcomes in pregnant women with DM. Nevertheless, given the inconsistency of data obtained, further scientific studies are needed to clarify this issue.Roman V. KapustinOlga N. ArzhanovaAlena V. TiselkoEndocrinology Research Centrearticlepregnancydiabetes mellitusoxidative stressreactive oxygen speciesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 6, Pp 461-471 (2017)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	pregnancy diabetes mellitus oxidative stress reactive oxygen species Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	pregnancy diabetes mellitus oxidative stress reactive oxygen species Nutritional diseases. Deficiency diseases RC620-627 Roman V. Kapustin Olga N. Arzhanova Alena V. Tiselko Oxidative stress in pregnant women with diabetes mellitus
description	Oxidative stress (OS) plays an important role in embryo development, implantation, placentation, fetal development and labour. Diabetes mellitus (DM) is associated with an increase in OS processes. However, the expression of OS biomarkers in pregnant women with DM remains unclear. Based on a literature review, the features of the pro- and anti-oxidant systems of pregnant women with different types of DM have been established. Pregnancy in patients with DM has been shown to be characterised by an activation of OS processes. This leads to an overexpression of free radicals (peroxynitrite), toxic derivatives (malonic dialdehyde, 8-isoprostane) and specific enzymes (asymmetric dimethylarginine, catalase) and a decrease in the synthesis of antioxidants (superoxide dismutase, glutathione peroxidase and uric acid). The modified expression of these biomarkers is observed both in the blood and the placenta of pregnant women. These disorders can cause an unfavourable course of pregnancy, abnormal development of the placenta and development of adverse perinatal outcomes in pregnant women with DM. Nevertheless, given the inconsistency of data obtained, further scientific studies are needed to clarify this issue.
format	article
author	Roman V. Kapustin Olga N. Arzhanova Alena V. Tiselko
author_facet	Roman V. Kapustin Olga N. Arzhanova Alena V. Tiselko
author_sort	Roman V. Kapustin
title	Oxidative stress in pregnant women with diabetes mellitus
title_short	Oxidative stress in pregnant women with diabetes mellitus
title_full	Oxidative stress in pregnant women with diabetes mellitus
title_fullStr	Oxidative stress in pregnant women with diabetes mellitus
title_full_unstemmed	Oxidative stress in pregnant women with diabetes mellitus
title_sort	oxidative stress in pregnant women with diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2017
url	https://doaj.org/article/25a0a421a0b34354b2861b981198a6a3
work_keys_str_mv	AT romanvkapustin oxidativestressinpregnantwomenwithdiabetesmellitus AT olganarzhanova oxidativestressinpregnantwomenwithdiabetesmellitus AT alenavtiselko oxidativestressinpregnantwomenwithdiabetesmellitus
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Oxidative stress in pregnant women with diabetes mellitus

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