Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers

Neuroendocrine prostate cancers are very difficult to treat and often arise after androgen-deprivation therapy. Here the authors show that ADT activates CREB that acts by increasing EZH2 activity to promote neuroendocrine differentiation in prostate cancer, providing alternative avenues for therapy.

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Autores principales:	Yan Zhang, Dayong Zheng, Ting Zhou, Haiping Song, Mohit Hulsurkar, Ning Su, Ying Liu, Zheng Wang, Long Shao, Michael Ittmann, Martin Gleave, Huanxing Han, Feng Xu, Wangjun Liao, Hongbo Wang, Wenliang Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/25a7d86d01c14730b94ebc63e65d2641
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spelling	oai:doaj.org-article:25a7d86d01c14730b94ebc63e65d26412021-12-02T16:49:18ZAndrogen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers10.1038/s41467-018-06177-22041-1723https://doaj.org/article/25a7d86d01c14730b94ebc63e65d26412018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06177-2https://doaj.org/toc/2041-1723Neuroendocrine prostate cancers are very difficult to treat and often arise after androgen-deprivation therapy. Here the authors show that ADT activates CREB that acts by increasing EZH2 activity to promote neuroendocrine differentiation in prostate cancer, providing alternative avenues for therapy.Yan ZhangDayong ZhengTing ZhouHaiping SongMohit HulsurkarNing SuYing LiuZheng WangLong ShaoMichael IttmannMartin GleaveHuanxing HanFeng XuWangjun LiaoHongbo WangWenliang LiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yan Zhang Dayong Zheng Ting Zhou Haiping Song Mohit Hulsurkar Ning Su Ying Liu Zheng Wang Long Shao Michael Ittmann Martin Gleave Huanxing Han Feng Xu Wangjun Liao Hongbo Wang Wenliang Li Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers
description	Neuroendocrine prostate cancers are very difficult to treat and often arise after androgen-deprivation therapy. Here the authors show that ADT activates CREB that acts by increasing EZH2 activity to promote neuroendocrine differentiation in prostate cancer, providing alternative avenues for therapy.
format	article
author	Yan Zhang Dayong Zheng Ting Zhou Haiping Song Mohit Hulsurkar Ning Su Ying Liu Zheng Wang Long Shao Michael Ittmann Martin Gleave Huanxing Han Feng Xu Wangjun Liao Hongbo Wang Wenliang Li
author_facet	Yan Zhang Dayong Zheng Ting Zhou Haiping Song Mohit Hulsurkar Ning Su Ying Liu Zheng Wang Long Shao Michael Ittmann Martin Gleave Huanxing Han Feng Xu Wangjun Liao Hongbo Wang Wenliang Li
author_sort	Yan Zhang
title	Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers
title_short	Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers
title_full	Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers
title_fullStr	Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers
title_full_unstemmed	Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers
title_sort	androgen deprivation promotes neuroendocrine differentiation and angiogenesis through creb-ezh2-tsp1 pathway in prostate cancers
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/25a7d86d01c14730b94ebc63e65d2641
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Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers

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