The Dynamic Transition of Persistence toward the Viable but Nonculturable State during Stationary Phase Is Driven by Protein Aggregation

The Dynamic Transition of Persistence toward the Viable but Nonculturable State during Stationary Phase Is Driven by Protein Aggregation

ABSTRACT Decades of research into bacterial persistence has been unable to fully characterize this antibiotic-tolerant phenotype, thereby hampering the development of therapies effective against chronic infections. Although some active persister mechanisms have been identified, the prevailing view i...

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Autores principales: Liselot Dewachter, Celien Bollen, Dorien Wilmaerts, Elen Louwagie, Pauline Herpels, Paul Matthay, Ladan Khodaparast, Laleh Khodaparast, Frederic Rousseau, Joost Schymkowitz, Jan Michiels
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
protein aggregation
persistence
antibiotic tolerance
VBNC
dormancy
ObgE
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/25a864ad0b934f97852bf42dc666e337
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