Transgenerational inheritance of susceptibility to diabetes-induced male subfertility

Abstract Male infertility is a worldwide problem associated with genetic background, environmental factors, and diseases. One of the suspected contributing factors to male infertility is diabetes mellitus. We investigated the molecular and morphological changes in sperms and testicular tissue of dia...

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Autores principales:	Gabriela Pavlinkova, Hasmik Margaryan, Eva Zatecka, Eliska Valaskova, Fatima Elzeinova, Alena Kubatova, Romana Bohuslavova, Jana Peknicova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25a881a5807244a9bb3fa0574e731308
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spelling	oai:doaj.org-article:25a881a5807244a9bb3fa0574e7313082021-12-02T15:05:09ZTransgenerational inheritance of susceptibility to diabetes-induced male subfertility10.1038/s41598-017-05286-02045-2322https://doaj.org/article/25a881a5807244a9bb3fa0574e7313082017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05286-0https://doaj.org/toc/2045-2322Abstract Male infertility is a worldwide problem associated with genetic background, environmental factors, and diseases. One of the suspected contributing factors to male infertility is diabetes mellitus. We investigated the molecular and morphological changes in sperms and testicular tissue of diabetic males. The study was performed in streptozotocin-induced type 1 diabetes mouse model. Diabetes decreased sperm concentration and viability and increased sperm apoptosis. Changes in protamine 1/protamine 2 ratio indicated reduced sperm quality. The testicular tissue of diabetic males showed significant tissue damage, disruption of meiotic progression, and changes in the expression of genes encoding proteins important for spermiogenesis. Paternal diabetes altered sperm quality and expression pattern in the testes in offspring of two subsequent generations. Our study revealed that paternal diabetes increased susceptibility to infertility in offspring through gametic alternations. Our data also provide a mechanistic basis for transgenerational inheritance of diabetes-associated pathologies since protamines may be involved in epigenetic regulations.Gabriela PavlinkovaHasmik MargaryanEva ZateckaEliska ValaskovaFatima ElzeinovaAlena KubatovaRomana BohuslavovaJana PeknicovaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gabriela Pavlinkova Hasmik Margaryan Eva Zatecka Eliska Valaskova Fatima Elzeinova Alena Kubatova Romana Bohuslavova Jana Peknicova Transgenerational inheritance of susceptibility to diabetes-induced male subfertility
description	Abstract Male infertility is a worldwide problem associated with genetic background, environmental factors, and diseases. One of the suspected contributing factors to male infertility is diabetes mellitus. We investigated the molecular and morphological changes in sperms and testicular tissue of diabetic males. The study was performed in streptozotocin-induced type 1 diabetes mouse model. Diabetes decreased sperm concentration and viability and increased sperm apoptosis. Changes in protamine 1/protamine 2 ratio indicated reduced sperm quality. The testicular tissue of diabetic males showed significant tissue damage, disruption of meiotic progression, and changes in the expression of genes encoding proteins important for spermiogenesis. Paternal diabetes altered sperm quality and expression pattern in the testes in offspring of two subsequent generations. Our study revealed that paternal diabetes increased susceptibility to infertility in offspring through gametic alternations. Our data also provide a mechanistic basis for transgenerational inheritance of diabetes-associated pathologies since protamines may be involved in epigenetic regulations.
format	article
author	Gabriela Pavlinkova Hasmik Margaryan Eva Zatecka Eliska Valaskova Fatima Elzeinova Alena Kubatova Romana Bohuslavova Jana Peknicova
author_facet	Gabriela Pavlinkova Hasmik Margaryan Eva Zatecka Eliska Valaskova Fatima Elzeinova Alena Kubatova Romana Bohuslavova Jana Peknicova
author_sort	Gabriela Pavlinkova
title	Transgenerational inheritance of susceptibility to diabetes-induced male subfertility
title_short	Transgenerational inheritance of susceptibility to diabetes-induced male subfertility
title_full	Transgenerational inheritance of susceptibility to diabetes-induced male subfertility
title_fullStr	Transgenerational inheritance of susceptibility to diabetes-induced male subfertility
title_full_unstemmed	Transgenerational inheritance of susceptibility to diabetes-induced male subfertility
title_sort	transgenerational inheritance of susceptibility to diabetes-induced male subfertility
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/25a881a5807244a9bb3fa0574e731308
work_keys_str_mv	AT gabrielapavlinkova transgenerationalinheritanceofsusceptibilitytodiabetesinducedmalesubfertility AT hasmikmargaryan transgenerationalinheritanceofsusceptibilitytodiabetesinducedmalesubfertility AT evazatecka transgenerationalinheritanceofsusceptibilitytodiabetesinducedmalesubfertility AT eliskavalaskova transgenerationalinheritanceofsusceptibilitytodiabetesinducedmalesubfertility AT fatimaelzeinova transgenerationalinheritanceofsusceptibilitytodiabetesinducedmalesubfertility AT alenakubatova transgenerationalinheritanceofsusceptibilitytodiabetesinducedmalesubfertility AT romanabohuslavova transgenerationalinheritanceofsusceptibilitytodiabetesinducedmalesubfertility AT janapeknicova transgenerationalinheritanceofsusceptibilitytodiabetesinducedmalesubfertility
_version_	1718388878830731264

Transgenerational inheritance of susceptibility to diabetes-induced male subfertility

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