A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport
Centrosomes function as microtubule organizing centers where several mRNAs accumulate. By employing high-throughput single molecule FISH screening, the authors discover that 8 human mRNAs localize to centrosomes with unique cell cycle dependent patterns using an active polysome targeting mechanism.
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Nature Portfolio
2021
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oai:doaj.org-article:25ad29dc528349468528a16fc452a6aa2021-12-02T15:53:26ZA choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport10.1038/s41467-021-21585-72041-1723https://doaj.org/article/25ad29dc528349468528a16fc452a6aa2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21585-7https://doaj.org/toc/2041-1723Centrosomes function as microtubule organizing centers where several mRNAs accumulate. By employing high-throughput single molecule FISH screening, the authors discover that 8 human mRNAs localize to centrosomes with unique cell cycle dependent patterns using an active polysome targeting mechanism.Adham SafieddineEmeline ColenoSoha SalloumArthur ImbertAbdel-Meneem TraboulsiOh Sung KwonFrederic LionnetonVirginie GeorgetMarie-Cécile RobertThierry GostanCharles-Henri LecellierRacha ChouaibXavier PichonHervé Le HirKazem ZibaraFlorian MuellerThomas WalterMarion PeterEdouard BertrandNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Adham Safieddine Emeline Coleno Soha Salloum Arthur Imbert Abdel-Meneem Traboulsi Oh Sung Kwon Frederic Lionneton Virginie Georget Marie-Cécile Robert Thierry Gostan Charles-Henri Lecellier Racha Chouaib Xavier Pichon Hervé Le Hir Kazem Zibara Florian Mueller Thomas Walter Marion Peter Edouard Bertrand A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport |
| description |
Centrosomes function as microtubule organizing centers where several mRNAs accumulate. By employing high-throughput single molecule FISH screening, the authors discover that 8 human mRNAs localize to centrosomes with unique cell cycle dependent patterns using an active polysome targeting mechanism. |
| format |
article |
| author |
Adham Safieddine Emeline Coleno Soha Salloum Arthur Imbert Abdel-Meneem Traboulsi Oh Sung Kwon Frederic Lionneton Virginie Georget Marie-Cécile Robert Thierry Gostan Charles-Henri Lecellier Racha Chouaib Xavier Pichon Hervé Le Hir Kazem Zibara Florian Mueller Thomas Walter Marion Peter Edouard Bertrand |
| author_facet |
Adham Safieddine Emeline Coleno Soha Salloum Arthur Imbert Abdel-Meneem Traboulsi Oh Sung Kwon Frederic Lionneton Virginie Georget Marie-Cécile Robert Thierry Gostan Charles-Henri Lecellier Racha Chouaib Xavier Pichon Hervé Le Hir Kazem Zibara Florian Mueller Thomas Walter Marion Peter Edouard Bertrand |
| author_sort |
Adham Safieddine |
| title |
A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport |
| title_short |
A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport |
| title_full |
A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport |
| title_fullStr |
A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport |
| title_full_unstemmed |
A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport |
| title_sort |
choreography of centrosomal mrnas reveals a conserved localization mechanism involving active polysome transport |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/25ad29dc528349468528a16fc452a6aa |
| work_keys_str_mv |
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| _version_ |
1718385500344025088 |