Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis.

<h4>Background</h4>Coronary artery disease (CAD) is a leading cause of mortality in many countries. Considerable studies have been carried out to investigate the relationship between the C242T and A640G polymorphisms of CYBA gene and CAD, but the results were still inconsistent. Hence we...

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Autores principales:	Qiumei Xu, Fangfen Yuan, Xuemei Shen, Hui Wen, Wei Li, Bei Cheng, Jing Wu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25af3e2973e64d74bf18593a7881d732
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spelling	oai:doaj.org-article:25af3e2973e64d74bf18593a7881d7322021-11-18T08:39:07ZPolymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis.1932-620310.1371/journal.pone.0084251https://doaj.org/article/25af3e2973e64d74bf18593a7881d7322014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24392120/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Coronary artery disease (CAD) is a leading cause of mortality in many countries. Considerable studies have been carried out to investigate the relationship between the C242T and A640G polymorphisms of CYBA gene and CAD, but the results were still inconsistent. Hence we conducted a meta-analysis to clarify the association.<h4>Methods and results</h4>A total of 21 eligible literatures were included in the meta-analysis. We observed a significant decreased risk of CAD for C242T polymorphism in Asian population under an allelic model (OR 0.75; 95% CI 0.67-0.84) and a dominant model (OR 0.69; 95% CI 0.61-0.79), however, in overall population and other population no significant association was revealed. We also found A640G polymorphism may contribute to reducing CAD risk under an allelic model (OR 0.84; 95% CI 0.75-0.93), dominant model (OR0.77; 95% CI 0.64-0.92) and recessive model (OR0.82; 95% CI 0.69-0.97). No publication bias was found.<h4>Conclusion</h4>Our meta-analysis confirmed a protective effect of C242T polymorphism on CAD in Asian population and indicated that A640G polymorphism was significantly associated with decreased risk of CAD.Qiumei XuFangfen YuanXuemei ShenHui WenWei LiBei ChengJing WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e84251 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiumei Xu Fangfen Yuan Xuemei Shen Hui Wen Wei Li Bei Cheng Jing Wu Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis.
description	<h4>Background</h4>Coronary artery disease (CAD) is a leading cause of mortality in many countries. Considerable studies have been carried out to investigate the relationship between the C242T and A640G polymorphisms of CYBA gene and CAD, but the results were still inconsistent. Hence we conducted a meta-analysis to clarify the association.<h4>Methods and results</h4>A total of 21 eligible literatures were included in the meta-analysis. We observed a significant decreased risk of CAD for C242T polymorphism in Asian population under an allelic model (OR 0.75; 95% CI 0.67-0.84) and a dominant model (OR 0.69; 95% CI 0.61-0.79), however, in overall population and other population no significant association was revealed. We also found A640G polymorphism may contribute to reducing CAD risk under an allelic model (OR 0.84; 95% CI 0.75-0.93), dominant model (OR0.77; 95% CI 0.64-0.92) and recessive model (OR0.82; 95% CI 0.69-0.97). No publication bias was found.<h4>Conclusion</h4>Our meta-analysis confirmed a protective effect of C242T polymorphism on CAD in Asian population and indicated that A640G polymorphism was significantly associated with decreased risk of CAD.
format	article
author	Qiumei Xu Fangfen Yuan Xuemei Shen Hui Wen Wei Li Bei Cheng Jing Wu
author_facet	Qiumei Xu Fangfen Yuan Xuemei Shen Hui Wen Wei Li Bei Cheng Jing Wu
author_sort	Qiumei Xu
title	Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis.
title_short	Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis.
title_full	Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis.
title_fullStr	Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis.
title_full_unstemmed	Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis.
title_sort	polymorphisms of c242t and a640g in cyba gene and the risk of coronary artery disease: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/25af3e2973e64d74bf18593a7881d732
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Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis.

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