Impacts of Diverse Natural Products on Honey Bee Viral Loads and Health

Western honey bees (<i>Apis mellifera</i>), a cornerstone to crop pollination in the U.S., are faced with an onslaught of challenges from diseases caused by parasites, pathogens, and pests that affect this economically valuable pollinator. Natural products (NPs), produced by living organ...

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Autores principales:	Dawn L. Boncristiani, James P. Tauber, Evan C. Palmer-Young, Lianfei Cao, William Collins, Kyle Grubbs, Jillian A. Lopez, Lyndel W. Meinhardt, Vy Nguyen, Sungtaek Oh, Raymond J. Peterson, Halondra Zamora, Yanping Chen, Jay D. Evans
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	honey bee natural product disease antiviral health Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/25b1b710b3b64e93ad2c74414c27852d
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spelling	oai:doaj.org-article:25b1b710b3b64e93ad2c74414c27852d2021-11-25T16:36:52ZImpacts of Diverse Natural Products on Honey Bee Viral Loads and Health10.3390/app1122107322076-3417https://doaj.org/article/25b1b710b3b64e93ad2c74414c27852d2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10732https://doaj.org/toc/2076-3417Western honey bees (<i>Apis mellifera</i>), a cornerstone to crop pollination in the U.S., are faced with an onslaught of challenges from diseases caused by parasites, pathogens, and pests that affect this economically valuable pollinator. Natural products (NPs), produced by living organisms, including plants and microorganisms, can support health and combat disease in animals. NPs include both native extracts and individual compounds that can reduce disease impacts by supporting immunity or directly inhibiting pathogens, pests, and parasites. Herein, we describe the screening of NPs in laboratory cage studies for their effects on honey bee disease prevention and control. Depending on the expected activity of compounds, we measured varied responses, including viral levels, honey bee immune responses, and symbiotic bacteria loads. Of the NPs screened, several compounds demonstrated beneficial activities in honey bees by reducing levels of the critical honey bee virus deformed wing virus (DWV-A and-B), positively impacting the gut microbiome or stimulating honey bee immune responses. Investigations of the medicinal properties of NPs in honey bees will contribute to a better understanding of their potential to support honey bee immunity to fight off pests and pathogens and promote increased overall honey bee health. These investigations will also shed light on the ecological interactions between pollinators and specific floral food sources.Dawn L. BoncristianiJames P. TauberEvan C. Palmer-YoungLianfei CaoWilliam CollinsKyle GrubbsJillian A. LopezLyndel W. MeinhardtVy NguyenSungtaek OhRaymond J. PetersonHalondra ZamoraYanping ChenJay D. EvansMDPI AGarticlehoney beenatural productdiseaseantiviralhealthTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10732, p 10732 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	honey bee natural product disease antiviral health Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	honey bee natural product disease antiviral health Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Dawn L. Boncristiani James P. Tauber Evan C. Palmer-Young Lianfei Cao William Collins Kyle Grubbs Jillian A. Lopez Lyndel W. Meinhardt Vy Nguyen Sungtaek Oh Raymond J. Peterson Halondra Zamora Yanping Chen Jay D. Evans Impacts of Diverse Natural Products on Honey Bee Viral Loads and Health
description	Western honey bees (<i>Apis mellifera</i>), a cornerstone to crop pollination in the U.S., are faced with an onslaught of challenges from diseases caused by parasites, pathogens, and pests that affect this economically valuable pollinator. Natural products (NPs), produced by living organisms, including plants and microorganisms, can support health and combat disease in animals. NPs include both native extracts and individual compounds that can reduce disease impacts by supporting immunity or directly inhibiting pathogens, pests, and parasites. Herein, we describe the screening of NPs in laboratory cage studies for their effects on honey bee disease prevention and control. Depending on the expected activity of compounds, we measured varied responses, including viral levels, honey bee immune responses, and symbiotic bacteria loads. Of the NPs screened, several compounds demonstrated beneficial activities in honey bees by reducing levels of the critical honey bee virus deformed wing virus (DWV-A and-B), positively impacting the gut microbiome or stimulating honey bee immune responses. Investigations of the medicinal properties of NPs in honey bees will contribute to a better understanding of their potential to support honey bee immunity to fight off pests and pathogens and promote increased overall honey bee health. These investigations will also shed light on the ecological interactions between pollinators and specific floral food sources.
format	article
author	Dawn L. Boncristiani James P. Tauber Evan C. Palmer-Young Lianfei Cao William Collins Kyle Grubbs Jillian A. Lopez Lyndel W. Meinhardt Vy Nguyen Sungtaek Oh Raymond J. Peterson Halondra Zamora Yanping Chen Jay D. Evans
author_facet	Dawn L. Boncristiani James P. Tauber Evan C. Palmer-Young Lianfei Cao William Collins Kyle Grubbs Jillian A. Lopez Lyndel W. Meinhardt Vy Nguyen Sungtaek Oh Raymond J. Peterson Halondra Zamora Yanping Chen Jay D. Evans
author_sort	Dawn L. Boncristiani
title	Impacts of Diverse Natural Products on Honey Bee Viral Loads and Health
title_short	Impacts of Diverse Natural Products on Honey Bee Viral Loads and Health
title_full	Impacts of Diverse Natural Products on Honey Bee Viral Loads and Health
title_fullStr	Impacts of Diverse Natural Products on Honey Bee Viral Loads and Health
title_full_unstemmed	Impacts of Diverse Natural Products on Honey Bee Viral Loads and Health
title_sort	impacts of diverse natural products on honey bee viral loads and health
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/25b1b710b3b64e93ad2c74414c27852d
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Impacts of Diverse Natural Products on Honey Bee Viral Loads and Health

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