Evaluation of overall survival and barriers to surgery for patients with breast cancer treated without surgery: a National Cancer Database analysis

Abstract Surgery remains the foundation of curative therapy for non-metastatic breast cancer, but many patients do not undergo surgery. Evidence is limited regarding this population. We sought to assess factors associated with lack of surgery and overall survival (OS) in patients not receiving breas...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: D. Boyce-Fappiano, I. Bedrosian, Y. Shen, H. Lin, O. Gjyshi, A. Yoder, S. F. Shaitelman, W. A. Woodward
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Acceso en línea:https://doaj.org/article/25b3a7317329441ebee89d886e0fa1c3
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:25b3a7317329441ebee89d886e0fa1c3
record_format dspace
spelling oai:doaj.org-article:25b3a7317329441ebee89d886e0fa1c32021-12-02T15:23:18ZEvaluation of overall survival and barriers to surgery for patients with breast cancer treated without surgery: a National Cancer Database analysis10.1038/s41523-021-00294-w2374-4677https://doaj.org/article/25b3a7317329441ebee89d886e0fa1c32021-07-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00294-whttps://doaj.org/toc/2374-4677Abstract Surgery remains the foundation of curative therapy for non-metastatic breast cancer, but many patients do not undergo surgery. Evidence is limited regarding this population. We sought to assess factors associated with lack of surgery and overall survival (OS) in patients not receiving breast cancer surgery. Retrospective cohort study of patients in the US National Cancer Database treated in 2004–2016. The dataset comprised 2,696,734 patients; excluding patients with unknown surgical status or stage IV, cT0, cTx, or pIS, metastatic or recurrent disease resulted in 1,192,294 patients for analysis. Chi-square and Wilcoxon rank-sum tests were used to assess differences between groups. OS was analyzed using the Kaplan–Meier method with a Cox proportional hazards model performed to assess associated factors. In total 50,626 (4.3%) did not undergo surgery. Black race, age >50 years, lower income, uninsured or public insurance, and lower education were more prevalent in the non-surgical cohort; this group was also more likely to have more comorbidities, higher disease stage, and more aggressive disease biology. Only 3,689 non-surgical patients (7.3%) received radiation therapy (RT). Median OS time for the non-surgical patients was 58 months (3-year and 5-year OS rates 63% and 49%). Median OS times were longer for patients who received chemotherapy (80 vs 50 (no-chemo) months) and RT (85 vs 56 (no-RT) months). On multivariate analysis, age, race, income, insurance status, comorbidity score, disease stage, tumor subtype, treatment facility type and location, and receipt of RT were associated with OS. On subgroup analysis, receipt of chemotherapy improved OS for patients with triple negative (HR 0.66, 95% CI 0.59–0.75, P < 0.001) and HER2+ (HR 0.74, 95% CI 0.65–0.84, P < 0.001) subgroups while RT improved OS for ER+ (HR 0.72, 95% CI 0.64–0.82, P < 0.001) and favorable-disease (ER+, early-stage, age >60) (HR 0.61, 95% CI 0.45–0.83, P = 0.002) subgroups. Approximately 4% of women with breast cancer do not undergo surgery, particularly those with more aggressive disease and lower socioeconomic status. Despite its benefits, RT was underutilized. This study provides a benchmark of survival outcomes for patients who do not undergo surgery and highlights a potential role for use of RT.D. Boyce-FappianoI. BedrosianY. ShenH. LinO. GjyshiA. YoderS. F. ShaitelmanW. A. WoodwardNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
D. Boyce-Fappiano
I. Bedrosian
Y. Shen
H. Lin
O. Gjyshi
A. Yoder
S. F. Shaitelman
W. A. Woodward
Evaluation of overall survival and barriers to surgery for patients with breast cancer treated without surgery: a National Cancer Database analysis
description Abstract Surgery remains the foundation of curative therapy for non-metastatic breast cancer, but many patients do not undergo surgery. Evidence is limited regarding this population. We sought to assess factors associated with lack of surgery and overall survival (OS) in patients not receiving breast cancer surgery. Retrospective cohort study of patients in the US National Cancer Database treated in 2004–2016. The dataset comprised 2,696,734 patients; excluding patients with unknown surgical status or stage IV, cT0, cTx, or pIS, metastatic or recurrent disease resulted in 1,192,294 patients for analysis. Chi-square and Wilcoxon rank-sum tests were used to assess differences between groups. OS was analyzed using the Kaplan–Meier method with a Cox proportional hazards model performed to assess associated factors. In total 50,626 (4.3%) did not undergo surgery. Black race, age >50 years, lower income, uninsured or public insurance, and lower education were more prevalent in the non-surgical cohort; this group was also more likely to have more comorbidities, higher disease stage, and more aggressive disease biology. Only 3,689 non-surgical patients (7.3%) received radiation therapy (RT). Median OS time for the non-surgical patients was 58 months (3-year and 5-year OS rates 63% and 49%). Median OS times were longer for patients who received chemotherapy (80 vs 50 (no-chemo) months) and RT (85 vs 56 (no-RT) months). On multivariate analysis, age, race, income, insurance status, comorbidity score, disease stage, tumor subtype, treatment facility type and location, and receipt of RT were associated with OS. On subgroup analysis, receipt of chemotherapy improved OS for patients with triple negative (HR 0.66, 95% CI 0.59–0.75, P < 0.001) and HER2+ (HR 0.74, 95% CI 0.65–0.84, P < 0.001) subgroups while RT improved OS for ER+ (HR 0.72, 95% CI 0.64–0.82, P < 0.001) and favorable-disease (ER+, early-stage, age >60) (HR 0.61, 95% CI 0.45–0.83, P = 0.002) subgroups. Approximately 4% of women with breast cancer do not undergo surgery, particularly those with more aggressive disease and lower socioeconomic status. Despite its benefits, RT was underutilized. This study provides a benchmark of survival outcomes for patients who do not undergo surgery and highlights a potential role for use of RT.
format article
author D. Boyce-Fappiano
I. Bedrosian
Y. Shen
H. Lin
O. Gjyshi
A. Yoder
S. F. Shaitelman
W. A. Woodward
author_facet D. Boyce-Fappiano
I. Bedrosian
Y. Shen
H. Lin
O. Gjyshi
A. Yoder
S. F. Shaitelman
W. A. Woodward
author_sort D. Boyce-Fappiano
title Evaluation of overall survival and barriers to surgery for patients with breast cancer treated without surgery: a National Cancer Database analysis
title_short Evaluation of overall survival and barriers to surgery for patients with breast cancer treated without surgery: a National Cancer Database analysis
title_full Evaluation of overall survival and barriers to surgery for patients with breast cancer treated without surgery: a National Cancer Database analysis
title_fullStr Evaluation of overall survival and barriers to surgery for patients with breast cancer treated without surgery: a National Cancer Database analysis
title_full_unstemmed Evaluation of overall survival and barriers to surgery for patients with breast cancer treated without surgery: a National Cancer Database analysis
title_sort evaluation of overall survival and barriers to surgery for patients with breast cancer treated without surgery: a national cancer database analysis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/25b3a7317329441ebee89d886e0fa1c3
work_keys_str_mv AT dboycefappiano evaluationofoverallsurvivalandbarrierstosurgeryforpatientswithbreastcancertreatedwithoutsurgeryanationalcancerdatabaseanalysis
AT ibedrosian evaluationofoverallsurvivalandbarrierstosurgeryforpatientswithbreastcancertreatedwithoutsurgeryanationalcancerdatabaseanalysis
AT yshen evaluationofoverallsurvivalandbarrierstosurgeryforpatientswithbreastcancertreatedwithoutsurgeryanationalcancerdatabaseanalysis
AT hlin evaluationofoverallsurvivalandbarrierstosurgeryforpatientswithbreastcancertreatedwithoutsurgeryanationalcancerdatabaseanalysis
AT ogjyshi evaluationofoverallsurvivalandbarrierstosurgeryforpatientswithbreastcancertreatedwithoutsurgeryanationalcancerdatabaseanalysis
AT ayoder evaluationofoverallsurvivalandbarrierstosurgeryforpatientswithbreastcancertreatedwithoutsurgeryanationalcancerdatabaseanalysis
AT sfshaitelman evaluationofoverallsurvivalandbarrierstosurgeryforpatientswithbreastcancertreatedwithoutsurgeryanationalcancerdatabaseanalysis
AT wawoodward evaluationofoverallsurvivalandbarrierstosurgeryforpatientswithbreastcancertreatedwithoutsurgeryanationalcancerdatabaseanalysis
_version_ 1718387250534809600