Synthesis and Characterization of Multifunctional Nanovesicles Composed of POPC Lipid Molecules for Nuclear Imaging

The integration of nuclear imaging analysis with nanomedicine has tremendously grown and represents a valid and powerful tool for the development and clinical translation of drug delivery systems. Among the various types of nanostructures used as drug carriers, nanovesicles represent intriguing plat...

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Autores principales:	Debora Petroni, Claudia Riccardi, Domenico Cavasso, Irene Russo Krauss, Luigi Paduano, Daniela Montesarchio, Luca Menichetti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	liposome PET gallium-68 drug delivery POPC NOTA Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/25b521bfc5be42f292cf697d0db72874
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spelling	oai:doaj.org-article:25b521bfc5be42f292cf697d0db728742021-11-11T18:34:02ZSynthesis and Characterization of Multifunctional Nanovesicles Composed of POPC Lipid Molecules for Nuclear Imaging10.3390/molecules262165911420-3049https://doaj.org/article/25b521bfc5be42f292cf697d0db728742021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6591https://doaj.org/toc/1420-3049The integration of nuclear imaging analysis with nanomedicine has tremendously grown and represents a valid and powerful tool for the development and clinical translation of drug delivery systems. Among the various types of nanostructures used as drug carriers, nanovesicles represent intriguing platforms due to their capability to entrap both lipophilic and hydrophilic agents, and their well-known biocompatibility and biodegradability. In this respect, here we present the development of a labelling procedure of POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine)-based liposomes incorporating an ad hoc designed lipophilic NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) analogue, derivatized with an oleic acid residue, able to bind the positron emitter gallium-68(III). Based on POPC features, the optimal conditions for liposome labelling were studied with the aim of optimizing the Ga(III) incorporation and obtaining a significant radiochemical yield. The data presented in this work demonstrate the feasibility of the labelling procedure on POPC liposomes co-formulated with the ad hoc designed NOTA analogue. We thus provided a critical insight into the practical aspects of the development of vesicles for theranostic approaches, which in principle can be extended to other nanosystems exploiting a variety of bioconjugation protocols.Debora PetroniClaudia RiccardiDomenico CavassoIrene Russo KraussLuigi PaduanoDaniela MontesarchioLuca MenichettiMDPI AGarticleliposomePETgallium-68drug deliveryPOPCNOTAOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6591, p 6591 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liposome PET gallium-68 drug delivery POPC NOTA Organic chemistry QD241-441
spellingShingle	liposome PET gallium-68 drug delivery POPC NOTA Organic chemistry QD241-441 Debora Petroni Claudia Riccardi Domenico Cavasso Irene Russo Krauss Luigi Paduano Daniela Montesarchio Luca Menichetti Synthesis and Characterization of Multifunctional Nanovesicles Composed of POPC Lipid Molecules for Nuclear Imaging
description	The integration of nuclear imaging analysis with nanomedicine has tremendously grown and represents a valid and powerful tool for the development and clinical translation of drug delivery systems. Among the various types of nanostructures used as drug carriers, nanovesicles represent intriguing platforms due to their capability to entrap both lipophilic and hydrophilic agents, and their well-known biocompatibility and biodegradability. In this respect, here we present the development of a labelling procedure of POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine)-based liposomes incorporating an ad hoc designed lipophilic NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) analogue, derivatized with an oleic acid residue, able to bind the positron emitter gallium-68(III). Based on POPC features, the optimal conditions for liposome labelling were studied with the aim of optimizing the Ga(III) incorporation and obtaining a significant radiochemical yield. The data presented in this work demonstrate the feasibility of the labelling procedure on POPC liposomes co-formulated with the ad hoc designed NOTA analogue. We thus provided a critical insight into the practical aspects of the development of vesicles for theranostic approaches, which in principle can be extended to other nanosystems exploiting a variety of bioconjugation protocols.
format	article
author	Debora Petroni Claudia Riccardi Domenico Cavasso Irene Russo Krauss Luigi Paduano Daniela Montesarchio Luca Menichetti
author_facet	Debora Petroni Claudia Riccardi Domenico Cavasso Irene Russo Krauss Luigi Paduano Daniela Montesarchio Luca Menichetti
author_sort	Debora Petroni
title	Synthesis and Characterization of Multifunctional Nanovesicles Composed of POPC Lipid Molecules for Nuclear Imaging
title_short	Synthesis and Characterization of Multifunctional Nanovesicles Composed of POPC Lipid Molecules for Nuclear Imaging
title_full	Synthesis and Characterization of Multifunctional Nanovesicles Composed of POPC Lipid Molecules for Nuclear Imaging
title_fullStr	Synthesis and Characterization of Multifunctional Nanovesicles Composed of POPC Lipid Molecules for Nuclear Imaging
title_full_unstemmed	Synthesis and Characterization of Multifunctional Nanovesicles Composed of POPC Lipid Molecules for Nuclear Imaging
title_sort	synthesis and characterization of multifunctional nanovesicles composed of popc lipid molecules for nuclear imaging
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/25b521bfc5be42f292cf697d0db72874
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Synthesis and Characterization of Multifunctional Nanovesicles Composed of POPC Lipid Molecules for Nuclear Imaging

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