Targeting Mitochondria by Plant Secondary Metabolites: A Promising Strategy in Combating Parkinson’s Disease

Parkinson’s disease (PD) is one of the most prevalent and debilitating neurodegenerative conditions, and is currently on the rise. Several dysregulated pathways are behind the pathogenesis of PD; however, the critical targets remain unclear. Accordingly, there is an urgent need to reveal the key dys...

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Autores principales:	Sajad Fakhri, Sadaf Abdian, Seyede Nazanin Zarneshan, Esra Küpeli Akkol, Mohammad Hosein Farzaei, Eduardo Sobarzo-Sánchez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neurodegenerative disease Parkinson’s disease secondary metabolites phytochemicals mitochondria signaling pathway Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/25b65ef61a344aacaff75c0375d72c64
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spelling	oai:doaj.org-article:25b65ef61a344aacaff75c0375d72c642021-11-25T17:57:59ZTargeting Mitochondria by Plant Secondary Metabolites: A Promising Strategy in Combating Parkinson’s Disease10.3390/ijms2222125701422-00671661-6596https://doaj.org/article/25b65ef61a344aacaff75c0375d72c642021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12570https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Parkinson’s disease (PD) is one of the most prevalent and debilitating neurodegenerative conditions, and is currently on the rise. Several dysregulated pathways are behind the pathogenesis of PD; however, the critical targets remain unclear. Accordingly, there is an urgent need to reveal the key dysregulated pathways in PD. Prevailing reports have highlighted the importance of mitochondrial and cross-talked mediators in neurological disorders, genetic changes, and related complications of PD. Multiple pathophysiological mechanisms of PD, as well as the low efficacy and side effects of conventional neuroprotective therapies, drive the need for finding novel alternative agents. Recently, much attention has been paid to using plant secondary metabolites (e.g., flavonoids/phenolic compounds, alkaloids, and terpenoids) in the modulation of PD-associated manifestations by targeting mitochondria. In this line, plant secondary metabolites have shown promising potential for the simultaneous modulation of mitochondrial apoptosis and reactive oxygen species. This review aimed to address mitochondria and multiple dysregulated pathways in PD by plant-derived secondary metabolites.Sajad FakhriSadaf AbdianSeyede Nazanin ZarneshanEsra Küpeli AkkolMohammad Hosein FarzaeiEduardo Sobarzo-SánchezMDPI AGarticleneurodegenerative diseaseParkinson’s diseasesecondary metabolitesphytochemicalsmitochondriasignaling pathwayBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12570, p 12570 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurodegenerative disease Parkinson’s disease secondary metabolites phytochemicals mitochondria signaling pathway Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	neurodegenerative disease Parkinson’s disease secondary metabolites phytochemicals mitochondria signaling pathway Biology (General) QH301-705.5 Chemistry QD1-999 Sajad Fakhri Sadaf Abdian Seyede Nazanin Zarneshan Esra Küpeli Akkol Mohammad Hosein Farzaei Eduardo Sobarzo-Sánchez Targeting Mitochondria by Plant Secondary Metabolites: A Promising Strategy in Combating Parkinson’s Disease
description	Parkinson’s disease (PD) is one of the most prevalent and debilitating neurodegenerative conditions, and is currently on the rise. Several dysregulated pathways are behind the pathogenesis of PD; however, the critical targets remain unclear. Accordingly, there is an urgent need to reveal the key dysregulated pathways in PD. Prevailing reports have highlighted the importance of mitochondrial and cross-talked mediators in neurological disorders, genetic changes, and related complications of PD. Multiple pathophysiological mechanisms of PD, as well as the low efficacy and side effects of conventional neuroprotective therapies, drive the need for finding novel alternative agents. Recently, much attention has been paid to using plant secondary metabolites (e.g., flavonoids/phenolic compounds, alkaloids, and terpenoids) in the modulation of PD-associated manifestations by targeting mitochondria. In this line, plant secondary metabolites have shown promising potential for the simultaneous modulation of mitochondrial apoptosis and reactive oxygen species. This review aimed to address mitochondria and multiple dysregulated pathways in PD by plant-derived secondary metabolites.
format	article
author	Sajad Fakhri Sadaf Abdian Seyede Nazanin Zarneshan Esra Küpeli Akkol Mohammad Hosein Farzaei Eduardo Sobarzo-Sánchez
author_facet	Sajad Fakhri Sadaf Abdian Seyede Nazanin Zarneshan Esra Küpeli Akkol Mohammad Hosein Farzaei Eduardo Sobarzo-Sánchez
author_sort	Sajad Fakhri
title	Targeting Mitochondria by Plant Secondary Metabolites: A Promising Strategy in Combating Parkinson’s Disease
title_short	Targeting Mitochondria by Plant Secondary Metabolites: A Promising Strategy in Combating Parkinson’s Disease
title_full	Targeting Mitochondria by Plant Secondary Metabolites: A Promising Strategy in Combating Parkinson’s Disease
title_fullStr	Targeting Mitochondria by Plant Secondary Metabolites: A Promising Strategy in Combating Parkinson’s Disease
title_full_unstemmed	Targeting Mitochondria by Plant Secondary Metabolites: A Promising Strategy in Combating Parkinson’s Disease
title_sort	targeting mitochondria by plant secondary metabolites: a promising strategy in combating parkinson’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/25b65ef61a344aacaff75c0375d72c64
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Targeting Mitochondria by Plant Secondary Metabolites: A Promising Strategy in Combating Parkinson’s Disease

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