Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study.

<h4>Background</h4>Clinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe clinical characteristics and outcomes in a cohort of patients hospitalized with SARS-CoV-2 in Argentina.<h4>Methods</h4>Multicenter...

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Autores principales:	Ezequiel Cordova, Analia Mykietiuk, Omar Sued, Lautaro De Vedia, Natalia Pacifico, Matias H Garcia Hernandez, Natalia M Baeza, Franco Garibaldi, Maria Fernanda Alzogaray, Rosa Contreras, Lucrecia Soler Puy, Pablo G Scapellato, Laura Barcelona, Mariana L Golikow, Maria Florencia Piñeiro, Hugo J Miño, Maria Fernanda Consalvo, Corina Nemirovsky, Marisa Sanchez, Myrna Cabral, Lucia Lamponi Tappata, Mariano Blasco, Jamile Ballivian, Gustavo Lopardo, Martin E Stryjewski, ECCOVID study group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25b949e11ada4cab8aa60c5868abcbea
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spelling	oai:doaj.org-article:25b949e11ada4cab8aa60c5868abcbea2021-11-25T05:54:12ZClinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study.1932-620310.1371/journal.pone.0258260https://doaj.org/article/25b949e11ada4cab8aa60c5868abcbea2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258260https://doaj.org/toc/1932-6203<h4>Background</h4>Clinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe clinical characteristics and outcomes in a cohort of patients hospitalized with SARS-CoV-2 in Argentina.<h4>Methods</h4>Multicenter prospective cohort study of ≥18 years-old patients with confirmed SARS-CoV-2 infection consecutively admitted to 19 hospitals in Argentina. Multivariable logistic regression models were used to identify variables associated with 30-day mortality and admission to intensive care unit (ICU).<h4>Results</h4>A total of 809 patients were analyzed. Median age was 53 years, 56% were males and 71% had at least one comorbidity. The most common comorbidities were hypertension (32%), obesity (23%) and diabetes (17%). Disease severity at admission was classified as mild 25%, moderate 51%, severe 17%, and critical 7%. Almost half of patients (49%) required supplemental oxygen, 18% ICU, and 12% invasive ventilation. Overall, 30-day mortality was 11%. Factors independently associated with ICU admission were male gender (OR 1.81; 95%CI 1.16-2.81), hypertension (OR 3.21; 95%CI 2.08-4.95), obesity (OR 2.38; 95%CI 1.51-3.7), oxygen saturation ≤93% (OR 6.45; 95%CI 4.20-9.92) and lymphopenia (OR 3.21; 95%CI 2.08-4.95). Factors independently associated with 30-day mortality included age ≥60 years-old (OR 2.68; 95% CI 1.63-4.43), oxygen saturation ≤93% (OR 3.19; 95%CI 1.97-5.16) and lymphopenia (OR 2.65; 95%CI 1.64-4.27).<h4>Conclusions</h4>This cohort validates crucial clinical data on patients hospitalized with SARS-CoV-2 in Argentina.Ezequiel CordovaAnalia MykietiukOmar SuedLautaro De VediaNatalia PacificoMatias H Garcia HernandezNatalia M BaezaFranco GaribaldiMaria Fernanda AlzogarayRosa ContrerasLucrecia Soler PuyPablo G ScapellatoLaura BarcelonaMariana L GolikowMaria Florencia PiñeiroHugo J MiñoMaria Fernanda ConsalvoCorina NemirovskyMarisa SanchezMyrna CabralLucia Lamponi TappataMariano BlascoJamile BallivianGustavo LopardoMartin E StryjewskiECCOVID study groupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258260 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ezequiel Cordova Analia Mykietiuk Omar Sued Lautaro De Vedia Natalia Pacifico Matias H Garcia Hernandez Natalia M Baeza Franco Garibaldi Maria Fernanda Alzogaray Rosa Contreras Lucrecia Soler Puy Pablo G Scapellato Laura Barcelona Mariana L Golikow Maria Florencia Piñeiro Hugo J Miño Maria Fernanda Consalvo Corina Nemirovsky Marisa Sanchez Myrna Cabral Lucia Lamponi Tappata Mariano Blasco Jamile Ballivian Gustavo Lopardo Martin E Stryjewski ECCOVID study group Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study.
description	<h4>Background</h4>Clinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe clinical characteristics and outcomes in a cohort of patients hospitalized with SARS-CoV-2 in Argentina.<h4>Methods</h4>Multicenter prospective cohort study of ≥18 years-old patients with confirmed SARS-CoV-2 infection consecutively admitted to 19 hospitals in Argentina. Multivariable logistic regression models were used to identify variables associated with 30-day mortality and admission to intensive care unit (ICU).<h4>Results</h4>A total of 809 patients were analyzed. Median age was 53 years, 56% were males and 71% had at least one comorbidity. The most common comorbidities were hypertension (32%), obesity (23%) and diabetes (17%). Disease severity at admission was classified as mild 25%, moderate 51%, severe 17%, and critical 7%. Almost half of patients (49%) required supplemental oxygen, 18% ICU, and 12% invasive ventilation. Overall, 30-day mortality was 11%. Factors independently associated with ICU admission were male gender (OR 1.81; 95%CI 1.16-2.81), hypertension (OR 3.21; 95%CI 2.08-4.95), obesity (OR 2.38; 95%CI 1.51-3.7), oxygen saturation ≤93% (OR 6.45; 95%CI 4.20-9.92) and lymphopenia (OR 3.21; 95%CI 2.08-4.95). Factors independently associated with 30-day mortality included age ≥60 years-old (OR 2.68; 95% CI 1.63-4.43), oxygen saturation ≤93% (OR 3.19; 95%CI 1.97-5.16) and lymphopenia (OR 2.65; 95%CI 1.64-4.27).<h4>Conclusions</h4>This cohort validates crucial clinical data on patients hospitalized with SARS-CoV-2 in Argentina.
format	article
author	Ezequiel Cordova Analia Mykietiuk Omar Sued Lautaro De Vedia Natalia Pacifico Matias H Garcia Hernandez Natalia M Baeza Franco Garibaldi Maria Fernanda Alzogaray Rosa Contreras Lucrecia Soler Puy Pablo G Scapellato Laura Barcelona Mariana L Golikow Maria Florencia Piñeiro Hugo J Miño Maria Fernanda Consalvo Corina Nemirovsky Marisa Sanchez Myrna Cabral Lucia Lamponi Tappata Mariano Blasco Jamile Ballivian Gustavo Lopardo Martin E Stryjewski ECCOVID study group
author_facet	Ezequiel Cordova Analia Mykietiuk Omar Sued Lautaro De Vedia Natalia Pacifico Matias H Garcia Hernandez Natalia M Baeza Franco Garibaldi Maria Fernanda Alzogaray Rosa Contreras Lucrecia Soler Puy Pablo G Scapellato Laura Barcelona Mariana L Golikow Maria Florencia Piñeiro Hugo J Miño Maria Fernanda Consalvo Corina Nemirovsky Marisa Sanchez Myrna Cabral Lucia Lamponi Tappata Mariano Blasco Jamile Ballivian Gustavo Lopardo Martin E Stryjewski ECCOVID study group
author_sort	Ezequiel Cordova
title	Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study.
title_short	Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study.
title_full	Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study.
title_fullStr	Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study.
title_full_unstemmed	Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study.
title_sort	clinical characteristics and outcomes of hospitalized patients with sars-cov-2 infection in a latin american country: results from the eccovid multicenter prospective study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/25b949e11ada4cab8aa60c5868abcbea
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Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study.

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