Leptin resistance: underlying mechanisms and diagnosis

Olga Gruzdeva,1,2 Daria Borodkina,3 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Barbarash1,2 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation; 2Federal State Budget Educational Institution of Higher Education, Kemerovo St...

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Auteurs principaux:	Gruzdeva O, Borodkina D, Uchasova E, Dyleva Y, Barbarash O
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2019
Sujets:	leptin leptin resistance soluble leptin receptor Specialties of internal medicine RC581-951
Accès en ligne:	https://doaj.org/article/25b9ea4fc8a84d80b1ed96fc5f1f6cde
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spelling	oai:doaj.org-article:25b9ea4fc8a84d80b1ed96fc5f1f6cde2021-12-02T01:39:40ZLeptin resistance: underlying mechanisms and diagnosis1178-7007https://doaj.org/article/25b9ea4fc8a84d80b1ed96fc5f1f6cde2019-01-01T00:00:00Zhttps://www.dovepress.com/leptin-resistance-underlying-mechanisms-and-diagnosis-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Olga Gruzdeva,1,2 Daria Borodkina,3 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Barbarash1,2 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation; 2Federal State Budget Educational Institution of Higher Education, Kemerovo State Medical University of the Ministry of Healthcare of the Russian Federation, Kemerovo, Russian Federation; 3Autonomous Public Healthcare Institution of the Kemrovo Region, Kemerovo Regional Clinical Hospital Named After S.V. Beliyaev, Regional Center for Diabetes, Kemerovo, Russian Federation Abstract: Leptin and its receptors have been identified as key regulators of body weight and energy homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity and metabolic disorders, such as insulin resistance and dyslipidemia. Mechanisms underlying the development of leptin resistance include mutations in the genes encoding leptin and its receptors, as well as proteins involved in self-regulation of leptin synthesis and blood–brain barrier permeability. Leptin resistance encompasses a complex pathophysiological phenomenon with a number of potential research lines. In this review, we analyze the existing data on the methods used to diagnose leptin resistance. Keywords: leptin, leptin resistance, soluble leptin receptorGruzdeva OBorodkina DUchasova EDyleva YBarbarash ODove Medical Pressarticleleptinleptin resistancesoluble leptin receptorSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 191-198 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	leptin leptin resistance soluble leptin receptor Specialties of internal medicine RC581-951
spellingShingle	leptin leptin resistance soluble leptin receptor Specialties of internal medicine RC581-951 Gruzdeva O Borodkina D Uchasova E Dyleva Y Barbarash O Leptin resistance: underlying mechanisms and diagnosis
description	Olga Gruzdeva,1,2 Daria Borodkina,3 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Barbarash1,2 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation; 2Federal State Budget Educational Institution of Higher Education, Kemerovo State Medical University of the Ministry of Healthcare of the Russian Federation, Kemerovo, Russian Federation; 3Autonomous Public Healthcare Institution of the Kemrovo Region, Kemerovo Regional Clinical Hospital Named After S.V. Beliyaev, Regional Center for Diabetes, Kemerovo, Russian Federation Abstract: Leptin and its receptors have been identified as key regulators of body weight and energy homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity and metabolic disorders, such as insulin resistance and dyslipidemia. Mechanisms underlying the development of leptin resistance include mutations in the genes encoding leptin and its receptors, as well as proteins involved in self-regulation of leptin synthesis and blood–brain barrier permeability. Leptin resistance encompasses a complex pathophysiological phenomenon with a number of potential research lines. In this review, we analyze the existing data on the methods used to diagnose leptin resistance. Keywords: leptin, leptin resistance, soluble leptin receptor
format	article
author	Gruzdeva O Borodkina D Uchasova E Dyleva Y Barbarash O
author_facet	Gruzdeva O Borodkina D Uchasova E Dyleva Y Barbarash O
author_sort	Gruzdeva O
title	Leptin resistance: underlying mechanisms and diagnosis
title_short	Leptin resistance: underlying mechanisms and diagnosis
title_full	Leptin resistance: underlying mechanisms and diagnosis
title_fullStr	Leptin resistance: underlying mechanisms and diagnosis
title_full_unstemmed	Leptin resistance: underlying mechanisms and diagnosis
title_sort	leptin resistance: underlying mechanisms and diagnosis
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/25b9ea4fc8a84d80b1ed96fc5f1f6cde
work_keys_str_mv	AT gruzdevao leptinresistanceunderlyingmechanismsanddiagnosis AT borodkinad leptinresistanceunderlyingmechanismsanddiagnosis AT uchasovae leptinresistanceunderlyingmechanismsanddiagnosis AT dylevay leptinresistanceunderlyingmechanismsanddiagnosis AT barbarasho leptinresistanceunderlyingmechanismsanddiagnosis
_version_	1718402945774518272

Leptin resistance: underlying mechanisms and diagnosis

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