Structure of the cohesin loader Scc2

The cohesin complex maintains genome integrity by ensuring correct sister-chromatid segregation during mitosis and meiosis. Here, Chaoet al. present a pseudo-atomic model of the full-length Scc2–Scc4 cohesin loader complex and reveal key Scc2 surfaces crucial for cohesin loading.

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Autores principales:	William C. H. Chao, Yasuto Murayama, Sofía Muñoz, Andrew W. Jones, Benjamin O. Wade, Andrew G. Purkiss, Xiao-Wen Hu, Aaron Borg, Ambrosius P. Snijders, Frank Uhlmann, Martin R. Singleton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/25bc59bb4f5948bda1027f1901ef8ddf
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spelling	oai:doaj.org-article:25bc59bb4f5948bda1027f1901ef8ddf2021-12-02T14:40:57ZStructure of the cohesin loader Scc210.1038/ncomms139522041-1723https://doaj.org/article/25bc59bb4f5948bda1027f1901ef8ddf2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13952https://doaj.org/toc/2041-1723The cohesin complex maintains genome integrity by ensuring correct sister-chromatid segregation during mitosis and meiosis. Here, Chaoet al. present a pseudo-atomic model of the full-length Scc2–Scc4 cohesin loader complex and reveal key Scc2 surfaces crucial for cohesin loading.William C. H. ChaoYasuto MurayamaSofía MuñozAndrew W. JonesBenjamin O. WadeAndrew G. PurkissXiao-Wen HuAaron BorgAmbrosius P. SnijdersFrank UhlmannMartin R. SingletonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William C. H. Chao Yasuto Murayama Sofía Muñoz Andrew W. Jones Benjamin O. Wade Andrew G. Purkiss Xiao-Wen Hu Aaron Borg Ambrosius P. Snijders Frank Uhlmann Martin R. Singleton Structure of the cohesin loader Scc2
description	The cohesin complex maintains genome integrity by ensuring correct sister-chromatid segregation during mitosis and meiosis. Here, Chaoet al. present a pseudo-atomic model of the full-length Scc2–Scc4 cohesin loader complex and reveal key Scc2 surfaces crucial for cohesin loading.
format	article
author	William C. H. Chao Yasuto Murayama Sofía Muñoz Andrew W. Jones Benjamin O. Wade Andrew G. Purkiss Xiao-Wen Hu Aaron Borg Ambrosius P. Snijders Frank Uhlmann Martin R. Singleton
author_facet	William C. H. Chao Yasuto Murayama Sofía Muñoz Andrew W. Jones Benjamin O. Wade Andrew G. Purkiss Xiao-Wen Hu Aaron Borg Ambrosius P. Snijders Frank Uhlmann Martin R. Singleton
author_sort	William C. H. Chao
title	Structure of the cohesin loader Scc2
title_short	Structure of the cohesin loader Scc2
title_full	Structure of the cohesin loader Scc2
title_fullStr	Structure of the cohesin loader Scc2
title_full_unstemmed	Structure of the cohesin loader Scc2
title_sort	structure of the cohesin loader scc2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/25bc59bb4f5948bda1027f1901ef8ddf
work_keys_str_mv	AT williamchchao structureofthecohesinloaderscc2 AT yasutomurayama structureofthecohesinloaderscc2 AT sofiamunoz structureofthecohesinloaderscc2 AT andrewwjones structureofthecohesinloaderscc2 AT benjaminowade structureofthecohesinloaderscc2 AT andrewgpurkiss structureofthecohesinloaderscc2 AT xiaowenhu structureofthecohesinloaderscc2 AT aaronborg structureofthecohesinloaderscc2 AT ambrosiuspsnijders structureofthecohesinloaderscc2 AT frankuhlmann structureofthecohesinloaderscc2 AT martinrsingleton structureofthecohesinloaderscc2
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Structure of the cohesin loader Scc2

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