Comparative Efficacy and Safety of Anterograde vs. Retrograde Iodine Staining During Esophageal Chromoendoscopy: A Single-Center, Prospective, Parallel-Group, Randomized, Controlled, Single-Blind Trial

Background and Aim: Chromoendoscopy with iodine staining is an important diagnostic method for esophageal carcinomas or precancerous lesions. Unfortunately, iodine staining can be associated with numerous adverse events (AEs). We found that the starting position of spraying iodine solution is likely...

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Autores principales:	Xu Tian, Wei Yang, Wei-Qing Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	esophageal cancer endoscopic screening chromoendoscopy iodine solution staining Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/25bec56fc5344456832ea7b807bf3827
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spelling	oai:doaj.org-article:25bec56fc5344456832ea7b807bf38272021-11-30T23:35:58ZComparative Efficacy and Safety of Anterograde vs. Retrograde Iodine Staining During Esophageal Chromoendoscopy: A Single-Center, Prospective, Parallel-Group, Randomized, Controlled, Single-Blind Trial2296-858X10.3389/fmed.2021.764111https://doaj.org/article/25bec56fc5344456832ea7b807bf38272021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.764111/fullhttps://doaj.org/toc/2296-858XBackground and Aim: Chromoendoscopy with iodine staining is an important diagnostic method for esophageal carcinomas or precancerous lesions. Unfortunately, iodine staining can be associated with numerous adverse events (AEs). We found that the starting position of spraying iodine solution is likely the main reason of causing AEs. We conducted this work to determine whether clinical outcomes from anterograde iodine staining were superior to those achieved after retrograde iodine staining.Methods: A total of 134 subjects with a health risk appraisal flushing (HRA-F) score of >6 for esophageal cancer were randomly assigned to receive anterograde or retrograde iodine staining in the esophagus. The primary endpoints were the pain and the amount of iodine solution consumption. The secondary endpoints were iodine-staining effect, detection yield, and response to starch indicator.Results: Nine patients suffered from pain and six patients revealed positive response to starch indicator in retrograde iodine-staining group; however, no patient reported pain (0/67) and all patients revealed a negative response to starch indicator in anterograde iodine-staining group. The amount of iodine solution consumption in anterograde iodine-staining group (4.97 mL) was significantly lower than that (6.23 mL) in retrograde iodine-staining group; however, the iodine-staining effect and detection yield were comparable between the two groups.Conclusions: Anterograde iodine staining during Lugol chromoendoscopy appears to be as effective, but significantly safer than retrograde iodine staining.Xu TianWei YangWei-Qing ChenFrontiers Media S.A.articleesophageal cancerendoscopic screeningchromoendoscopyiodine solutionstainingMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	esophageal cancer endoscopic screening chromoendoscopy iodine solution staining Medicine (General) R5-920
spellingShingle	esophageal cancer endoscopic screening chromoendoscopy iodine solution staining Medicine (General) R5-920 Xu Tian Wei Yang Wei-Qing Chen Comparative Efficacy and Safety of Anterograde vs. Retrograde Iodine Staining During Esophageal Chromoendoscopy: A Single-Center, Prospective, Parallel-Group, Randomized, Controlled, Single-Blind Trial
description	Background and Aim: Chromoendoscopy with iodine staining is an important diagnostic method for esophageal carcinomas or precancerous lesions. Unfortunately, iodine staining can be associated with numerous adverse events (AEs). We found that the starting position of spraying iodine solution is likely the main reason of causing AEs. We conducted this work to determine whether clinical outcomes from anterograde iodine staining were superior to those achieved after retrograde iodine staining.Methods: A total of 134 subjects with a health risk appraisal flushing (HRA-F) score of >6 for esophageal cancer were randomly assigned to receive anterograde or retrograde iodine staining in the esophagus. The primary endpoints were the pain and the amount of iodine solution consumption. The secondary endpoints were iodine-staining effect, detection yield, and response to starch indicator.Results: Nine patients suffered from pain and six patients revealed positive response to starch indicator in retrograde iodine-staining group; however, no patient reported pain (0/67) and all patients revealed a negative response to starch indicator in anterograde iodine-staining group. The amount of iodine solution consumption in anterograde iodine-staining group (4.97 mL) was significantly lower than that (6.23 mL) in retrograde iodine-staining group; however, the iodine-staining effect and detection yield were comparable between the two groups.Conclusions: Anterograde iodine staining during Lugol chromoendoscopy appears to be as effective, but significantly safer than retrograde iodine staining.
format	article
author	Xu Tian Wei Yang Wei-Qing Chen
author_facet	Xu Tian Wei Yang Wei-Qing Chen
author_sort	Xu Tian
title	Comparative Efficacy and Safety of Anterograde vs. Retrograde Iodine Staining During Esophageal Chromoendoscopy: A Single-Center, Prospective, Parallel-Group, Randomized, Controlled, Single-Blind Trial
title_short	Comparative Efficacy and Safety of Anterograde vs. Retrograde Iodine Staining During Esophageal Chromoendoscopy: A Single-Center, Prospective, Parallel-Group, Randomized, Controlled, Single-Blind Trial
title_full	Comparative Efficacy and Safety of Anterograde vs. Retrograde Iodine Staining During Esophageal Chromoendoscopy: A Single-Center, Prospective, Parallel-Group, Randomized, Controlled, Single-Blind Trial
title_fullStr	Comparative Efficacy and Safety of Anterograde vs. Retrograde Iodine Staining During Esophageal Chromoendoscopy: A Single-Center, Prospective, Parallel-Group, Randomized, Controlled, Single-Blind Trial
title_full_unstemmed	Comparative Efficacy and Safety of Anterograde vs. Retrograde Iodine Staining During Esophageal Chromoendoscopy: A Single-Center, Prospective, Parallel-Group, Randomized, Controlled, Single-Blind Trial
title_sort	comparative efficacy and safety of anterograde vs. retrograde iodine staining during esophageal chromoendoscopy: a single-center, prospective, parallel-group, randomized, controlled, single-blind trial
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/25bec56fc5344456832ea7b807bf3827
work_keys_str_mv	AT xutian comparativeefficacyandsafetyofanterogradevsretrogradeiodinestainingduringesophagealchromoendoscopyasinglecenterprospectiveparallelgrouprandomizedcontrolledsingleblindtrial AT weiyang comparativeefficacyandsafetyofanterogradevsretrogradeiodinestainingduringesophagealchromoendoscopyasinglecenterprospectiveparallelgrouprandomizedcontrolledsingleblindtrial AT weiqingchen comparativeefficacyandsafetyofanterogradevsretrogradeiodinestainingduringesophagealchromoendoscopyasinglecenterprospectiveparallelgrouprandomizedcontrolledsingleblindtrial
_version_	1718406189891452928

Comparative Efficacy and Safety of Anterograde vs. Retrograde Iodine Staining During Esophageal Chromoendoscopy: A Single-Center, Prospective, Parallel-Group, Randomized, Controlled, Single-Blind Trial

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