Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response

During an immune response, CD4+ T cell repertoire is thought to increase in avidity at the expense of diversity. Here the authors show that B cells act as antigen-presenting cells to boost the development of low-avidity T cell clones, diversifying the T cell repertoire at late stages of the response...

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Autores principales:	Julia Merkenschlager, Mickaël J. Ploquin, Urszula Eksmond, Rakieb Andargachew, Georgina Thorborn, Andrew Filby, Marion Pepper, Brian Evavold, George Kassiotis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/25bffa91449947648b99e2c787621c0f
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spelling	oai:doaj.org-article:25bffa91449947648b99e2c787621c0f2021-12-02T14:39:14ZStepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response10.1038/ncomms102812041-1723https://doaj.org/article/25bffa91449947648b99e2c787621c0f2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10281https://doaj.org/toc/2041-1723During an immune response, CD4+ T cell repertoire is thought to increase in avidity at the expense of diversity. Here the authors show that B cells act as antigen-presenting cells to boost the development of low-avidity T cell clones, diversifying the T cell repertoire at late stages of the response.Julia MerkenschlagerMickaël J. PloquinUrszula EksmondRakieb AndargachewGeorgina ThorbornAndrew FilbyMarion PepperBrian EvavoldGeorge KassiotisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julia Merkenschlager Mickaël J. Ploquin Urszula Eksmond Rakieb Andargachew Georgina Thorborn Andrew Filby Marion Pepper Brian Evavold George Kassiotis Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response
description	During an immune response, CD4+ T cell repertoire is thought to increase in avidity at the expense of diversity. Here the authors show that B cells act as antigen-presenting cells to boost the development of low-avidity T cell clones, diversifying the T cell repertoire at late stages of the response.
format	article
author	Julia Merkenschlager Mickaël J. Ploquin Urszula Eksmond Rakieb Andargachew Georgina Thorborn Andrew Filby Marion Pepper Brian Evavold George Kassiotis
author_facet	Julia Merkenschlager Mickaël J. Ploquin Urszula Eksmond Rakieb Andargachew Georgina Thorborn Andrew Filby Marion Pepper Brian Evavold George Kassiotis
author_sort	Julia Merkenschlager
title	Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response
title_short	Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response
title_full	Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response
title_fullStr	Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response
title_full_unstemmed	Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response
title_sort	stepwise b-cell-dependent expansion of t helper clonotypes diversifies the t-cell response
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/25bffa91449947648b99e2c787621c0f
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Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response

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