CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

Emerging SARS-CoV-2 variants with mutations in the spike protein raise concerns regarding vaccine efficacy. Here, the authors show that two spike encoding mRNA vaccines in preclinical and clinical development protect human ACE2 mice from the B.1.351 variant of concern and ancestral B BavPat1.

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Autores principales: Donata Hoffmann, Björn Corleis, Susanne Rauch, Nicole Roth, Janine Mühe, Nico Joel Halwe, Lorenz Ulrich, Charlie Fricke, Jacob Schön, Anna Kraft, Angele Breithaupt, Kerstin Wernike, Anna Michelitsch, Franziska Sick, Claudia Wylezich, Bernd Hoffmann, Moritz Thran, Andreas Thess, Stefan O. Mueller, Thomas C. Mettenleiter, Benjamin Petsch, Anca Dorhoi, Martin Beer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/25c1d158976849108a4f7763b4e1755a
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spelling oai:doaj.org-article:25c1d158976849108a4f7763b4e1755a2021-12-02T16:10:51ZCVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-210.1038/s41467-021-24339-72041-1723https://doaj.org/article/25c1d158976849108a4f7763b4e1755a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24339-7https://doaj.org/toc/2041-1723Emerging SARS-CoV-2 variants with mutations in the spike protein raise concerns regarding vaccine efficacy. Here, the authors show that two spike encoding mRNA vaccines in preclinical and clinical development protect human ACE2 mice from the B.1.351 variant of concern and ancestral B BavPat1.Donata HoffmannBjörn CorleisSusanne RauchNicole RothJanine MüheNico Joel HalweLorenz UlrichCharlie FrickeJacob SchönAnna KraftAngele BreithauptKerstin WernikeAnna MichelitschFranziska SickClaudia WylezichBernd HoffmannMoritz ThranAndreas ThessStefan O. MuellerThomas C. MettenleiterBenjamin PetschAnca DorhoiMartin BeerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Donata Hoffmann
Björn Corleis
Susanne Rauch
Nicole Roth
Janine Mühe
Nico Joel Halwe
Lorenz Ulrich
Charlie Fricke
Jacob Schön
Anna Kraft
Angele Breithaupt
Kerstin Wernike
Anna Michelitsch
Franziska Sick
Claudia Wylezich
Bernd Hoffmann
Moritz Thran
Andreas Thess
Stefan O. Mueller
Thomas C. Mettenleiter
Benjamin Petsch
Anca Dorhoi
Martin Beer
CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2
description Emerging SARS-CoV-2 variants with mutations in the spike protein raise concerns regarding vaccine efficacy. Here, the authors show that two spike encoding mRNA vaccines in preclinical and clinical development protect human ACE2 mice from the B.1.351 variant of concern and ancestral B BavPat1.
format article
author Donata Hoffmann
Björn Corleis
Susanne Rauch
Nicole Roth
Janine Mühe
Nico Joel Halwe
Lorenz Ulrich
Charlie Fricke
Jacob Schön
Anna Kraft
Angele Breithaupt
Kerstin Wernike
Anna Michelitsch
Franziska Sick
Claudia Wylezich
Bernd Hoffmann
Moritz Thran
Andreas Thess
Stefan O. Mueller
Thomas C. Mettenleiter
Benjamin Petsch
Anca Dorhoi
Martin Beer
author_facet Donata Hoffmann
Björn Corleis
Susanne Rauch
Nicole Roth
Janine Mühe
Nico Joel Halwe
Lorenz Ulrich
Charlie Fricke
Jacob Schön
Anna Kraft
Angele Breithaupt
Kerstin Wernike
Anna Michelitsch
Franziska Sick
Claudia Wylezich
Bernd Hoffmann
Moritz Thran
Andreas Thess
Stefan O. Mueller
Thomas C. Mettenleiter
Benjamin Petsch
Anca Dorhoi
Martin Beer
author_sort Donata Hoffmann
title CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2
title_short CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2
title_full CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2
title_fullStr CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2
title_full_unstemmed CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2
title_sort cvncov and cv2cov protect human ace2 transgenic mice from ancestral b bavpat1 and emerging b.1.351 sars-cov-2
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/25c1d158976849108a4f7763b4e1755a
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