Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans

Here, Khurana et al. report the results of a phase 4 clinical trial with three FDA approved influenza vaccines and show that repeat influenza vaccination results in reduced antibody affinity maturation to hemagglutinin domain 1 irrespective of vaccine platform.

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Autores principales: Surender Khurana, Megan Hahn, Elizabeth M. Coyle, Lisa R. King, Tsai-Lien Lin, John Treanor, Andrea Sant, Hana Golding
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/25c5be5b8b3340e9bfab6fabc559795c
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Sumario:Here, Khurana et al. report the results of a phase 4 clinical trial with three FDA approved influenza vaccines and show that repeat influenza vaccination results in reduced antibody affinity maturation to hemagglutinin domain 1 irrespective of vaccine platform.