Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans

Here, Khurana et al. report the results of a phase 4 clinical trial with three FDA approved influenza vaccines and show that repeat influenza vaccination results in reduced antibody affinity maturation to hemagglutinin domain 1 irrespective of vaccine platform.

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Autores principales:	Surender Khurana, Megan Hahn, Elizabeth M. Coyle, Lisa R. King, Tsai-Lien Lin, John Treanor, Andrea Sant, Hana Golding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/25c5be5b8b3340e9bfab6fabc559795c
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spelling	oai:doaj.org-article:25c5be5b8b3340e9bfab6fabc559795c2021-12-02T16:57:22ZRepeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans10.1038/s41467-019-11296-52041-1723https://doaj.org/article/25c5be5b8b3340e9bfab6fabc559795c2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11296-5https://doaj.org/toc/2041-1723Here, Khurana et al. report the results of a phase 4 clinical trial with three FDA approved influenza vaccines and show that repeat influenza vaccination results in reduced antibody affinity maturation to hemagglutinin domain 1 irrespective of vaccine platform.Surender KhuranaMegan HahnElizabeth M. CoyleLisa R. KingTsai-Lien LinJohn TreanorAndrea SantHana GoldingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Surender Khurana Megan Hahn Elizabeth M. Coyle Lisa R. King Tsai-Lien Lin John Treanor Andrea Sant Hana Golding Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
description	Here, Khurana et al. report the results of a phase 4 clinical trial with three FDA approved influenza vaccines and show that repeat influenza vaccination results in reduced antibody affinity maturation to hemagglutinin domain 1 irrespective of vaccine platform.
format	article
author	Surender Khurana Megan Hahn Elizabeth M. Coyle Lisa R. King Tsai-Lien Lin John Treanor Andrea Sant Hana Golding
author_facet	Surender Khurana Megan Hahn Elizabeth M. Coyle Lisa R. King Tsai-Lien Lin John Treanor Andrea Sant Hana Golding
author_sort	Surender Khurana
title	Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
title_short	Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
title_full	Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
title_fullStr	Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
title_full_unstemmed	Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
title_sort	repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/25c5be5b8b3340e9bfab6fabc559795c
work_keys_str_mv	AT surenderkhurana repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT meganhahn repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT elizabethmcoyle repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT lisarking repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT tsailienlin repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT johntreanor repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT andreasant repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT hanagolding repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans
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Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans

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