Severe agitation in severe early-onset Alzheimer’s disease resolves with ECT

Severe agitation in severe early-onset Alzheimer’s disease resolves with ECT

Suna Su Aksay, Lucrezia Hausner, Lutz Frölich, Alexander Sartorius Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany Abstract: Dementia-related behavioral disturbances are mostly treated with...

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Autores principales: Aksay SS, Hausner L, Frölich L, Sartorius A
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/25c60030a5944ed8890096cc75f69b9f
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spelling oai:doaj.org-article:25c60030a5944ed8890096cc75f69b9f2021-12-02T06:50:34ZSevere agitation in severe early-onset Alzheimer’s disease resolves with ECT1178-2021https://doaj.org/article/25c60030a5944ed8890096cc75f69b9f2014-11-01T00:00:00Zhttp://www.dovepress.com/severe-agitation-in-severe-early-onset-alzheimerrsquosnbspdisease-reso-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Suna Su Aksay, Lucrezia Hausner, Lutz Frölich, Alexander Sartorius Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany Abstract: Dementia-related behavioral disturbances are mostly treated with antipsychotics; however, the observed beneficial effects are modest and the risk of serious adverse effects high. We report the case of a 57-year-old woman with severe early-onset Alzheimer’s disease and severe agitation, whom we treated with electroconvulsive therapy (ECT). A significant clinical improvement was achieved over eight ECT sessions, which were tolerated well without cognitive worsening, and lasted approximately 3 months. Our case demonstrates the safe and effective use of ECT in pharmacotherapy-resistant severe agitation in Alzheimer’s disease. The risk–benefit profile of ECT for dementia-related agitation should be further investigated in clinical trials. Keywords: dementia, electroconvulsive therapy, cognition, emotional distress, disinhibition.Aksay SSHausner LFrölich LSartorius ADove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 2147-2151 (2014)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Aksay SS
Hausner L
Frölich L
Sartorius A
Severe agitation in severe early-onset Alzheimer’s disease resolves with ECT
description Suna Su Aksay, Lucrezia Hausner, Lutz Frölich, Alexander Sartorius Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany Abstract: Dementia-related behavioral disturbances are mostly treated with antipsychotics; however, the observed beneficial effects are modest and the risk of serious adverse effects high. We report the case of a 57-year-old woman with severe early-onset Alzheimer’s disease and severe agitation, whom we treated with electroconvulsive therapy (ECT). A significant clinical improvement was achieved over eight ECT sessions, which were tolerated well without cognitive worsening, and lasted approximately 3 months. Our case demonstrates the safe and effective use of ECT in pharmacotherapy-resistant severe agitation in Alzheimer’s disease. The risk–benefit profile of ECT for dementia-related agitation should be further investigated in clinical trials. Keywords: dementia, electroconvulsive therapy, cognition, emotional distress, disinhibition.
format article
author Aksay SS
Hausner L
Frölich L
Sartorius A
author_facet Aksay SS
Hausner L
Frölich L
Sartorius A
author_sort Aksay SS
title Severe agitation in severe early-onset Alzheimer’s disease resolves with ECT
title_short Severe agitation in severe early-onset Alzheimer’s disease resolves with ECT
title_full Severe agitation in severe early-onset Alzheimer’s disease resolves with ECT
title_fullStr Severe agitation in severe early-onset Alzheimer’s disease resolves with ECT
title_full_unstemmed Severe agitation in severe early-onset Alzheimer’s disease resolves with ECT
title_sort severe agitation in severe early-onset alzheimer’s disease resolves with ect
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/25c60030a5944ed8890096cc75f69b9f
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AT hausnerl severeagitationinsevereearlyonsetalzheimerrsquosnbspdiseaseresolveswithect
AT frolichl severeagitationinsevereearlyonsetalzheimerrsquosnbspdiseaseresolveswithect
AT sartoriusa severeagitationinsevereearlyonsetalzheimerrsquosnbspdiseaseresolveswithect
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