Patterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.

Oscillatory and sequential processes have been implicated in the spatial patterning of many embryonic tissues. For example, molecular clocks delimit segmental boundaries in vertebrates and insects and mediate lateral root formation in plants, whereas sequential gene activities are involved in the sp...

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Autores principales:	Margarete Diaz-Cuadros, Olivier Pourquié, Ezzat El-Sherif
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/25c6d5c1e8f94c68adc64418e5bb9350
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spelling	oai:doaj.org-article:25c6d5c1e8f94c68adc64418e5bb93502021-12-02T20:03:31ZPatterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.1553-73901553-740410.1371/journal.pgen.1009812https://doaj.org/article/25c6d5c1e8f94c68adc64418e5bb93502021-10-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009812https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404Oscillatory and sequential processes have been implicated in the spatial patterning of many embryonic tissues. For example, molecular clocks delimit segmental boundaries in vertebrates and insects and mediate lateral root formation in plants, whereas sequential gene activities are involved in the specification of regional identities of insect neuroblasts, vertebrate neural tube, vertebrate limb, and insect and vertebrate body axes. These processes take place in various tissues and organisms, and, hence, raise the question of what common themes and strategies they share. In this article, we review 2 processes that rely on the spatial regulation of periodic and sequential gene activities: segmentation and regionalization of the anterior-posterior (AP) axis of animal body plans. We study these processes in species that belong to 2 different phyla: vertebrates and insects. By contrasting 2 different processes (segmentation and regionalization) in species that belong to 2 distantly related phyla (arthropods and vertebrates), we elucidate the deep logic of patterning by oscillatory and sequential gene activities. Furthermore, in some of these organisms (e.g., the fruit fly Drosophila), a mode of AP patterning has evolved that seems not to overtly rely on oscillations or sequential gene activities, providing an opportunity to study the evolution of pattern formation mechanisms.Margarete Diaz-CuadrosOlivier PourquiéEzzat El-SherifPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 10, p e1009812 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Margarete Diaz-Cuadros Olivier Pourquié Ezzat El-Sherif Patterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.
description	Oscillatory and sequential processes have been implicated in the spatial patterning of many embryonic tissues. For example, molecular clocks delimit segmental boundaries in vertebrates and insects and mediate lateral root formation in plants, whereas sequential gene activities are involved in the specification of regional identities of insect neuroblasts, vertebrate neural tube, vertebrate limb, and insect and vertebrate body axes. These processes take place in various tissues and organisms, and, hence, raise the question of what common themes and strategies they share. In this article, we review 2 processes that rely on the spatial regulation of periodic and sequential gene activities: segmentation and regionalization of the anterior-posterior (AP) axis of animal body plans. We study these processes in species that belong to 2 different phyla: vertebrates and insects. By contrasting 2 different processes (segmentation and regionalization) in species that belong to 2 distantly related phyla (arthropods and vertebrates), we elucidate the deep logic of patterning by oscillatory and sequential gene activities. Furthermore, in some of these organisms (e.g., the fruit fly Drosophila), a mode of AP patterning has evolved that seems not to overtly rely on oscillations or sequential gene activities, providing an opportunity to study the evolution of pattern formation mechanisms.
format	article
author	Margarete Diaz-Cuadros Olivier Pourquié Ezzat El-Sherif
author_facet	Margarete Diaz-Cuadros Olivier Pourquié Ezzat El-Sherif
author_sort	Margarete Diaz-Cuadros
title	Patterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.
title_short	Patterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.
title_full	Patterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.
title_fullStr	Patterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.
title_full_unstemmed	Patterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.
title_sort	patterning with clocks and genetic cascades: segmentation and regionalization of vertebrate versus insect body plans.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/25c6d5c1e8f94c68adc64418e5bb9350
work_keys_str_mv	AT margaretediazcuadros patterningwithclocksandgeneticcascadessegmentationandregionalizationofvertebrateversusinsectbodyplans AT olivierpourquie patterningwithclocksandgeneticcascadessegmentationandregionalizationofvertebrateversusinsectbodyplans AT ezzatelsherif patterningwithclocksandgeneticcascadessegmentationandregionalizationofvertebrateversusinsectbodyplans
_version_	1718375648128401408

Patterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.

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