Metabolic Reprogramming in COVID-19

Plenty of research has revealed virus induced alternations in metabolic pathways, which is known as metabolic reprogramming. Studies focusing on COVID-19 have uncovered significant changes in metabolism, resulting in the perspective that COVID-19 is a metabolic disease. Reprogramming of amino acid,...

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Autores principales:	Tao Shen, Tingting Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 metabolic changes tryptophan arginine glucose cholesterol Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/25cae6c320ed4e2199cfe038de9c0165
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id	oai:doaj.org-article:25cae6c320ed4e2199cfe038de9c0165
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spelling	oai:doaj.org-article:25cae6c320ed4e2199cfe038de9c01652021-11-11T16:56:28ZMetabolic Reprogramming in COVID-1910.3390/ijms2221114751422-00671661-6596https://doaj.org/article/25cae6c320ed4e2199cfe038de9c01652021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11475https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Plenty of research has revealed virus induced alternations in metabolic pathways, which is known as metabolic reprogramming. Studies focusing on COVID-19 have uncovered significant changes in metabolism, resulting in the perspective that COVID-19 is a metabolic disease. Reprogramming of amino acid, glucose, cholesterol and fatty acid is distinctive characteristic of COVID-19 infection. These metabolic changes in COVID-19 have a critical role not only in producing energy and virus constituent elements, but also in regulating immune response, offering new insights into COVID-19 pathophysiology. Remarkably, metabolic reprogramming provides great opportunities for developing novel biomarkers and therapeutic agents for COVID-19 infection. Such novel agents are expected to be effective adjuvant therapies. In this review, we integrate present studies about major metabolic reprogramming in COVID-19, as well as the possibility of targeting reprogrammed metabolism to combat virus infection.Tao ShenTingting WangMDPI AGarticleCOVID-19metabolic changestryptophanarginineglucosecholesterolBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11475, p 11475 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 metabolic changes tryptophan arginine glucose cholesterol Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	COVID-19 metabolic changes tryptophan arginine glucose cholesterol Biology (General) QH301-705.5 Chemistry QD1-999 Tao Shen Tingting Wang Metabolic Reprogramming in COVID-19
description	Plenty of research has revealed virus induced alternations in metabolic pathways, which is known as metabolic reprogramming. Studies focusing on COVID-19 have uncovered significant changes in metabolism, resulting in the perspective that COVID-19 is a metabolic disease. Reprogramming of amino acid, glucose, cholesterol and fatty acid is distinctive characteristic of COVID-19 infection. These metabolic changes in COVID-19 have a critical role not only in producing energy and virus constituent elements, but also in regulating immune response, offering new insights into COVID-19 pathophysiology. Remarkably, metabolic reprogramming provides great opportunities for developing novel biomarkers and therapeutic agents for COVID-19 infection. Such novel agents are expected to be effective adjuvant therapies. In this review, we integrate present studies about major metabolic reprogramming in COVID-19, as well as the possibility of targeting reprogrammed metabolism to combat virus infection.
format	article
author	Tao Shen Tingting Wang
author_facet	Tao Shen Tingting Wang
author_sort	Tao Shen
title	Metabolic Reprogramming in COVID-19
title_short	Metabolic Reprogramming in COVID-19
title_full	Metabolic Reprogramming in COVID-19
title_fullStr	Metabolic Reprogramming in COVID-19
title_full_unstemmed	Metabolic Reprogramming in COVID-19
title_sort	metabolic reprogramming in covid-19
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/25cae6c320ed4e2199cfe038de9c0165
work_keys_str_mv	AT taoshen metabolicreprogrammingincovid19 AT tingtingwang metabolicreprogrammingincovid19
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Metabolic Reprogramming in COVID-19

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