A PATHOGENETIC ROLE OF TRANSCRIPTION COREPRESSOR Id2 IN BRONCHIAL ASTHMA

The aim of present study was to evaluate a possible role of Id2 (inhibitor of DNA-binding 2) in pathogenesis of bronchial asthma (BA). We have examined six healthy control persons, nine patients with allergic bronchial asthma (ABA) and twenty-four patients with non-allergic bronchial asthma (NABA)....

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Autores principales:	V. N. Mineev, M. A. Nyoma, L. N. Sorokina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	bronchial asthma id2 transcription immunoglobulin е lymphocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/25cb610f7aac4ff89bd4ec9fa9cd82a9
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spelling	oai:doaj.org-article:25cb610f7aac4ff89bd4ec9fa9cd82a92021-11-18T08:03:45ZA PATHOGENETIC ROLE OF TRANSCRIPTION COREPRESSOR Id2 IN BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2016-2-183-186https://doaj.org/article/25cb610f7aac4ff89bd4ec9fa9cd82a92016-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1002https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of present study was to evaluate a possible role of Id2 (inhibitor of DNA-binding 2) in pathogenesis of bronchial asthma (BA). We have examined six healthy control persons, nine patients with allergic bronchial asthma (ABA) and twenty-four patients with non-allergic bronchial asthma (NABA). The Id2 mRNA expression was evaluated by means of real-time PCR.No significant differences in Id2 mRNA expression levels were revealed between the control and asthma groups. Correlation analysis of Id2 mRNA expression has revealed significant positive correlation with AID (activation-induced cytidine deaminase) mRNA levels and peripheric blood eosinophil contents in ABA. Healthy persons demonstrate strong positive correlation between Id2 mRNA expression and serum IgE levels, like as with ε-chain mRNA contents.It was suggested that the Id2 dysfunction may take place in the BA patients. These changes affect negative control over the AID expression, which is important for switching B-cells to IgE production.V. N. MineevM. A. NyomaL. N. SorokinaSPb RAACIarticlebronchial asthmaid2transcriptionimmunoglobulin еlymphocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 2, Pp 183-186 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	bronchial asthma id2 transcription immunoglobulin е lymphocytes Immunologic diseases. Allergy RC581-607
spellingShingle	bronchial asthma id2 transcription immunoglobulin е lymphocytes Immunologic diseases. Allergy RC581-607 V. N. Mineev M. A. Nyoma L. N. Sorokina A PATHOGENETIC ROLE OF TRANSCRIPTION COREPRESSOR Id2 IN BRONCHIAL ASTHMA
description	The aim of present study was to evaluate a possible role of Id2 (inhibitor of DNA-binding 2) in pathogenesis of bronchial asthma (BA). We have examined six healthy control persons, nine patients with allergic bronchial asthma (ABA) and twenty-four patients with non-allergic bronchial asthma (NABA). The Id2 mRNA expression was evaluated by means of real-time PCR.No significant differences in Id2 mRNA expression levels were revealed between the control and asthma groups. Correlation analysis of Id2 mRNA expression has revealed significant positive correlation with AID (activation-induced cytidine deaminase) mRNA levels and peripheric blood eosinophil contents in ABA. Healthy persons demonstrate strong positive correlation between Id2 mRNA expression and serum IgE levels, like as with ε-chain mRNA contents.It was suggested that the Id2 dysfunction may take place in the BA patients. These changes affect negative control over the AID expression, which is important for switching B-cells to IgE production.
format	article
author	V. N. Mineev M. A. Nyoma L. N. Sorokina
author_facet	V. N. Mineev M. A. Nyoma L. N. Sorokina
author_sort	V. N. Mineev
title	A PATHOGENETIC ROLE OF TRANSCRIPTION COREPRESSOR Id2 IN BRONCHIAL ASTHMA
title_short	A PATHOGENETIC ROLE OF TRANSCRIPTION COREPRESSOR Id2 IN BRONCHIAL ASTHMA
title_full	A PATHOGENETIC ROLE OF TRANSCRIPTION COREPRESSOR Id2 IN BRONCHIAL ASTHMA
title_fullStr	A PATHOGENETIC ROLE OF TRANSCRIPTION COREPRESSOR Id2 IN BRONCHIAL ASTHMA
title_full_unstemmed	A PATHOGENETIC ROLE OF TRANSCRIPTION COREPRESSOR Id2 IN BRONCHIAL ASTHMA
title_sort	pathogenetic role of transcription corepressor id2 in bronchial asthma
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/25cb610f7aac4ff89bd4ec9fa9cd82a9
work_keys_str_mv	AT vnmineev apathogeneticroleoftranscriptioncorepressorid2inbronchialasthma AT manyoma apathogeneticroleoftranscriptioncorepressorid2inbronchialasthma AT lnsorokina apathogeneticroleoftranscriptioncorepressorid2inbronchialasthma AT vnmineev pathogeneticroleoftranscriptioncorepressorid2inbronchialasthma AT manyoma pathogeneticroleoftranscriptioncorepressorid2inbronchialasthma AT lnsorokina pathogeneticroleoftranscriptioncorepressorid2inbronchialasthma
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A PATHOGENETIC ROLE OF TRANSCRIPTION COREPRESSOR Id2 IN BRONCHIAL ASTHMA

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