Role of plasminogen activator inhibitor and free fatty acids in diagnosis of insulin resistance in patients with myocardial infarction
Aim. Evaluation of the dynamics of the markers of insulin resistance in patients with myocardial infarction with ST-segment elevation with andwithout type 2 diabetes mellitus in the acute and early recovery period of the disease. Materials and methods. The study included 95 patients with myocardia...
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Endocrinology Research Centre
2011
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oai:doaj.org-article:25ccf6dd8f0e4476ad44bb65b92a93e32021-11-14T09:00:16ZRole of plasminogen activator inhibitor and free fatty acids in diagnosis of insulin resistance in patients with myocardial infarction2072-03512072-037810.14341/2072-0351-5811https://doaj.org/article/25ccf6dd8f0e4476ad44bb65b92a93e32011-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5811https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. Evaluation of the dynamics of the markers of insulin resistance in patients with myocardial infarction with ST-segment elevation with andwithout type 2 diabetes mellitus in the acute and early recovery period of the disease. Materials and methods. The study included 95 patients with myocardial infarction and 60 patients with myocardial infarction and type 2 diabetes.The control group consisted of 30 persons. We all studied at 1 st and 12 th day of myocardial infarction was determined by the content of free fattyacids, glucose, C-peptide, insulin in serum and plasminogen activator inhibitor in blood plasma. In addition, the 12 th day was determined postprandialglycemic, insulin and C-peptide 2h after a standard carbohydrate breakfast. Results. It is established that during myocardial infarction accompanied by the development of insulin resistance, characterized by postprandialglycemia and insulinemia, as well as the presence of elevated levels of free fatty acids, plasminogen activator inhibitor. Conclusion. The definition of metabolic markers of insulin resistance may be of great predictive capacity for assessing the risk of both acute coronaryevents and select tactics to further treatmentOlga Viktorovna GruzdevaOlga Leonidovna BarbarashOlga Evgen'evna AkbashevaTatiana Sergeevna FedorovaElena Ivanovna PalichevaVasil'evich KashtalapYulia Alexandrovna DylevaAnna Alexandrovna SilonovaEkaterina Vladimirovna SioninaEvgenia Gennad'evna UchasovaEndocrinology Research Centrearticletype 2 diabetes mellitusmyocardial infarctioninsulin resistancefree fatty acidsplasminogen activator inhibitor type-1Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 4, Pp 18-23 (2011) |
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EN RU |
| topic |
type 2 diabetes mellitus myocardial infarction insulin resistance free fatty acids plasminogen activator inhibitor type-1 Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
type 2 diabetes mellitus myocardial infarction insulin resistance free fatty acids plasminogen activator inhibitor type-1 Nutritional diseases. Deficiency diseases RC620-627 Olga Viktorovna Gruzdeva Olga Leonidovna Barbarash Olga Evgen'evna Akbasheva Tatiana Sergeevna Fedorova Elena Ivanovna Palicheva Vasil'evich Kashtalap Yulia Alexandrovna Dyleva Anna Alexandrovna Silonova Ekaterina Vladimirovna Sionina Evgenia Gennad'evna Uchasova Role of plasminogen activator inhibitor and free fatty acids in diagnosis of insulin resistance in patients with myocardial infarction |
| description |
Aim. Evaluation of the dynamics of the markers of insulin resistance in patients with myocardial infarction with ST-segment elevation with andwithout type 2 diabetes mellitus in the acute and early recovery period of the disease. Materials and methods. The study included 95 patients with myocardial infarction and 60 patients with myocardial infarction and type 2 diabetes.The control group consisted of 30 persons. We all studied at 1 st and 12 th day of myocardial infarction was determined by the content of free fattyacids, glucose, C-peptide, insulin in serum and plasminogen activator inhibitor in blood plasma. In addition, the 12 th day was determined postprandialglycemic, insulin and C-peptide 2h after a standard carbohydrate breakfast. Results. It is established that during myocardial infarction accompanied by the development of insulin resistance, characterized by postprandialglycemia and insulinemia, as well as the presence of elevated levels of free fatty acids, plasminogen activator inhibitor. Conclusion. The definition of metabolic markers of insulin resistance may be of great predictive capacity for assessing the risk of both acute coronaryevents and select tactics to further treatment |
| format |
article |
| author |
Olga Viktorovna Gruzdeva Olga Leonidovna Barbarash Olga Evgen'evna Akbasheva Tatiana Sergeevna Fedorova Elena Ivanovna Palicheva Vasil'evich Kashtalap Yulia Alexandrovna Dyleva Anna Alexandrovna Silonova Ekaterina Vladimirovna Sionina Evgenia Gennad'evna Uchasova |
| author_facet |
Olga Viktorovna Gruzdeva Olga Leonidovna Barbarash Olga Evgen'evna Akbasheva Tatiana Sergeevna Fedorova Elena Ivanovna Palicheva Vasil'evich Kashtalap Yulia Alexandrovna Dyleva Anna Alexandrovna Silonova Ekaterina Vladimirovna Sionina Evgenia Gennad'evna Uchasova |
| author_sort |
Olga Viktorovna Gruzdeva |
| title |
Role of plasminogen activator inhibitor and free fatty acids in diagnosis of insulin resistance in patients with myocardial infarction |
| title_short |
Role of plasminogen activator inhibitor and free fatty acids in diagnosis of insulin resistance in patients with myocardial infarction |
| title_full |
Role of plasminogen activator inhibitor and free fatty acids in diagnosis of insulin resistance in patients with myocardial infarction |
| title_fullStr |
Role of plasminogen activator inhibitor and free fatty acids in diagnosis of insulin resistance in patients with myocardial infarction |
| title_full_unstemmed |
Role of plasminogen activator inhibitor and free fatty acids in diagnosis of insulin resistance in patients with myocardial infarction |
| title_sort |
role of plasminogen activator inhibitor and free fatty acids in diagnosis of insulin resistance in patients with myocardial infarction |
| publisher |
Endocrinology Research Centre |
| publishDate |
2011 |
| url |
https://doaj.org/article/25ccf6dd8f0e4476ad44bb65b92a93e3 |
| work_keys_str_mv |
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