Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols

Controllable deuteration of N-alkyl amines is crucial in drug-development as they constitute over 50% of the top-selling drugs. Here, the authors report a polymeric semiconductor acting as photocatalyst in water-splitting and in isotope alkanol-oxidation by photoexcited electron-hole pairs, and furn...

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Autores principales:	Zhaofei Zhang, Chuntian Qiu, Yangsen Xu, Qing Han, Junwang Tang, Kian Ping Loh, Chenliang Su
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/25ce76b9ead54c09be5c8a90ae0e434e
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spelling	oai:doaj.org-article:25ce76b9ead54c09be5c8a90ae0e434e2021-12-02T18:02:08ZSemiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols10.1038/s41467-020-18458-w2041-1723https://doaj.org/article/25ce76b9ead54c09be5c8a90ae0e434e2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18458-whttps://doaj.org/toc/2041-1723Controllable deuteration of N-alkyl amines is crucial in drug-development as they constitute over 50% of the top-selling drugs. Here, the authors report a polymeric semiconductor acting as photocatalyst in water-splitting and in isotope alkanol-oxidation by photoexcited electron-hole pairs, and furnishing deuterated amines.Zhaofei ZhangChuntian QiuYangsen XuQing HanJunwang TangKian Ping LohChenliang SuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhaofei Zhang Chuntian Qiu Yangsen Xu Qing Han Junwang Tang Kian Ping Loh Chenliang Su Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols
description	Controllable deuteration of N-alkyl amines is crucial in drug-development as they constitute over 50% of the top-selling drugs. Here, the authors report a polymeric semiconductor acting as photocatalyst in water-splitting and in isotope alkanol-oxidation by photoexcited electron-hole pairs, and furnishing deuterated amines.
format	article
author	Zhaofei Zhang Chuntian Qiu Yangsen Xu Qing Han Junwang Tang Kian Ping Loh Chenliang Su
author_facet	Zhaofei Zhang Chuntian Qiu Yangsen Xu Qing Han Junwang Tang Kian Ping Loh Chenliang Su
author_sort	Zhaofei Zhang
title	Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols
title_short	Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols
title_full	Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols
title_fullStr	Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols
title_full_unstemmed	Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols
title_sort	semiconductor photocatalysis to engineering deuterated n-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/25ce76b9ead54c09be5c8a90ae0e434e
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_version_	1718378915949445120

Semiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols

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