Estimating the population at high risk for tuberculosis through household exposure in high-incidence countries: a model-based analysis
Background: Household contacts of people with pulmonary tuberculosis (TB) have greater risk of developing TB. Recent guidelines conditionally recommended TB preventive treatment (TPT) for household contacts of any age living in TB high-incidence countries, expanding earlier guidance to provide TPT t...
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2021
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oai:doaj.org-article:25d1cc1484a14152a547fbc809a5e30a2021-11-24T04:33:18ZEstimating the population at high risk for tuberculosis through household exposure in high-incidence countries: a model-based analysis2589-537010.1016/j.eclinm.2021.101206https://doaj.org/article/25d1cc1484a14152a547fbc809a5e30a2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589537021004879https://doaj.org/toc/2589-5370Background: Household contacts of people with pulmonary tuberculosis (TB) have greater risk of developing TB. Recent guidelines conditionally recommended TB preventive treatment (TPT) for household contacts of any age living in TB high-incidence countries, expanding earlier guidance to provide TPT to household contacts under five. The all-age population of household contacts has not been estimated. Methods: Our model-based estimation included 20 countries with >80% of incident TB globally in 2019. We developed country-specific distributions of household composition by age and sex using bootstrap resampling from health surveys and census data. We incorporated age-, sex-, year-, and location-specific estimates of pulmonary TB incidence from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 to estimate the population in each country sharing a household with someone with incident pulmonary TB, and quantified uncertainty using a Monte Carlo approach. Findings: We estimate that 38 million [95% uncertainty interval (UI) 33- 43 million] individuals lived in a household with someone with incident pulmonary TB in 2019 in these 20 countries. Children under five made up 12% of the population with household exposure, while adults were 65%. Zimbabwe, Mozambique, Zambia, and Pakistan had the highest proportion of the population with household exposure, while India had the highest number of contacts (11·4 million, 95% UI 9·7-13·4 million). Interpretation: Expanding TPT evaluation to household contacts of all ages in high-incidence countries could include a population more than 7-times larger than the under-5 contacts previously prioritized. This would substantially increase the impact of household contact investigation on reducing TB morbidity and mortality. Funding: JMR is supported by the National Institute of Allergy and Infectious Diseases (K01 AI138620). This research was funded in part by a 2020 developmental grant from the University of Washington / Fred Hutch Center for AIDS Research, an NIH funded program under award number AI027757 which is supported by the following NIH Institutes and Centers: NIAID, NCI, NIMH, NIDA, NICHD, NHLBI, NIA, NIGMS, NIDDK. This work was funded in part by the National Science Foundation (DMS-1839116).Jennifer M. Ross, MDYongquan Xie, MSYaqi Wang, MSJames K. Collins, BSCody Horst, MPHJessie B. Doody, BAPaulina Lindstedt, MPHJorge R. Ledesma, MPHAdrienne E. Shapiro, PhDProf. Simon I. Hay, FMedSciHmwe H. Kyu, PhDAbraham D. Flaxman, PhDElsevierarticleMedicine (General)R5-920ENEClinicalMedicine, Vol 42, Iss , Pp 101206- (2021) |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Jennifer M. Ross, MD Yongquan Xie, MS Yaqi Wang, MS James K. Collins, BS Cody Horst, MPH Jessie B. Doody, BA Paulina Lindstedt, MPH Jorge R. Ledesma, MPH Adrienne E. Shapiro, PhD Prof. Simon I. Hay, FMedSci Hmwe H. Kyu, PhD Abraham D. Flaxman, PhD Estimating the population at high risk for tuberculosis through household exposure in high-incidence countries: a model-based analysis |
| description |
Background: Household contacts of people with pulmonary tuberculosis (TB) have greater risk of developing TB. Recent guidelines conditionally recommended TB preventive treatment (TPT) for household contacts of any age living in TB high-incidence countries, expanding earlier guidance to provide TPT to household contacts under five. The all-age population of household contacts has not been estimated. Methods: Our model-based estimation included 20 countries with >80% of incident TB globally in 2019. We developed country-specific distributions of household composition by age and sex using bootstrap resampling from health surveys and census data. We incorporated age-, sex-, year-, and location-specific estimates of pulmonary TB incidence from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 to estimate the population in each country sharing a household with someone with incident pulmonary TB, and quantified uncertainty using a Monte Carlo approach. Findings: We estimate that 38 million [95% uncertainty interval (UI) 33- 43 million] individuals lived in a household with someone with incident pulmonary TB in 2019 in these 20 countries. Children under five made up 12% of the population with household exposure, while adults were 65%. Zimbabwe, Mozambique, Zambia, and Pakistan had the highest proportion of the population with household exposure, while India had the highest number of contacts (11·4 million, 95% UI 9·7-13·4 million). Interpretation: Expanding TPT evaluation to household contacts of all ages in high-incidence countries could include a population more than 7-times larger than the under-5 contacts previously prioritized. This would substantially increase the impact of household contact investigation on reducing TB morbidity and mortality. Funding: JMR is supported by the National Institute of Allergy and Infectious Diseases (K01 AI138620). This research was funded in part by a 2020 developmental grant from the University of Washington / Fred Hutch Center for AIDS Research, an NIH funded program under award number AI027757 which is supported by the following NIH Institutes and Centers: NIAID, NCI, NIMH, NIDA, NICHD, NHLBI, NIA, NIGMS, NIDDK. This work was funded in part by the National Science Foundation (DMS-1839116). |
| format |
article |
| author |
Jennifer M. Ross, MD Yongquan Xie, MS Yaqi Wang, MS James K. Collins, BS Cody Horst, MPH Jessie B. Doody, BA Paulina Lindstedt, MPH Jorge R. Ledesma, MPH Adrienne E. Shapiro, PhD Prof. Simon I. Hay, FMedSci Hmwe H. Kyu, PhD Abraham D. Flaxman, PhD |
| author_facet |
Jennifer M. Ross, MD Yongquan Xie, MS Yaqi Wang, MS James K. Collins, BS Cody Horst, MPH Jessie B. Doody, BA Paulina Lindstedt, MPH Jorge R. Ledesma, MPH Adrienne E. Shapiro, PhD Prof. Simon I. Hay, FMedSci Hmwe H. Kyu, PhD Abraham D. Flaxman, PhD |
| author_sort |
Jennifer M. Ross, MD |
| title |
Estimating the population at high risk for tuberculosis through household exposure in high-incidence countries: a model-based analysis |
| title_short |
Estimating the population at high risk for tuberculosis through household exposure in high-incidence countries: a model-based analysis |
| title_full |
Estimating the population at high risk for tuberculosis through household exposure in high-incidence countries: a model-based analysis |
| title_fullStr |
Estimating the population at high risk for tuberculosis through household exposure in high-incidence countries: a model-based analysis |
| title_full_unstemmed |
Estimating the population at high risk for tuberculosis through household exposure in high-incidence countries: a model-based analysis |
| title_sort |
estimating the population at high risk for tuberculosis through household exposure in high-incidence countries: a model-based analysis |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/25d1cc1484a14152a547fbc809a5e30a |
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