IL-15 as a potential target in leukemia

Yu Xiong,1,2 Danièle Bensoussan,1,3 Véronique Decot1,3 1Cell Therapy Department, University Hospital of Nancy, Vandoeuvre les Nancy, France; 2Institute of Hepatobiliary Diseases, Transplant Center, Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation...

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Autores principales:	Xiong Y, Bensoussan D, Decot V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/25d20071d60649139a9a96ccb619a3b4
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spelling	oai:doaj.org-article:25d20071d60649139a9a96ccb619a3b42021-12-02T06:50:35ZIL-15 as a potential target in leukemia1179-9889https://doaj.org/article/25d20071d60649139a9a96ccb619a3b42015-04-01T00:00:00Zhttp://www.dovepress.com/il-15-as-a-potential-target-in-leukemia-peer-reviewed-article-BLCTThttps://doaj.org/toc/1179-9889 Yu Xiong,1,2 Danièle Bensoussan,1,3 Véronique Decot1,3 1Cell Therapy Department, University Hospital of Nancy, Vandoeuvre les Nancy, France; 2Institute of Hepatobiliary Diseases, Transplant Center, Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China; 3UMR CNRS UL 7365, Lorraine University, Vandoeuvre les Nancy, France Abstract: Leukemia, one of the most aggressive hematopoietic malignancies, is characterized by excessive proliferation, survival, and impaired differentiation of hematopoietic stem cells. Interleukin 15, a proinflammatory cytokine, induces proliferation and promotes cell survival of human T and B lymphocytes, as well as natural killer cells. However, it may also play a detrimental role in the onset of leukemia. This review provided an overview of the aberrant expression of Interleukin 15 and its role in the development and progression of this hematological malignancy. Also, we critically explored the potential therapeutic opportunities involved in targeting the disruption of interleukin-15 signaling as well as in interleukin-15-mediated enhancement of antitumor immunity. Keywords: leukemia, interleukin-15, immunotherapy Xiong YBensoussan DDecot VDove Medical PressarticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol 2015, Iss default, Pp 55-63 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Xiong Y Bensoussan D Decot V IL-15 as a potential target in leukemia
description	Yu Xiong,1,2 Danièle Bensoussan,1,3 Véronique Decot1,3 1Cell Therapy Department, University Hospital of Nancy, Vandoeuvre les Nancy, France; 2Institute of Hepatobiliary Diseases, Transplant Center, Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China; 3UMR CNRS UL 7365, Lorraine University, Vandoeuvre les Nancy, France Abstract: Leukemia, one of the most aggressive hematopoietic malignancies, is characterized by excessive proliferation, survival, and impaired differentiation of hematopoietic stem cells. Interleukin 15, a proinflammatory cytokine, induces proliferation and promotes cell survival of human T and B lymphocytes, as well as natural killer cells. However, it may also play a detrimental role in the onset of leukemia. This review provided an overview of the aberrant expression of Interleukin 15 and its role in the development and progression of this hematological malignancy. Also, we critically explored the potential therapeutic opportunities involved in targeting the disruption of interleukin-15 signaling as well as in interleukin-15-mediated enhancement of antitumor immunity. Keywords: leukemia, interleukin-15, immunotherapy
format	article
author	Xiong Y Bensoussan D Decot V
author_facet	Xiong Y Bensoussan D Decot V
author_sort	Xiong Y
title	IL-15 as a potential target in leukemia
title_short	IL-15 as a potential target in leukemia
title_full	IL-15 as a potential target in leukemia
title_fullStr	IL-15 as a potential target in leukemia
title_full_unstemmed	IL-15 as a potential target in leukemia
title_sort	il-15 as a potential target in leukemia
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/25d20071d60649139a9a96ccb619a3b4
work_keys_str_mv	AT xiongy il15asapotentialtargetinleukemia AT bensoussand il15asapotentialtargetinleukemia AT decotv il15asapotentialtargetinleukemia
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IL-15 as a potential target in leukemia

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