Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer

Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal transducers. They regulate essential cellular processes like proliferation, apoptosis, differentiation and metabolism. RTK alteration occurs in a broad spectrum of cancers, emphasising its crucial role in can...

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Autores principales:	Sareshma Sudhesh Dev, Syafiq Asnawi Zainal Abidin, Reyhaneh Farghadani, Iekhsan Othman, Rakesh Naidu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	curcumin receptor tyrosine kinase signaling pathway polyphenol combination therapy tyrosine kinase inhibitor Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/25d4ecd91baa456a9a96d874748a2051
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spelling	oai:doaj.org-article:25d4ecd91baa456a9a96d874748a20512021-11-15T06:19:00ZReceptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer1663-981210.3389/fphar.2021.772510https://doaj.org/article/25d4ecd91baa456a9a96d874748a20512021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.772510/fullhttps://doaj.org/toc/1663-9812Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal transducers. They regulate essential cellular processes like proliferation, apoptosis, differentiation and metabolism. RTK alteration occurs in a broad spectrum of cancers, emphasising its crucial role in cancer progression and as a suitable therapeutic target. The use of small molecule RTK inhibitors however, has been crippled by the emergence of resistance, highlighting the need for a pleiotropic anti-cancer agent that can replace or be used in combination with existing pharmacological agents to enhance treatment efficacy. Curcumin is an attractive therapeutic agent mainly due to its potent anti-cancer effects, extensive range of targets and minimal toxicity. Out of the numerous documented targets of curcumin, RTKs appear to be one of the main nodes of curcumin-mediated inhibition. Many studies have found that curcumin influences RTK activation and their downstream signaling pathways resulting in increased apoptosis, decreased proliferation and decreased migration in cancer both in vitro and in vivo. This review focused on how curcumin exhibits anti-cancer effects through inhibition of RTKs and downstream signaling pathways like the MAPK, PI3K/Akt, JAK/STAT, and NF-κB pathways. Combination studies of curcumin and RTK inhibitors were also analysed with emphasis on their common molecular targets.Sareshma Sudhesh DevSyafiq Asnawi Zainal AbidinReyhaneh FarghadaniIekhsan OthmanRakesh NaiduFrontiers Media S.A.articlecurcuminreceptor tyrosine kinasesignaling pathwaypolyphenolcombination therapytyrosine kinase inhibitorTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	curcumin receptor tyrosine kinase signaling pathway polyphenol combination therapy tyrosine kinase inhibitor Therapeutics. Pharmacology RM1-950
spellingShingle	curcumin receptor tyrosine kinase signaling pathway polyphenol combination therapy tyrosine kinase inhibitor Therapeutics. Pharmacology RM1-950 Sareshma Sudhesh Dev Syafiq Asnawi Zainal Abidin Reyhaneh Farghadani Iekhsan Othman Rakesh Naidu Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer
description	Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal transducers. They regulate essential cellular processes like proliferation, apoptosis, differentiation and metabolism. RTK alteration occurs in a broad spectrum of cancers, emphasising its crucial role in cancer progression and as a suitable therapeutic target. The use of small molecule RTK inhibitors however, has been crippled by the emergence of resistance, highlighting the need for a pleiotropic anti-cancer agent that can replace or be used in combination with existing pharmacological agents to enhance treatment efficacy. Curcumin is an attractive therapeutic agent mainly due to its potent anti-cancer effects, extensive range of targets and minimal toxicity. Out of the numerous documented targets of curcumin, RTKs appear to be one of the main nodes of curcumin-mediated inhibition. Many studies have found that curcumin influences RTK activation and their downstream signaling pathways resulting in increased apoptosis, decreased proliferation and decreased migration in cancer both in vitro and in vivo. This review focused on how curcumin exhibits anti-cancer effects through inhibition of RTKs and downstream signaling pathways like the MAPK, PI3K/Akt, JAK/STAT, and NF-κB pathways. Combination studies of curcumin and RTK inhibitors were also analysed with emphasis on their common molecular targets.
format	article
author	Sareshma Sudhesh Dev Syafiq Asnawi Zainal Abidin Reyhaneh Farghadani Iekhsan Othman Rakesh Naidu
author_facet	Sareshma Sudhesh Dev Syafiq Asnawi Zainal Abidin Reyhaneh Farghadani Iekhsan Othman Rakesh Naidu
author_sort	Sareshma Sudhesh Dev
title	Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer
title_short	Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer
title_full	Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer
title_fullStr	Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer
title_full_unstemmed	Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer
title_sort	receptor tyrosine kinases and their signaling pathways as therapeutic targets of curcumin in cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/25d4ecd91baa456a9a96d874748a2051
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Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer

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