Responsive Janus Structural Color Hydrogel Micromotors for Label-Free Multiplex Assays

Micromotors with self-propelling ability demonstrate great values in highly sensitive analysis. Developing novel micromotors to achieve label-free multiplex assay is particularly intriguing in terms of detection efficiency. Herein, structural color micromotors (SCMs) were developed and employed for...

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Autores principales:	Huan Wang, Lijun Cai, Dagan Zhang, Luoran Shang, Yuanjin Zhao
Formato:	article
Lenguaje:	EN
Publicado:	American Association for the Advancement of Science 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/25d9c5b8cb494291bf091ae7dd50e985
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spelling	oai:doaj.org-article:25d9c5b8cb494291bf091ae7dd50e9852021-11-29T08:35:09ZResponsive Janus Structural Color Hydrogel Micromotors for Label-Free Multiplex Assays2639-527410.34133/2021/9829068https://doaj.org/article/25d9c5b8cb494291bf091ae7dd50e9852021-01-01T00:00:00Zhttp://dx.doi.org/10.34133/2021/9829068https://doaj.org/toc/2639-5274Micromotors with self-propelling ability demonstrate great values in highly sensitive analysis. Developing novel micromotors to achieve label-free multiplex assay is particularly intriguing in terms of detection efficiency. Herein, structural color micromotors (SCMs) were developed and employed for this purpose. The SCMs were derived from phase separation of droplet templates and exhibited a Janus structure with two distinct sections, including one with structural colors and the other providing catalytic self-propelling functions. Besides, the SCMs were functionalized with ion-responsive aptamers, through which the interaction between the ions and aptamers resulted in the shift of the intrinsic color of the SCMs. It was demonstrated that the SCMs could realize multiplex label-free detection of ions based on their optical coding capacity and responsive behaviors. Moreover, the detection sensitivity was greatly improved benefiting from the autonomous motion of the SCMs which enhanced the ion-aptamer interactions. We anticipate that the SCMs can significantly promote the development of multiplex assay and biomedical fields.Huan WangLijun CaiDagan ZhangLuoran ShangYuanjin ZhaoAmerican Association for the Advancement of SciencearticleScienceQENResearch, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huan Wang Lijun Cai Dagan Zhang Luoran Shang Yuanjin Zhao Responsive Janus Structural Color Hydrogel Micromotors for Label-Free Multiplex Assays
description	Micromotors with self-propelling ability demonstrate great values in highly sensitive analysis. Developing novel micromotors to achieve label-free multiplex assay is particularly intriguing in terms of detection efficiency. Herein, structural color micromotors (SCMs) were developed and employed for this purpose. The SCMs were derived from phase separation of droplet templates and exhibited a Janus structure with two distinct sections, including one with structural colors and the other providing catalytic self-propelling functions. Besides, the SCMs were functionalized with ion-responsive aptamers, through which the interaction between the ions and aptamers resulted in the shift of the intrinsic color of the SCMs. It was demonstrated that the SCMs could realize multiplex label-free detection of ions based on their optical coding capacity and responsive behaviors. Moreover, the detection sensitivity was greatly improved benefiting from the autonomous motion of the SCMs which enhanced the ion-aptamer interactions. We anticipate that the SCMs can significantly promote the development of multiplex assay and biomedical fields.
format	article
author	Huan Wang Lijun Cai Dagan Zhang Luoran Shang Yuanjin Zhao
author_facet	Huan Wang Lijun Cai Dagan Zhang Luoran Shang Yuanjin Zhao
author_sort	Huan Wang
title	Responsive Janus Structural Color Hydrogel Micromotors for Label-Free Multiplex Assays
title_short	Responsive Janus Structural Color Hydrogel Micromotors for Label-Free Multiplex Assays
title_full	Responsive Janus Structural Color Hydrogel Micromotors for Label-Free Multiplex Assays
title_fullStr	Responsive Janus Structural Color Hydrogel Micromotors for Label-Free Multiplex Assays
title_full_unstemmed	Responsive Janus Structural Color Hydrogel Micromotors for Label-Free Multiplex Assays
title_sort	responsive janus structural color hydrogel micromotors for label-free multiplex assays
publisher	American Association for the Advancement of Science
publishDate	2021
url	https://doaj.org/article/25d9c5b8cb494291bf091ae7dd50e985
work_keys_str_mv	AT huanwang responsivejanusstructuralcolorhydrogelmicromotorsforlabelfreemultiplexassays AT lijuncai responsivejanusstructuralcolorhydrogelmicromotorsforlabelfreemultiplexassays AT daganzhang responsivejanusstructuralcolorhydrogelmicromotorsforlabelfreemultiplexassays AT luoranshang responsivejanusstructuralcolorhydrogelmicromotorsforlabelfreemultiplexassays AT yuanjinzhao responsivejanusstructuralcolorhydrogelmicromotorsforlabelfreemultiplexassays
_version_	1718407453436018688

Responsive Janus Structural Color Hydrogel Micromotors for Label-Free Multiplex Assays

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