The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas

Abstract The management of vestibular schwannoma (VS) with residual tumor following incomplete resection remains controversial and little is known regarding postoperative tumor volume changes. The behavior of residual tumors was analyzed for 111 patients who underwent surgery for newly diagnosed VS...

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Autores principales:	Hun Ho Park, So Hee Park, Hyeong-Cheol Oh, Hyun-Ho Jung, Jong Hee Chang, Kyu-Sung Lee, Won Seok Chang, Chang-Ki Hong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25dbbc403cc74094bb3049d2f17f90c3
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spelling	oai:doaj.org-article:25dbbc403cc74094bb3049d2f17f90c32021-12-02T13:30:51ZThe behavior of residual tumors following incomplete surgical resection for vestibular schwannomas10.1038/s41598-021-84319-12045-2322https://doaj.org/article/25dbbc403cc74094bb3049d2f17f90c32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84319-1https://doaj.org/toc/2045-2322Abstract The management of vestibular schwannoma (VS) with residual tumor following incomplete resection remains controversial and little is known regarding postoperative tumor volume changes. The behavior of residual tumors was analyzed for 111 patients who underwent surgery for newly diagnosed VS between September 2006 and July 2017. The postoperative tumor volume changes were assessed during a mean follow-up of 69 months (range 36–147 months). Fifty-three patients underwent imaging surveillance following incomplete resection. There was no residual tumor growth in 44 patients (83%). A significant regression of residual tumor volume was noted in the no growth group at postoperative 1 year (p = 0.028), 2 years (p = 0.012), but not from 3 years onwards. Significant predictors of regrowth were immediate postoperative tumor volume ≥ 0.7 cm3 (HR 10.5, p = 0.020) and residual tumor location other than the internal auditory canal (IAC) (HR 6.2, p = 0.026). The mean time to regrowth was 33 months (range 5–127 months). The 2-, 5-, and 10-year regrowth-free survival rates were 90.6%, 86.8%, and 83%, respectively. In conclusion, significant residual tumor regression could occur within 2 years for a VS with an immediate postoperative tumor volume less than 0.7 cm3 or residual tumor in IAC.Hun Ho ParkSo Hee ParkHyeong-Cheol OhHyun-Ho JungJong Hee ChangKyu-Sung LeeWon Seok ChangChang-Ki HongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hun Ho Park So Hee Park Hyeong-Cheol Oh Hyun-Ho Jung Jong Hee Chang Kyu-Sung Lee Won Seok Chang Chang-Ki Hong The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas
description	Abstract The management of vestibular schwannoma (VS) with residual tumor following incomplete resection remains controversial and little is known regarding postoperative tumor volume changes. The behavior of residual tumors was analyzed for 111 patients who underwent surgery for newly diagnosed VS between September 2006 and July 2017. The postoperative tumor volume changes were assessed during a mean follow-up of 69 months (range 36–147 months). Fifty-three patients underwent imaging surveillance following incomplete resection. There was no residual tumor growth in 44 patients (83%). A significant regression of residual tumor volume was noted in the no growth group at postoperative 1 year (p = 0.028), 2 years (p = 0.012), but not from 3 years onwards. Significant predictors of regrowth were immediate postoperative tumor volume ≥ 0.7 cm3 (HR 10.5, p = 0.020) and residual tumor location other than the internal auditory canal (IAC) (HR 6.2, p = 0.026). The mean time to regrowth was 33 months (range 5–127 months). The 2-, 5-, and 10-year regrowth-free survival rates were 90.6%, 86.8%, and 83%, respectively. In conclusion, significant residual tumor regression could occur within 2 years for a VS with an immediate postoperative tumor volume less than 0.7 cm3 or residual tumor in IAC.
format	article
author	Hun Ho Park So Hee Park Hyeong-Cheol Oh Hyun-Ho Jung Jong Hee Chang Kyu-Sung Lee Won Seok Chang Chang-Ki Hong
author_facet	Hun Ho Park So Hee Park Hyeong-Cheol Oh Hyun-Ho Jung Jong Hee Chang Kyu-Sung Lee Won Seok Chang Chang-Ki Hong
author_sort	Hun Ho Park
title	The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas
title_short	The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas
title_full	The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas
title_fullStr	The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas
title_full_unstemmed	The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas
title_sort	behavior of residual tumors following incomplete surgical resection for vestibular schwannomas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/25dbbc403cc74094bb3049d2f17f90c3
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The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas

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