No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men

Abstract Experimental evidence suggests a crucial role of the autonomic nervous system in whole body metabolism with major regulatory effects of the parasympathetic branch in postprandial adaptation. However, the relative contribution of this mechanism is still not fully clear in humans. We therefor...

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Autores principales: Andreas Vosseler, Dongxing Zhao, Louise Fritsche, Rainer Lehmann, Konstantinos Kantartzis, Dana M. Small, Andreas Peter, Hans-Ulrich Häring, Andreas L. Birkenfeld, Andreas Fritsche, Robert Wagner, Hubert Preißl, Stephanie Kullmann, Martin Heni
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Publicado: Nature Portfolio 2020
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spelling oai:doaj.org-article:25dc3cfb712440ad8931b977976f2e652021-12-02T15:09:48ZNo modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men10.1038/s41598-020-77430-22045-2322https://doaj.org/article/25dc3cfb712440ad8931b977976f2e652020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77430-2https://doaj.org/toc/2045-2322Abstract Experimental evidence suggests a crucial role of the autonomic nervous system in whole body metabolism with major regulatory effects of the parasympathetic branch in postprandial adaptation. However, the relative contribution of this mechanism is still not fully clear in humans. We therefore compared the effects of transcutaneous auricular vagus nerve stimulation (taVNS, Cerbomed Nemos) with sham stimulation during an oral glucose tolerance test in a randomized, single-blind, cross-over design in 15 healthy lean men. Stimulation was performed for 150 min, 30 min before and during the entire oral glucose tolerance test with stimulation cycles of 30 s of on-phase and 30 s of off-phase and a 25 Hz impulse. Heart rate variability and plasma catecholamine levels were assessed as proxies of autonomic tone in the periphery. Neither analyzed heart rate variability parameters nor plasma catecholamine levels were significantly different between the two conditions. Plasma glucose, insulin sensitivity and insulin secretion were also comparable between conditions. Thus, the applied taVNS device or protocol was unable to achieve significant effects on autonomic innervation in peripheral organs. Accordingly, glucose metabolism remained unaltered. Therefore, alternative approaches are necessary to investigate the importance of the autonomic nervous system in postprandial human metabolism.Andreas VosselerDongxing ZhaoLouise FritscheRainer LehmannKonstantinos KantartzisDana M. SmallAndreas PeterHans-Ulrich HäringAndreas L. BirkenfeldAndreas FritscheRobert WagnerHubert PreißlStephanie KullmannMartin HeniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Andreas Vosseler
Dongxing Zhao
Louise Fritsche
Rainer Lehmann
Konstantinos Kantartzis
Dana M. Small
Andreas Peter
Hans-Ulrich Häring
Andreas L. Birkenfeld
Andreas Fritsche
Robert Wagner
Hubert Preißl
Stephanie Kullmann
Martin Heni
No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
description Abstract Experimental evidence suggests a crucial role of the autonomic nervous system in whole body metabolism with major regulatory effects of the parasympathetic branch in postprandial adaptation. However, the relative contribution of this mechanism is still not fully clear in humans. We therefore compared the effects of transcutaneous auricular vagus nerve stimulation (taVNS, Cerbomed Nemos) with sham stimulation during an oral glucose tolerance test in a randomized, single-blind, cross-over design in 15 healthy lean men. Stimulation was performed for 150 min, 30 min before and during the entire oral glucose tolerance test with stimulation cycles of 30 s of on-phase and 30 s of off-phase and a 25 Hz impulse. Heart rate variability and plasma catecholamine levels were assessed as proxies of autonomic tone in the periphery. Neither analyzed heart rate variability parameters nor plasma catecholamine levels were significantly different between the two conditions. Plasma glucose, insulin sensitivity and insulin secretion were also comparable between conditions. Thus, the applied taVNS device or protocol was unable to achieve significant effects on autonomic innervation in peripheral organs. Accordingly, glucose metabolism remained unaltered. Therefore, alternative approaches are necessary to investigate the importance of the autonomic nervous system in postprandial human metabolism.
format article
author Andreas Vosseler
Dongxing Zhao
Louise Fritsche
Rainer Lehmann
Konstantinos Kantartzis
Dana M. Small
Andreas Peter
Hans-Ulrich Häring
Andreas L. Birkenfeld
Andreas Fritsche
Robert Wagner
Hubert Preißl
Stephanie Kullmann
Martin Heni
author_facet Andreas Vosseler
Dongxing Zhao
Louise Fritsche
Rainer Lehmann
Konstantinos Kantartzis
Dana M. Small
Andreas Peter
Hans-Ulrich Häring
Andreas L. Birkenfeld
Andreas Fritsche
Robert Wagner
Hubert Preißl
Stephanie Kullmann
Martin Heni
author_sort Andreas Vosseler
title No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
title_short No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
title_full No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
title_fullStr No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
title_full_unstemmed No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
title_sort no modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/25dc3cfb712440ad8931b977976f2e65
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