Non-invasive measurement of a metabolic marker of infant brain function

Abstract While near-infrared spectroscopy (NIRS) haemodynamic measures have proven to be vastly useful in investigating human brain development, the haemodynamic response function (HRF) in infants is not yet fully understood. NIRS measurements of the oxidation state of mitochondrial enzyme cytochrom...

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Autores principales:	Maheen F. Siddiqui, Sarah Lloyd-Fox, Pardis Kaynezhad, Ilias Tachtsidis, Mark H. Johnson, Clare E. Elwell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25dce678d2f54af9ae9901f6dc5506b0
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spelling	oai:doaj.org-article:25dce678d2f54af9ae9901f6dc5506b02021-12-02T15:04:53ZNon-invasive measurement of a metabolic marker of infant brain function10.1038/s41598-017-01394-z2045-2322https://doaj.org/article/25dce678d2f54af9ae9901f6dc5506b02017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01394-zhttps://doaj.org/toc/2045-2322Abstract While near-infrared spectroscopy (NIRS) haemodynamic measures have proven to be vastly useful in investigating human brain development, the haemodynamic response function (HRF) in infants is not yet fully understood. NIRS measurements of the oxidation state of mitochondrial enzyme cytochrome-c-oxidase (oxCCO) have the potential to yield key information about cellular oxygen utilisation and therefore energy metabolism. We used a broadband NIRS system to measure changes in oxCCO, in addition to haemodynamic changes, during functional activation in a group of 33 typically developing infants aged between 4 and 6 months. The responses were recorded over the right temporal lobe while the infants were presented with engaging videos containing social content. A significant increase in oxCCO was found in response to the social stimuli, with maximum increase of 0.238 ± 0.13 μM. These results are the first reported significant change in oxCCO in response to stimulus-evoked activation in human infants and open new vistas for investigating human infant brain function and its energy metabolism.Maheen F. SiddiquiSarah Lloyd-FoxPardis KaynezhadIlias TachtsidisMark H. JohnsonClare E. ElwellNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maheen F. Siddiqui Sarah Lloyd-Fox Pardis Kaynezhad Ilias Tachtsidis Mark H. Johnson Clare E. Elwell Non-invasive measurement of a metabolic marker of infant brain function
description	Abstract While near-infrared spectroscopy (NIRS) haemodynamic measures have proven to be vastly useful in investigating human brain development, the haemodynamic response function (HRF) in infants is not yet fully understood. NIRS measurements of the oxidation state of mitochondrial enzyme cytochrome-c-oxidase (oxCCO) have the potential to yield key information about cellular oxygen utilisation and therefore energy metabolism. We used a broadband NIRS system to measure changes in oxCCO, in addition to haemodynamic changes, during functional activation in a group of 33 typically developing infants aged between 4 and 6 months. The responses were recorded over the right temporal lobe while the infants were presented with engaging videos containing social content. A significant increase in oxCCO was found in response to the social stimuli, with maximum increase of 0.238 ± 0.13 μM. These results are the first reported significant change in oxCCO in response to stimulus-evoked activation in human infants and open new vistas for investigating human infant brain function and its energy metabolism.
format	article
author	Maheen F. Siddiqui Sarah Lloyd-Fox Pardis Kaynezhad Ilias Tachtsidis Mark H. Johnson Clare E. Elwell
author_facet	Maheen F. Siddiqui Sarah Lloyd-Fox Pardis Kaynezhad Ilias Tachtsidis Mark H. Johnson Clare E. Elwell
author_sort	Maheen F. Siddiqui
title	Non-invasive measurement of a metabolic marker of infant brain function
title_short	Non-invasive measurement of a metabolic marker of infant brain function
title_full	Non-invasive measurement of a metabolic marker of infant brain function
title_fullStr	Non-invasive measurement of a metabolic marker of infant brain function
title_full_unstemmed	Non-invasive measurement of a metabolic marker of infant brain function
title_sort	non-invasive measurement of a metabolic marker of infant brain function
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/25dce678d2f54af9ae9901f6dc5506b0
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Non-invasive measurement of a metabolic marker of infant brain function

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