Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure

A spatiotemporally dynamic therapy (SDT) is proposed as a powerful therapeutic modality that provides spatially dynamic responses of drug-carriers for adapting to the wound microenvironment. Herein, dynamic chitosan-poly (ethylene glycol) (CP) Schiff-base linkages are employed to perform SDT by dire...

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Autores principales:	Ya-nan Fu, Yongsan Li, Bo Deng, Yingjie Yu, Fang Liu, Lei Wang, Guang Chen, Lei Tao, Yen Wei, Xing Wang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Spatiotemporally dynamic therapy Drug-gel Shape-adaptive Tissue regeneration Ordered structure Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/25ddf6e4e13143348b611111a9db621c
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spelling	oai:doaj.org-article:25ddf6e4e13143348b611111a9db621c2021-11-04T04:35:23ZSpatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure2452-199X10.1016/j.bioactmat.2021.06.015https://doaj.org/article/25ddf6e4e13143348b611111a9db621c2022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003017https://doaj.org/toc/2452-199XA spatiotemporally dynamic therapy (SDT) is proposed as a powerful therapeutic modality that provides spatially dynamic responses of drug-carriers for adapting to the wound microenvironment. Herein, dynamic chitosan-poly (ethylene glycol) (CP) Schiff-base linkages are employed to perform SDT by directly converting a liquid drug Kangfuxin (KFX) into a gel formation. The obtained KFX-CP drug-gel with shape-adaptive property is used to treat a representative oral mucositis (OM) model in a spatiotemporally dynamic manner. The KFX-CP drug-gel creates an instructive microenvironment to regulate signaling biomolecules and endogenous cells behavior, thereby promoting OM healing by the rule of dynamically adjusting shape to fit the irregular OM regions first, and then provides space for tissue regeneration, over KFX potion control and the general hydrogel group of CP hydrogel and KFX-F127. Most interestingly, the regenerated tissue has ordered structure like healthy tissue. Therefore, the SDT provides a new approach for the design of next generation of wound dressing and tissue engineering materials.Ya-nan FuYongsan LiBo DengYingjie YuFang LiuLei WangGuang ChenLei TaoYen WeiXing WangKeAi Communications Co., Ltd.articleSpatiotemporally dynamic therapyDrug-gelShape-adaptiveTissue regenerationOrdered structureMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 165-176 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spatiotemporally dynamic therapy Drug-gel Shape-adaptive Tissue regeneration Ordered structure Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Spatiotemporally dynamic therapy Drug-gel Shape-adaptive Tissue regeneration Ordered structure Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Ya-nan Fu Yongsan Li Bo Deng Yingjie Yu Fang Liu Lei Wang Guang Chen Lei Tao Yen Wei Xing Wang Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure
description	A spatiotemporally dynamic therapy (SDT) is proposed as a powerful therapeutic modality that provides spatially dynamic responses of drug-carriers for adapting to the wound microenvironment. Herein, dynamic chitosan-poly (ethylene glycol) (CP) Schiff-base linkages are employed to perform SDT by directly converting a liquid drug Kangfuxin (KFX) into a gel formation. The obtained KFX-CP drug-gel with shape-adaptive property is used to treat a representative oral mucositis (OM) model in a spatiotemporally dynamic manner. The KFX-CP drug-gel creates an instructive microenvironment to regulate signaling biomolecules and endogenous cells behavior, thereby promoting OM healing by the rule of dynamically adjusting shape to fit the irregular OM regions first, and then provides space for tissue regeneration, over KFX potion control and the general hydrogel group of CP hydrogel and KFX-F127. Most interestingly, the regenerated tissue has ordered structure like healthy tissue. Therefore, the SDT provides a new approach for the design of next generation of wound dressing and tissue engineering materials.
format	article
author	Ya-nan Fu Yongsan Li Bo Deng Yingjie Yu Fang Liu Lei Wang Guang Chen Lei Tao Yen Wei Xing Wang
author_facet	Ya-nan Fu Yongsan Li Bo Deng Yingjie Yu Fang Liu Lei Wang Guang Chen Lei Tao Yen Wei Xing Wang
author_sort	Ya-nan Fu
title	Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure
title_short	Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure
title_full	Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure
title_fullStr	Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure
title_full_unstemmed	Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure
title_sort	spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/25ddf6e4e13143348b611111a9db621c
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Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure

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