An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
Multiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated with multiple alterations and worse outcomes.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/25de5d15c38f4468b633c9e4bdca4e8d |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:25de5d15c38f4468b633c9e4bdca4e8d |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:25de5d15c38f4468b633c9e4bdca4e8d2021-12-02T18:03:45ZAn integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer10.1038/s41467-021-22465-w2041-1723https://doaj.org/article/25de5d15c38f4468b633c9e4bdca4e8d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22465-whttps://doaj.org/toc/2041-1723Multiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated with multiple alterations and worse outcomes.Sia Viborg LindskrogFrederik PripPhilippe LamyAnn TaberClarice S. GroeneveldKarin Birkenkamp-DemtröderJørgen Bjerggaard JensenTrine StrandgaardIver NordentoftEmil ChristensenMateo SokacNicolai J. BirkbakLasse MarettyGregers G. HermannAstrid C. PetersenVeronika WeyererMarc-Oliver GrimmMarcus HorstmannGottfrid SjödahlMattias HöglundTorben SteinicheKarin MogensenAurélien de ReynièsRoman NawrothBrian JordanXiaoqi LinDejan DragicevicDouglas G. WardAnshita GoelCarolyn D. HurstJay D. RamanJoshua I. WarrickUlrika SegerstenDanijel SikicKim E. M. van KesselTobias MaurerJoshua J. MeeksDavid J. DeGraffRichard T. BryanMargaret A. KnowlesTatjana SimicArndt HartmannEllen C. ZwarthoffPer-Uno MalmströmNúria MalatsFrancisco X. RealLars DyrskjøtNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sia Viborg Lindskrog Frederik Prip Philippe Lamy Ann Taber Clarice S. Groeneveld Karin Birkenkamp-Demtröder Jørgen Bjerggaard Jensen Trine Strandgaard Iver Nordentoft Emil Christensen Mateo Sokac Nicolai J. Birkbak Lasse Maretty Gregers G. Hermann Astrid C. Petersen Veronika Weyerer Marc-Oliver Grimm Marcus Horstmann Gottfrid Sjödahl Mattias Höglund Torben Steiniche Karin Mogensen Aurélien de Reyniès Roman Nawroth Brian Jordan Xiaoqi Lin Dejan Dragicevic Douglas G. Ward Anshita Goel Carolyn D. Hurst Jay D. Raman Joshua I. Warrick Ulrika Segersten Danijel Sikic Kim E. M. van Kessel Tobias Maurer Joshua J. Meeks David J. DeGraff Richard T. Bryan Margaret A. Knowles Tatjana Simic Arndt Hartmann Ellen C. Zwarthoff Per-Uno Malmström Núria Malats Francisco X. Real Lars Dyrskjøt An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| description |
Multiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated with multiple alterations and worse outcomes. |
| format |
article |
| author |
Sia Viborg Lindskrog Frederik Prip Philippe Lamy Ann Taber Clarice S. Groeneveld Karin Birkenkamp-Demtröder Jørgen Bjerggaard Jensen Trine Strandgaard Iver Nordentoft Emil Christensen Mateo Sokac Nicolai J. Birkbak Lasse Maretty Gregers G. Hermann Astrid C. Petersen Veronika Weyerer Marc-Oliver Grimm Marcus Horstmann Gottfrid Sjödahl Mattias Höglund Torben Steiniche Karin Mogensen Aurélien de Reyniès Roman Nawroth Brian Jordan Xiaoqi Lin Dejan Dragicevic Douglas G. Ward Anshita Goel Carolyn D. Hurst Jay D. Raman Joshua I. Warrick Ulrika Segersten Danijel Sikic Kim E. M. van Kessel Tobias Maurer Joshua J. Meeks David J. DeGraff Richard T. Bryan Margaret A. Knowles Tatjana Simic Arndt Hartmann Ellen C. Zwarthoff Per-Uno Malmström Núria Malats Francisco X. Real Lars Dyrskjøt |
| author_facet |
Sia Viborg Lindskrog Frederik Prip Philippe Lamy Ann Taber Clarice S. Groeneveld Karin Birkenkamp-Demtröder Jørgen Bjerggaard Jensen Trine Strandgaard Iver Nordentoft Emil Christensen Mateo Sokac Nicolai J. Birkbak Lasse Maretty Gregers G. Hermann Astrid C. Petersen Veronika Weyerer Marc-Oliver Grimm Marcus Horstmann Gottfrid Sjödahl Mattias Höglund Torben Steiniche Karin Mogensen Aurélien de Reyniès Roman Nawroth Brian Jordan Xiaoqi Lin Dejan Dragicevic Douglas G. Ward Anshita Goel Carolyn D. Hurst Jay D. Raman Joshua I. Warrick Ulrika Segersten Danijel Sikic Kim E. M. van Kessel Tobias Maurer Joshua J. Meeks David J. DeGraff Richard T. Bryan Margaret A. Knowles Tatjana Simic Arndt Hartmann Ellen C. Zwarthoff Per-Uno Malmström Núria Malats Francisco X. Real Lars Dyrskjøt |
| author_sort |
Sia Viborg Lindskrog |
| title |
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| title_short |
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| title_full |
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| title_fullStr |
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| title_full_unstemmed |
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| title_sort |
integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/25de5d15c38f4468b633c9e4bdca4e8d |
| work_keys_str_mv |
AT siaviborglindskrog anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT frederikprip anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT philippelamy anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT anntaber anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT claricesgroeneveld anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT karinbirkenkampdemtroder anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT jørgenbjerggaardjensen anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT trinestrandgaard anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT ivernordentoft anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT emilchristensen anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT mateosokac anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT nicolaijbirkbak anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT lassemaretty anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT gregersghermann anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT astridcpetersen anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT veronikaweyerer anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT marcolivergrimm anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT marcushorstmann anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT gottfridsjodahl anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT mattiashoglund anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT torbensteiniche anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT karinmogensen anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT aureliendereynies anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT romannawroth anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT brianjordan anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT xiaoqilin anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT dejandragicevic anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT douglasgward anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT anshitagoel anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT carolyndhurst anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT jaydraman anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT joshuaiwarrick anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT ulrikasegersten anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT danijelsikic anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT kimemvankessel anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT tobiasmaurer anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT joshuajmeeks anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT davidjdegraff anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT richardtbryan anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT margaretaknowles anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT tatjanasimic anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT arndthartmann anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT ellenczwarthoff anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT perunomalmstrom anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT nuriamalats anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT franciscoxreal anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT larsdyrskjøt anintegratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT siaviborglindskrog integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT frederikprip integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT philippelamy integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT anntaber integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT claricesgroeneveld integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT karinbirkenkampdemtroder integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT jørgenbjerggaardjensen integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT trinestrandgaard integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT ivernordentoft integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT emilchristensen integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT mateosokac integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT nicolaijbirkbak integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT lassemaretty integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT gregersghermann integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT astridcpetersen integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT veronikaweyerer integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT marcolivergrimm integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT marcushorstmann integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT gottfridsjodahl integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT mattiashoglund integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT torbensteiniche integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT karinmogensen integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT aureliendereynies integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT romannawroth integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT brianjordan integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT xiaoqilin integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT dejandragicevic integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT douglasgward integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT anshitagoel integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT carolyndhurst integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT jaydraman integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT joshuaiwarrick integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT ulrikasegersten integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT danijelsikic integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT kimemvankessel integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT tobiasmaurer integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT joshuajmeeks integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT davidjdegraff integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT richardtbryan integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT margaretaknowles integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT tatjanasimic integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT arndthartmann integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT ellenczwarthoff integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT perunomalmstrom integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT nuriamalats integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT franciscoxreal integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer AT larsdyrskjøt integratedmultiomicsanalysisidentifiesprognosticmolecularsubtypesofnonmuscleinvasivebladdercancer |
| _version_ |
1718378677394210816 |