Assessments of iodoindoles and abamectin as inducers of methuosis in pinewood nematode, Bursaphelenchus xylophilus

Abstract Bursaphelenchus xylophilus is a quarantined migratory endoparasite known to cause severe economic losses in pine forest ecosystems. The study presents the nematicidal effects of halogenated indoles on B. xylophilus and their action mechanisms. 5-Iodoindole and abamectin (positive control) a...

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Autores principales:	Satish Kumar Rajasekharan, Jin-Hyung Lee, Vinothkannan Ravichandran, Jintae Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25dfb9ff27b8407eabbb5188c63574b2
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spelling	oai:doaj.org-article:25dfb9ff27b8407eabbb5188c63574b22021-12-02T12:32:06ZAssessments of iodoindoles and abamectin as inducers of methuosis in pinewood nematode, Bursaphelenchus xylophilus10.1038/s41598-017-07074-22045-2322https://doaj.org/article/25dfb9ff27b8407eabbb5188c63574b22017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07074-2https://doaj.org/toc/2045-2322Abstract Bursaphelenchus xylophilus is a quarantined migratory endoparasite known to cause severe economic losses in pine forest ecosystems. The study presents the nematicidal effects of halogenated indoles on B. xylophilus and their action mechanisms. 5-Iodoindole and abamectin (positive control) at low concentration (10 µg/mL) presented similar and high nematicidal activities against B. xylophilus. 5-Iodoindole diminished fecundity, reproductive activities, embryonic and juvenile lethality and locomotor behaviors. Molecular interactions of ligands with invertebrate-specific glutamate gated chloride channel receptor reinforced the notion that 5-iodoindole, like abamectin, rigidly binds to the active sites of the receptor. 5-Iodoindole also induced diverse phenotypic deformities in nematodes including abnormal organ disruption/shrinkage and increased vacuolization. These findings suggest the prospective role of vacuoles in nematode death by methuosis. Importantly, 5-iodoindole was nontoxic to two plants, Brassica oleracea and Raphanus raphanistrum. Henceforth, the study warrants the application of iodoindoles in ecological environments to control the devastating pine destruction by B. xylophilus.Satish Kumar RajasekharanJin-Hyung LeeVinothkannan RavichandranJintae LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Satish Kumar Rajasekharan Jin-Hyung Lee Vinothkannan Ravichandran Jintae Lee Assessments of iodoindoles and abamectin as inducers of methuosis in pinewood nematode, Bursaphelenchus xylophilus
description	Abstract Bursaphelenchus xylophilus is a quarantined migratory endoparasite known to cause severe economic losses in pine forest ecosystems. The study presents the nematicidal effects of halogenated indoles on B. xylophilus and their action mechanisms. 5-Iodoindole and abamectin (positive control) at low concentration (10 µg/mL) presented similar and high nematicidal activities against B. xylophilus. 5-Iodoindole diminished fecundity, reproductive activities, embryonic and juvenile lethality and locomotor behaviors. Molecular interactions of ligands with invertebrate-specific glutamate gated chloride channel receptor reinforced the notion that 5-iodoindole, like abamectin, rigidly binds to the active sites of the receptor. 5-Iodoindole also induced diverse phenotypic deformities in nematodes including abnormal organ disruption/shrinkage and increased vacuolization. These findings suggest the prospective role of vacuoles in nematode death by methuosis. Importantly, 5-iodoindole was nontoxic to two plants, Brassica oleracea and Raphanus raphanistrum. Henceforth, the study warrants the application of iodoindoles in ecological environments to control the devastating pine destruction by B. xylophilus.
format	article
author	Satish Kumar Rajasekharan Jin-Hyung Lee Vinothkannan Ravichandran Jintae Lee
author_facet	Satish Kumar Rajasekharan Jin-Hyung Lee Vinothkannan Ravichandran Jintae Lee
author_sort	Satish Kumar Rajasekharan
title	Assessments of iodoindoles and abamectin as inducers of methuosis in pinewood nematode, Bursaphelenchus xylophilus
title_short	Assessments of iodoindoles and abamectin as inducers of methuosis in pinewood nematode, Bursaphelenchus xylophilus
title_full	Assessments of iodoindoles and abamectin as inducers of methuosis in pinewood nematode, Bursaphelenchus xylophilus
title_fullStr	Assessments of iodoindoles and abamectin as inducers of methuosis in pinewood nematode, Bursaphelenchus xylophilus
title_full_unstemmed	Assessments of iodoindoles and abamectin as inducers of methuosis in pinewood nematode, Bursaphelenchus xylophilus
title_sort	assessments of iodoindoles and abamectin as inducers of methuosis in pinewood nematode, bursaphelenchus xylophilus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/25dfb9ff27b8407eabbb5188c63574b2
work_keys_str_mv	AT satishkumarrajasekharan assessmentsofiodoindolesandabamectinasinducersofmethuosisinpinewoodnematodebursaphelenchusxylophilus AT jinhyunglee assessmentsofiodoindolesandabamectinasinducersofmethuosisinpinewoodnematodebursaphelenchusxylophilus AT vinothkannanravichandran assessmentsofiodoindolesandabamectinasinducersofmethuosisinpinewoodnematodebursaphelenchusxylophilus AT jintaelee assessmentsofiodoindolesandabamectinasinducersofmethuosisinpinewoodnematodebursaphelenchusxylophilus
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Assessments of iodoindoles and abamectin as inducers of methuosis in pinewood nematode, Bursaphelenchus xylophilus

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