Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations

G protein-coupled receptors (GPCRs) are membrane receptors and are important drug targets, whose regulation by cations is poorly understood. Here authors use NMR to elucidate effects of cations on functional states of the GPCR, adenosine A2Areceptor (A2AR).

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Autores principales:	Libin Ye, Chris Neale, Adnan Sljoka, Brent Lyda, Dmitry Pichugin, Nobuyuki Tsuchimura, Sacha T. Larda, Régis Pomès, Angel E. García, Oliver P. Ernst, Roger K. Sunahara, R. Scott Prosser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/25e0679825f24b93877531f883a95c68
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spelling	oai:doaj.org-article:25e0679825f24b93877531f883a95c682021-12-02T16:49:49ZMechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations10.1038/s41467-018-03314-92041-1723https://doaj.org/article/25e0679825f24b93877531f883a95c682018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03314-9https://doaj.org/toc/2041-1723G protein-coupled receptors (GPCRs) are membrane receptors and are important drug targets, whose regulation by cations is poorly understood. Here authors use NMR to elucidate effects of cations on functional states of the GPCR, adenosine A2Areceptor (A2AR).Libin YeChris NealeAdnan SljokaBrent LydaDmitry PichuginNobuyuki TsuchimuraSacha T. LardaRégis PomèsAngel E. GarcíaOliver P. ErnstRoger K. SunaharaR. Scott ProsserNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Libin Ye Chris Neale Adnan Sljoka Brent Lyda Dmitry Pichugin Nobuyuki Tsuchimura Sacha T. Larda Régis Pomès Angel E. García Oliver P. Ernst Roger K. Sunahara R. Scott Prosser Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations
description	G protein-coupled receptors (GPCRs) are membrane receptors and are important drug targets, whose regulation by cations is poorly understood. Here authors use NMR to elucidate effects of cations on functional states of the GPCR, adenosine A2Areceptor (A2AR).
format	article
author	Libin Ye Chris Neale Adnan Sljoka Brent Lyda Dmitry Pichugin Nobuyuki Tsuchimura Sacha T. Larda Régis Pomès Angel E. García Oliver P. Ernst Roger K. Sunahara R. Scott Prosser
author_facet	Libin Ye Chris Neale Adnan Sljoka Brent Lyda Dmitry Pichugin Nobuyuki Tsuchimura Sacha T. Larda Régis Pomès Angel E. García Oliver P. Ernst Roger K. Sunahara R. Scott Prosser
author_sort	Libin Ye
title	Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations
title_short	Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations
title_full	Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations
title_fullStr	Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations
title_full_unstemmed	Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations
title_sort	mechanistic insights into allosteric regulation of the a2a adenosine g protein-coupled receptor by physiological cations
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/25e0679825f24b93877531f883a95c68
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Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations

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