Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations

G protein-coupled receptors (GPCRs) are membrane receptors and are important drug targets, whose regulation by cations is poorly understood. Here authors use NMR to elucidate effects of cations on functional states of the GPCR, adenosine A2Areceptor (A2AR).

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Autores principales: Libin Ye, Chris Neale, Adnan Sljoka, Brent Lyda, Dmitry Pichugin, Nobuyuki Tsuchimura, Sacha T. Larda, Régis Pomès, Angel E. García, Oliver P. Ernst, Roger K. Sunahara, R. Scott Prosser
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/25e0679825f24b93877531f883a95c68
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