Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction.

This study aimed to determine if 50 days of canola oil intake in the absence or presence of salt loading affects: (1) antioxidant and oxidative stress markers, (2) aortic mRNA of NADPH oxidase (NOX) subunits and superoxide dismutase (SOD) isoforms and (3) endothelial function in SHRSP rats. SHRSP ra...

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Autores principales:	Annateresa Papazzo, Xavier A Conlan, Louise Lexis, Fadi J Charchar, Paul A Lewandowski
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25e3863780e7498e868a9dcd797c299d
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spelling	oai:doaj.org-article:25e3863780e7498e868a9dcd797c299d2021-11-18T07:42:32ZSalt loading in canola oil fed SHRSP rats induces endothelial dysfunction.1932-620310.1371/journal.pone.0066655https://doaj.org/article/25e3863780e7498e868a9dcd797c299d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23762494/?tool=EBIhttps://doaj.org/toc/1932-6203This study aimed to determine if 50 days of canola oil intake in the absence or presence of salt loading affects: (1) antioxidant and oxidative stress markers, (2) aortic mRNA of NADPH oxidase (NOX) subunits and superoxide dismutase (SOD) isoforms and (3) endothelial function in SHRSP rats. SHRSP rats were fed a diet containing 10 wt/wt% soybean oil or 10 wt/wt% canola oil, and given tap water or water containing 1% NaCl for 50 days. Without salt, canola oil significantly increased RBC SOD, plasma cholesterol and triglycerides, aortic p22 (phox) , NOX2 and CuZn-SOD mRNA, and decreased RBC glutathione peroxidase activity. With salt, canola oil reduced RBC SOD and catalase activity, LDL-C, and p22 (phox) mRNA compared with canola oil alone, whereas plasma malondialdehyde (MDA) was reduced and RBC MDA and LDL-C were higher. With salt, the canola oil group had significantly reduced endothelium-dependent vasodilating responses to ACh and contractile responses to norepinephrine compared with the canola oil group without salt and to the WKY rats. These results indicate that ingestion of canola oil increases O2 (-) generation, and that canola oil ingestion in combination with salt leads to endothelial dysfunction in the SHRSP model.Annateresa PapazzoXavier A ConlanLouise LexisFadi J CharcharPaul A LewandowskiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e66655 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Annateresa Papazzo Xavier A Conlan Louise Lexis Fadi J Charchar Paul A Lewandowski Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction.
description	This study aimed to determine if 50 days of canola oil intake in the absence or presence of salt loading affects: (1) antioxidant and oxidative stress markers, (2) aortic mRNA of NADPH oxidase (NOX) subunits and superoxide dismutase (SOD) isoforms and (3) endothelial function in SHRSP rats. SHRSP rats were fed a diet containing 10 wt/wt% soybean oil or 10 wt/wt% canola oil, and given tap water or water containing 1% NaCl for 50 days. Without salt, canola oil significantly increased RBC SOD, plasma cholesterol and triglycerides, aortic p22 (phox) , NOX2 and CuZn-SOD mRNA, and decreased RBC glutathione peroxidase activity. With salt, canola oil reduced RBC SOD and catalase activity, LDL-C, and p22 (phox) mRNA compared with canola oil alone, whereas plasma malondialdehyde (MDA) was reduced and RBC MDA and LDL-C were higher. With salt, the canola oil group had significantly reduced endothelium-dependent vasodilating responses to ACh and contractile responses to norepinephrine compared with the canola oil group without salt and to the WKY rats. These results indicate that ingestion of canola oil increases O2 (-) generation, and that canola oil ingestion in combination with salt leads to endothelial dysfunction in the SHRSP model.
format	article
author	Annateresa Papazzo Xavier A Conlan Louise Lexis Fadi J Charchar Paul A Lewandowski
author_facet	Annateresa Papazzo Xavier A Conlan Louise Lexis Fadi J Charchar Paul A Lewandowski
author_sort	Annateresa Papazzo
title	Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction.
title_short	Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction.
title_full	Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction.
title_fullStr	Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction.
title_full_unstemmed	Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction.
title_sort	salt loading in canola oil fed shrsp rats induces endothelial dysfunction.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/25e3863780e7498e868a9dcd797c299d
work_keys_str_mv	AT annateresapapazzo saltloadingincanolaoilfedshrspratsinducesendothelialdysfunction AT xavieraconlan saltloadingincanolaoilfedshrspratsinducesendothelialdysfunction AT louiselexis saltloadingincanolaoilfedshrspratsinducesendothelialdysfunction AT fadijcharchar saltloadingincanolaoilfedshrspratsinducesendothelialdysfunction AT paulalewandowski saltloadingincanolaoilfedshrspratsinducesendothelialdysfunction
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Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction.

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