Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma

N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as transla...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Yue-fan Wang, Chun-mei Ge, Hao-zan Yin, Zhi-hui Dai, Jun-peng Dong, Man Ji, Fu Yang
Format: article
Langue:EN
Publié: Elsevier 2021
Sujets:
HCC
Accès en ligne:https://doaj.org/article/25e7777aa4be42af887a7cf0640d47c8
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
Description
Résumé:N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as translation, splicing, export and degradation. These processes are catalyzed by three types of prominent enzymes: writers, erasers and readers. Increasing evidence has shown that m6A modification is vital for the regulation of gene expression, carcinogenesis, tumor progression and other abnormal changes, and recent studies have shown that m6A is important in the development of hepatocellular carcinoma (HCC). Herein, we summarize the nature and regulatory mechanisms of m6A modification, including its role in the pathogenesis of HCC and related chronic liver diseases. We also highlight the clinical significance and future strategies involving RNA m6A modifications in HCC.