Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma

N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as transla...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yue-fan Wang, Chun-mei Ge, Hao-zan Yin, Zhi-hui Dai, Jun-peng Dong, Man Ji, Fu Yang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	N6-methyladenosine RNA m6A modification Chronic liver diseases HCC Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/25e7777aa4be42af887a7cf0640d47c8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:25e7777aa4be42af887a7cf0640d47c8
record_format	dspace
spelling	oai:doaj.org-article:25e7777aa4be42af887a7cf0640d47c82021-11-18T04:46:08ZDysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma1665-268110.1016/j.aohep.2021.100538https://doaj.org/article/25e7777aa4be42af887a7cf0640d47c82021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1665268121002374https://doaj.org/toc/1665-2681N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as translation, splicing, export and degradation. These processes are catalyzed by three types of prominent enzymes: writers, erasers and readers. Increasing evidence has shown that m6A modification is vital for the regulation of gene expression, carcinogenesis, tumor progression and other abnormal changes, and recent studies have shown that m6A is important in the development of hepatocellular carcinoma (HCC). Herein, we summarize the nature and regulatory mechanisms of m6A modification, including its role in the pathogenesis of HCC and related chronic liver diseases. We also highlight the clinical significance and future strategies involving RNA m6A modifications in HCC.Yue-fan WangChun-mei GeHao-zan YinZhi-hui DaiJun-peng DongMan JiFu YangElsevierarticleN6-methyladenosineRNA m6A modificationChronic liver diseasesHCCSpecialties of internal medicineRC581-951ENAnnals of Hepatology, Vol 25, Iss , Pp 100538- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	N6-methyladenosine RNA m6A modification Chronic liver diseases HCC Specialties of internal medicine RC581-951
spellingShingle	N6-methyladenosine RNA m6A modification Chronic liver diseases HCC Specialties of internal medicine RC581-951 Yue-fan Wang Chun-mei Ge Hao-zan Yin Zhi-hui Dai Jun-peng Dong Man Ji Fu Yang Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma
description	N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as translation, splicing, export and degradation. These processes are catalyzed by three types of prominent enzymes: writers, erasers and readers. Increasing evidence has shown that m6A modification is vital for the regulation of gene expression, carcinogenesis, tumor progression and other abnormal changes, and recent studies have shown that m6A is important in the development of hepatocellular carcinoma (HCC). Herein, we summarize the nature and regulatory mechanisms of m6A modification, including its role in the pathogenesis of HCC and related chronic liver diseases. We also highlight the clinical significance and future strategies involving RNA m6A modifications in HCC.
format	article
author	Yue-fan Wang Chun-mei Ge Hao-zan Yin Zhi-hui Dai Jun-peng Dong Man Ji Fu Yang
author_facet	Yue-fan Wang Chun-mei Ge Hao-zan Yin Zhi-hui Dai Jun-peng Dong Man Ji Fu Yang
author_sort	Yue-fan Wang
title	Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma
title_short	Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma
title_full	Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma
title_fullStr	Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma
title_full_unstemmed	Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma
title_sort	dysregulated n6-methyladenosine (m6a) processing in hepatocellular carcinoma
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/25e7777aa4be42af887a7cf0640d47c8
work_keys_str_mv	AT yuefanwang dysregulatedn6methyladenosinem6aprocessinginhepatocellularcarcinoma AT chunmeige dysregulatedn6methyladenosinem6aprocessinginhepatocellularcarcinoma AT haozanyin dysregulatedn6methyladenosinem6aprocessinginhepatocellularcarcinoma AT zhihuidai dysregulatedn6methyladenosinem6aprocessinginhepatocellularcarcinoma AT junpengdong dysregulatedn6methyladenosinem6aprocessinginhepatocellularcarcinoma AT manji dysregulatedn6methyladenosinem6aprocessinginhepatocellularcarcinoma AT fuyang dysregulatedn6methyladenosinem6aprocessinginhepatocellularcarcinoma
_version_	1718425027708190720

Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma

Ejemplares similares