Polymorphism of genes-candidates of renin-angiotensin-aldosteronovy system (ACE, AGT, AGTR1) and effectiveness of treatment of arterial hypertension. Results of research in Mountain Shoria

Aim. To study the dependence of the effectiveness of antihypertensive therapy on the polymorphic variants of candidate genes of the RAAS (ACE, AGT, AGTR1) in patients with hypertension (АH) of the population of Mountain Shoria. Materials and methods. In the conditions of the expeditions from 2013...

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Autores principales:	Tatyana A. Mulerova, Natalia I. Morozova, Vladimir N. Maksimov, Mikhail Yu. Ogarkov
Formato:	article
Lenguaje:	RU
Publicado:	IP Morozov P.V. 2021
Materias:	ethnos antihypertensive therapy treatment efficacy renin-angiotensin-aldosterone system Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/25e829ea4ac149008e785ee6a76019dc
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spelling	oai:doaj.org-article:25e829ea4ac149008e785ee6a76019dc2021-11-30T16:09:16ZPolymorphism of genes-candidates of renin-angiotensin-aldosteronovy system (ACE, AGT, AGTR1) and effectiveness of treatment of arterial hypertension. Results of research in Mountain Shoria2075-082X2542-218910.26442/2075082X.2020.4.200034https://doaj.org/article/25e829ea4ac149008e785ee6a76019dc2021-02-01T00:00:00Zhttps://syst-hypertension.ru/2075-082X/article/viewFile/60283/43452https://doaj.org/toc/2075-082Xhttps://doaj.org/toc/2542-2189Aim. To study the dependence of the effectiveness of antihypertensive therapy on the polymorphic variants of candidate genes of the RAAS (ACE, AGT, AGTR1) in patients with hypertension (АH) of the population of Mountain Shoria. Materials and methods. In the conditions of the expeditions from 2013 to 2017, the population of Mountain Shoria was surveyed. Included 1409 people 18 years and older. Blood pressure monitoring was carried out as a result of office measurement, according to the standard recommendations of National Guidelines of the Russian Society of Cardiology/the Russian Medical Society on Arterial Hypertension (2010). As a result of the survey, patients with AH were identified for further observation (597 people) who need medical antihypertensive treatment. Repeat screening was conducted in a year. The criterion for inclusion in prospective observation of patients with hypertension was: regular intake of prescribed medication. 253 respondents were surveyed: indigenous (156 people) and non-indigenous (97 people) nationality. All patients underwent a standard examination, including the collection of complaints and anamnesis, an assessment of objective status, laboratory and instrumental studies. Polymorphisms of genes ACE (I/D, rs 4340), AGT (c.803T C, rs699), AGTR1 (A1166C, rs5186) were tested using polymerase chain reaction. Results. Dynamic observation of patients with hypertension found that in the cohort of Shors the target level of blood pressure reached the owners of heterozygous I/D and minor D/D genotypes of the ACE gene, carriers of T/C and C/C genotypes of the AGT gene and the homozygous genotype A/A of the AGTR1 gene. In the non-indigenous nationality cohort, only carriers of the D/D genotype of the ACE gene. Conclusion. National differences were identified with respect to the sensitivity of the pharmacological response to treatment, which once again proves the important role of taking into account the ethnic factor in the choice of drug.Tatyana A. MulerovaNatalia I. MorozovaVladimir N. MaksimovMikhail Yu. OgarkovIP Morozov P.V.articleethnosantihypertensive therapytreatment efficacyrenin-angiotensin-aldosterone systemDiseases of the circulatory (Cardiovascular) systemRC666-701RUСистемные гипертензии, Vol 17, Iss 4, Pp 49-54 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	ethnos antihypertensive therapy treatment efficacy renin-angiotensin-aldosterone system Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	ethnos antihypertensive therapy treatment efficacy renin-angiotensin-aldosterone system Diseases of the circulatory (Cardiovascular) system RC666-701 Tatyana A. Mulerova Natalia I. Morozova Vladimir N. Maksimov Mikhail Yu. Ogarkov Polymorphism of genes-candidates of renin-angiotensin-aldosteronovy system (ACE, AGT, AGTR1) and effectiveness of treatment of arterial hypertension. Results of research in Mountain Shoria
description	Aim. To study the dependence of the effectiveness of antihypertensive therapy on the polymorphic variants of candidate genes of the RAAS (ACE, AGT, AGTR1) in patients with hypertension (АH) of the population of Mountain Shoria. Materials and methods. In the conditions of the expeditions from 2013 to 2017, the population of Mountain Shoria was surveyed. Included 1409 people 18 years and older. Blood pressure monitoring was carried out as a result of office measurement, according to the standard recommendations of National Guidelines of the Russian Society of Cardiology/the Russian Medical Society on Arterial Hypertension (2010). As a result of the survey, patients with AH were identified for further observation (597 people) who need medical antihypertensive treatment. Repeat screening was conducted in a year. The criterion for inclusion in prospective observation of patients with hypertension was: regular intake of prescribed medication. 253 respondents were surveyed: indigenous (156 people) and non-indigenous (97 people) nationality. All patients underwent a standard examination, including the collection of complaints and anamnesis, an assessment of objective status, laboratory and instrumental studies. Polymorphisms of genes ACE (I/D, rs 4340), AGT (c.803T C, rs699), AGTR1 (A1166C, rs5186) were tested using polymerase chain reaction. Results. Dynamic observation of patients with hypertension found that in the cohort of Shors the target level of blood pressure reached the owners of heterozygous I/D and minor D/D genotypes of the ACE gene, carriers of T/C and C/C genotypes of the AGT gene and the homozygous genotype A/A of the AGTR1 gene. In the non-indigenous nationality cohort, only carriers of the D/D genotype of the ACE gene. Conclusion. National differences were identified with respect to the sensitivity of the pharmacological response to treatment, which once again proves the important role of taking into account the ethnic factor in the choice of drug.
format	article
author	Tatyana A. Mulerova Natalia I. Morozova Vladimir N. Maksimov Mikhail Yu. Ogarkov
author_facet	Tatyana A. Mulerova Natalia I. Morozova Vladimir N. Maksimov Mikhail Yu. Ogarkov
author_sort	Tatyana A. Mulerova
title	Polymorphism of genes-candidates of renin-angiotensin-aldosteronovy system (ACE, AGT, AGTR1) and effectiveness of treatment of arterial hypertension. Results of research in Mountain Shoria
title_short	Polymorphism of genes-candidates of renin-angiotensin-aldosteronovy system (ACE, AGT, AGTR1) and effectiveness of treatment of arterial hypertension. Results of research in Mountain Shoria
title_full	Polymorphism of genes-candidates of renin-angiotensin-aldosteronovy system (ACE, AGT, AGTR1) and effectiveness of treatment of arterial hypertension. Results of research in Mountain Shoria
title_fullStr	Polymorphism of genes-candidates of renin-angiotensin-aldosteronovy system (ACE, AGT, AGTR1) and effectiveness of treatment of arterial hypertension. Results of research in Mountain Shoria
title_full_unstemmed	Polymorphism of genes-candidates of renin-angiotensin-aldosteronovy system (ACE, AGT, AGTR1) and effectiveness of treatment of arterial hypertension. Results of research in Mountain Shoria
title_sort	polymorphism of genes-candidates of renin-angiotensin-aldosteronovy system (ace, agt, agtr1) and effectiveness of treatment of arterial hypertension. results of research in mountain shoria
publisher	IP Morozov P.V.
publishDate	2021
url	https://doaj.org/article/25e829ea4ac149008e785ee6a76019dc
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Polymorphism of genes-candidates of renin-angiotensin-aldosteronovy system (ACE, AGT, AGTR1) and effectiveness of treatment of arterial hypertension. Results of research in Mountain Shoria

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