A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

Class F receptors are therapeutic targets in human disease and understanding their structural changes during receptor activation may provide important pharmacological insight. Here, the authors combine computational and experimental methods to identify a molecular switch in TM6/7 of Class F receptor...

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Autores principales:	Shane C. Wright, Paweł Kozielewicz, Maria Kowalski-Jahn, Julian Petersen, Carl-Fredrik Bowin, Greg Slodkowicz, Maria Marti-Solano, David Rodríguez, Belma Hot, Najeah Okashah, Katerina Strakova, Jana Valnohova, M. Madan Babu, Nevin A. Lambert, Jens Carlsson, Gunnar Schulte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/25eb2e5a80d940629421bb3eaf96fb01
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spelling	oai:doaj.org-article:25eb2e5a80d940629421bb3eaf96fb012021-12-02T16:57:20ZA conserved molecular switch in Class F receptors regulates receptor activation and pathway selection10.1038/s41467-019-08630-22041-1723https://doaj.org/article/25eb2e5a80d940629421bb3eaf96fb012019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08630-2https://doaj.org/toc/2041-1723Class F receptors are therapeutic targets in human disease and understanding their structural changes during receptor activation may provide important pharmacological insight. Here, the authors combine computational and experimental methods to identify a molecular switch in TM6/7 of Class F receptors that mediates receptor activation.Shane C. WrightPaweł KozielewiczMaria Kowalski-JahnJulian PetersenCarl-Fredrik BowinGreg SlodkowiczMaria Marti-SolanoDavid RodríguezBelma HotNajeah OkashahKaterina StrakovaJana ValnohovaM. Madan BabuNevin A. LambertJens CarlssonGunnar SchulteNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shane C. Wright Paweł Kozielewicz Maria Kowalski-Jahn Julian Petersen Carl-Fredrik Bowin Greg Slodkowicz Maria Marti-Solano David Rodríguez Belma Hot Najeah Okashah Katerina Strakova Jana Valnohova M. Madan Babu Nevin A. Lambert Jens Carlsson Gunnar Schulte A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection
description	Class F receptors are therapeutic targets in human disease and understanding their structural changes during receptor activation may provide important pharmacological insight. Here, the authors combine computational and experimental methods to identify a molecular switch in TM6/7 of Class F receptors that mediates receptor activation.
format	article
author	Shane C. Wright Paweł Kozielewicz Maria Kowalski-Jahn Julian Petersen Carl-Fredrik Bowin Greg Slodkowicz Maria Marti-Solano David Rodríguez Belma Hot Najeah Okashah Katerina Strakova Jana Valnohova M. Madan Babu Nevin A. Lambert Jens Carlsson Gunnar Schulte
author_facet	Shane C. Wright Paweł Kozielewicz Maria Kowalski-Jahn Julian Petersen Carl-Fredrik Bowin Greg Slodkowicz Maria Marti-Solano David Rodríguez Belma Hot Najeah Okashah Katerina Strakova Jana Valnohova M. Madan Babu Nevin A. Lambert Jens Carlsson Gunnar Schulte
author_sort	Shane C. Wright
title	A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection
title_short	A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection
title_full	A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection
title_fullStr	A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection
title_full_unstemmed	A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection
title_sort	conserved molecular switch in class f receptors regulates receptor activation and pathway selection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/25eb2e5a80d940629421bb3eaf96fb01
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A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

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