Hepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis

Visceral leishmaniasis (VL) is the most severe form of leishmaniasis caused by protozoan parasites of the genus <i>Leishmania</i>. Hepatomegaly is one of the most frequent clinical manifestations of VL, whereas immunopathology of the symptom has not been well investigated. Using our chro...

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Autores principales:	Kota Maeda, Sonya Sadoughi, Ayako Morimoto, Kazuyuki Uchida, James K. Chambers, Chizu Sanjoba, Junya Yamagishi, Yasuyuki Goto
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	visceral leishmaniasis hepatomegaly sinusoid edema Medicine R
Acceso en línea:	https://doaj.org/article/25eb3461a252455081696a7d368db9ae
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spelling	oai:doaj.org-article:25eb3461a252455081696a7d368db9ae2021-11-25T18:37:33ZHepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis10.3390/pathogens101113562076-0817https://doaj.org/article/25eb3461a252455081696a7d368db9ae2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1356https://doaj.org/toc/2076-0817Visceral leishmaniasis (VL) is the most severe form of leishmaniasis caused by protozoan parasites of the genus <i>Leishmania</i>. Hepatomegaly is one of the most frequent clinical manifestations of VL, whereas immunopathology of the symptom has not been well investigated. Using our chronic model of experimental VL, we examined the influence of <i>Leishmania donovani</i> infection on the liver by clinical, histological, and biochemical analyses. The infected mice showed increased liver weight 24 weeks post-infection. Although an increase in serum ALT and inflammatory cell accumulation were observed in the livers of infected mice, no apparent parenchymal necrosis or fibrosis was observed. Tissue water content analyses demonstrated that increased liver weight was predominantly due to an increase in water weight. Together with the finding of hepatic sinusoidal dilation, these results suggested that edema associated with sinusoidal dilation causes hepatomegaly in <i>L. donovani</i> infection. Immunostaining of platelets and erythrocytes showed no thrombus formation or damage to the sinusoidal endothelium in the liver of infected mice. Taken together, these results suggest that hepatomegaly during experimental VL is caused by non-obstructive sinusoidal dilation.Kota MaedaSonya SadoughiAyako MorimotoKazuyuki UchidaJames K. ChambersChizu SanjobaJunya YamagishiYasuyuki GotoMDPI AGarticlevisceral leishmaniasishepatomegalysinusoidedemaMedicineRENPathogens, Vol 10, Iss 1356, p 1356 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	visceral leishmaniasis hepatomegaly sinusoid edema Medicine R
spellingShingle	visceral leishmaniasis hepatomegaly sinusoid edema Medicine R Kota Maeda Sonya Sadoughi Ayako Morimoto Kazuyuki Uchida James K. Chambers Chizu Sanjoba Junya Yamagishi Yasuyuki Goto Hepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis
description	Visceral leishmaniasis (VL) is the most severe form of leishmaniasis caused by protozoan parasites of the genus <i>Leishmania</i>. Hepatomegaly is one of the most frequent clinical manifestations of VL, whereas immunopathology of the symptom has not been well investigated. Using our chronic model of experimental VL, we examined the influence of <i>Leishmania donovani</i> infection on the liver by clinical, histological, and biochemical analyses. The infected mice showed increased liver weight 24 weeks post-infection. Although an increase in serum ALT and inflammatory cell accumulation were observed in the livers of infected mice, no apparent parenchymal necrosis or fibrosis was observed. Tissue water content analyses demonstrated that increased liver weight was predominantly due to an increase in water weight. Together with the finding of hepatic sinusoidal dilation, these results suggested that edema associated with sinusoidal dilation causes hepatomegaly in <i>L. donovani</i> infection. Immunostaining of platelets and erythrocytes showed no thrombus formation or damage to the sinusoidal endothelium in the liver of infected mice. Taken together, these results suggest that hepatomegaly during experimental VL is caused by non-obstructive sinusoidal dilation.
format	article
author	Kota Maeda Sonya Sadoughi Ayako Morimoto Kazuyuki Uchida James K. Chambers Chizu Sanjoba Junya Yamagishi Yasuyuki Goto
author_facet	Kota Maeda Sonya Sadoughi Ayako Morimoto Kazuyuki Uchida James K. Chambers Chizu Sanjoba Junya Yamagishi Yasuyuki Goto
author_sort	Kota Maeda
title	Hepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis
title_short	Hepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis
title_full	Hepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis
title_fullStr	Hepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis
title_full_unstemmed	Hepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis
title_sort	hepatomegaly associated with non-obstructive sinusoidal dilation in experimental visceral leishmaniasis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/25eb3461a252455081696a7d368db9ae
work_keys_str_mv	AT kotamaeda hepatomegalyassociatedwithnonobstructivesinusoidaldilationinexperimentalvisceralleishmaniasis AT sonyasadoughi hepatomegalyassociatedwithnonobstructivesinusoidaldilationinexperimentalvisceralleishmaniasis AT ayakomorimoto hepatomegalyassociatedwithnonobstructivesinusoidaldilationinexperimentalvisceralleishmaniasis AT kazuyukiuchida hepatomegalyassociatedwithnonobstructivesinusoidaldilationinexperimentalvisceralleishmaniasis AT jameskchambers hepatomegalyassociatedwithnonobstructivesinusoidaldilationinexperimentalvisceralleishmaniasis AT chizusanjoba hepatomegalyassociatedwithnonobstructivesinusoidaldilationinexperimentalvisceralleishmaniasis AT junyayamagishi hepatomegalyassociatedwithnonobstructivesinusoidaldilationinexperimentalvisceralleishmaniasis AT yasuyukigoto hepatomegalyassociatedwithnonobstructivesinusoidaldilationinexperimentalvisceralleishmaniasis
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Hepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis

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