COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants

Emerging SARS-CoV-2 variants contain mutations in the spike protein that may affect vaccine efficacy. Here, Jalkanen et al. show, using sera from 180 BNT162b2-vaccinated health care workers, that neutralization of SARS-CoV2 variant B.1.1.7 is not affected, while neutralization of B.1.351 variant is...

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Autores principales:	Pinja Jalkanen, Pekka Kolehmainen, Hanni K. Häkkinen, Moona Huttunen, Paula A. Tähtinen, Rickard Lundberg, Sari Maljanen, Arttu Reinholm, Sisko Tauriainen, Sari H. Pakkanen, Iris Levonen, Arttu Nousiainen, Taru Miller, Hanna Välimaa, Lauri Ivaska, Arja Pasternack, Rauno Naves, Olli Ritvos, Pamela Österlund, Suvi Kuivanen, Teemu Smura, Jussi Hepojoki, Olli Vapalahti, Johanna Lempainen, Laura Kakkola, Anu Kantele, Ilkka Julkunen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/25eba529c54644f1ab78c9de70f9aea6
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spelling	oai:doaj.org-article:25eba529c54644f1ab78c9de70f9aea62021-12-02T18:18:35ZCOVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants10.1038/s41467-021-24285-42041-1723https://doaj.org/article/25eba529c54644f1ab78c9de70f9aea62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24285-4https://doaj.org/toc/2041-1723Emerging SARS-CoV-2 variants contain mutations in the spike protein that may affect vaccine efficacy. Here, Jalkanen et al. show, using sera from 180 BNT162b2-vaccinated health care workers, that neutralization of SARS-CoV2 variant B.1.1.7 is not affected, while neutralization of B.1.351 variant is five-fold reduced.Pinja JalkanenPekka KolehmainenHanni K. HäkkinenMoona HuttunenPaula A. TähtinenRickard LundbergSari MaljanenArttu ReinholmSisko TauriainenSari H. PakkanenIris LevonenArttu NousiainenTaru MillerHanna VälimaaLauri IvaskaArja PasternackRauno NavesOlli RitvosPamela ÖsterlundSuvi KuivanenTeemu SmuraJussi HepojokiOlli VapalahtiJohanna LempainenLaura KakkolaAnu KanteleIlkka JulkunenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pinja Jalkanen Pekka Kolehmainen Hanni K. Häkkinen Moona Huttunen Paula A. Tähtinen Rickard Lundberg Sari Maljanen Arttu Reinholm Sisko Tauriainen Sari H. Pakkanen Iris Levonen Arttu Nousiainen Taru Miller Hanna Välimaa Lauri Ivaska Arja Pasternack Rauno Naves Olli Ritvos Pamela Österlund Suvi Kuivanen Teemu Smura Jussi Hepojoki Olli Vapalahti Johanna Lempainen Laura Kakkola Anu Kantele Ilkka Julkunen COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants
description	Emerging SARS-CoV-2 variants contain mutations in the spike protein that may affect vaccine efficacy. Here, Jalkanen et al. show, using sera from 180 BNT162b2-vaccinated health care workers, that neutralization of SARS-CoV2 variant B.1.1.7 is not affected, while neutralization of B.1.351 variant is five-fold reduced.
format	article
author	Pinja Jalkanen Pekka Kolehmainen Hanni K. Häkkinen Moona Huttunen Paula A. Tähtinen Rickard Lundberg Sari Maljanen Arttu Reinholm Sisko Tauriainen Sari H. Pakkanen Iris Levonen Arttu Nousiainen Taru Miller Hanna Välimaa Lauri Ivaska Arja Pasternack Rauno Naves Olli Ritvos Pamela Österlund Suvi Kuivanen Teemu Smura Jussi Hepojoki Olli Vapalahti Johanna Lempainen Laura Kakkola Anu Kantele Ilkka Julkunen
author_facet	Pinja Jalkanen Pekka Kolehmainen Hanni K. Häkkinen Moona Huttunen Paula A. Tähtinen Rickard Lundberg Sari Maljanen Arttu Reinholm Sisko Tauriainen Sari H. Pakkanen Iris Levonen Arttu Nousiainen Taru Miller Hanna Välimaa Lauri Ivaska Arja Pasternack Rauno Naves Olli Ritvos Pamela Österlund Suvi Kuivanen Teemu Smura Jussi Hepojoki Olli Vapalahti Johanna Lempainen Laura Kakkola Anu Kantele Ilkka Julkunen
author_sort	Pinja Jalkanen
title	COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants
title_short	COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants
title_full	COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants
title_fullStr	COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants
title_full_unstemmed	COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants
title_sort	covid-19 mrna vaccine induced antibody responses against three sars-cov-2 variants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/25eba529c54644f1ab78c9de70f9aea6
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COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants

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