Exposure to metals and morbidity at eight years follow-up in women of childbearing age

Abstract This exploratory study was aimed to investigate the link between toxic metal content in women’s urine and their morbidity 2 years before and 6 years after the test. Concentrations of 25 metals in urine were analyzed for 111 pregnant women collected prior to delivery. All women were of Arab-...

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Autores principales:	Isabella Karakis, Yael Baumfeld, Daniella Landau, Roni Gat, Nofar Shemesh, Maayan Yitshak-Sade, Ofir Tirosh, Batia Sarov, Lena Novack
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25f25403c0544771851c61e3f9422d2c
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spelling	oai:doaj.org-article:25f25403c0544771851c61e3f9422d2c2021-12-02T15:56:49ZExposure to metals and morbidity at eight years follow-up in women of childbearing age10.1038/s41598-021-90904-12045-2322https://doaj.org/article/25f25403c0544771851c61e3f9422d2c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90904-1https://doaj.org/toc/2045-2322Abstract This exploratory study was aimed to investigate the link between toxic metal content in women’s urine and their morbidity 2 years before and 6 years after the test. Concentrations of 25 metals in urine were analyzed for 111 pregnant women collected prior to delivery. All women were of Arab-Bedouin origin. Information on primary care and hospital visits during the study period was obtained. In a Poisson regression model, a health outcome was regressed over metal exposure and other factors. A Weighted Quantile Sum Regression (WQS) approach was used to indicate metals dominating in their possible impact on women's morbidity. Obesity was the most frequently diagnosed condition in this population (27.9%). Diagnoses in a neurological category accounted for 36.0%, asthma or respiratory—25.2%, psychiatric—12.6%, cardiovascular—14.4% and cancer or benign growth—for 13.5%. Based on WQS analysis, cancer and benign growth were mostly attributed to the increased levels of cadmium, cardiovascular outcomes were linked with lead, and obesity was found associated with elevated levels of nickel. Hematological, neurological and respiratory outcomes were attributed to multiple non-essential metals. The health and exposure profile of women in the study warrants a periodic biomonitoring in attempt to identify and reduce exposure to potentially dangerous elements.Isabella KarakisYael BaumfeldDaniella LandauRoni GatNofar ShemeshMaayan Yitshak-SadeOfir TiroshBatia SarovLena NovackNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabella Karakis Yael Baumfeld Daniella Landau Roni Gat Nofar Shemesh Maayan Yitshak-Sade Ofir Tirosh Batia Sarov Lena Novack Exposure to metals and morbidity at eight years follow-up in women of childbearing age
description	Abstract This exploratory study was aimed to investigate the link between toxic metal content in women’s urine and their morbidity 2 years before and 6 years after the test. Concentrations of 25 metals in urine were analyzed for 111 pregnant women collected prior to delivery. All women were of Arab-Bedouin origin. Information on primary care and hospital visits during the study period was obtained. In a Poisson regression model, a health outcome was regressed over metal exposure and other factors. A Weighted Quantile Sum Regression (WQS) approach was used to indicate metals dominating in their possible impact on women's morbidity. Obesity was the most frequently diagnosed condition in this population (27.9%). Diagnoses in a neurological category accounted for 36.0%, asthma or respiratory—25.2%, psychiatric—12.6%, cardiovascular—14.4% and cancer or benign growth—for 13.5%. Based on WQS analysis, cancer and benign growth were mostly attributed to the increased levels of cadmium, cardiovascular outcomes were linked with lead, and obesity was found associated with elevated levels of nickel. Hematological, neurological and respiratory outcomes were attributed to multiple non-essential metals. The health and exposure profile of women in the study warrants a periodic biomonitoring in attempt to identify and reduce exposure to potentially dangerous elements.
format	article
author	Isabella Karakis Yael Baumfeld Daniella Landau Roni Gat Nofar Shemesh Maayan Yitshak-Sade Ofir Tirosh Batia Sarov Lena Novack
author_facet	Isabella Karakis Yael Baumfeld Daniella Landau Roni Gat Nofar Shemesh Maayan Yitshak-Sade Ofir Tirosh Batia Sarov Lena Novack
author_sort	Isabella Karakis
title	Exposure to metals and morbidity at eight years follow-up in women of childbearing age
title_short	Exposure to metals and morbidity at eight years follow-up in women of childbearing age
title_full	Exposure to metals and morbidity at eight years follow-up in women of childbearing age
title_fullStr	Exposure to metals and morbidity at eight years follow-up in women of childbearing age
title_full_unstemmed	Exposure to metals and morbidity at eight years follow-up in women of childbearing age
title_sort	exposure to metals and morbidity at eight years follow-up in women of childbearing age
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/25f25403c0544771851c61e3f9422d2c
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Exposure to metals and morbidity at eight years follow-up in women of childbearing age

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