The Interplay between <i>Salmonella</i> and Intestinal Innate Immune Cells in Chickens

Salmonellosis is a common infection in poultry, which results in huge economic losses in the poultry industry. At the same time, <i>Salmonella</i> infections are a threat to public health, since contaminated poultry products can lead to zoonotic infections. Antibiotics as feed additives...

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Autores principales:	Adil Ijaz, Edwin J. A. Veldhuizen, Femke Broere, Victor P. M. G. Rutten, Christine A. Jansen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chicken <i>Salmonella</i> GALT innate immune cells intestine Medicine R
Acceso en línea:	https://doaj.org/article/25f2ae4438c74367ad24960f6c026ef2
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spelling	oai:doaj.org-article:25f2ae4438c74367ad24960f6c026ef22021-11-25T18:38:51ZThe Interplay between <i>Salmonella</i> and Intestinal Innate Immune Cells in Chickens10.3390/pathogens101115122076-0817https://doaj.org/article/25f2ae4438c74367ad24960f6c026ef22021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1512https://doaj.org/toc/2076-0817Salmonellosis is a common infection in poultry, which results in huge economic losses in the poultry industry. At the same time, <i>Salmonella</i> infections are a threat to public health, since contaminated poultry products can lead to zoonotic infections. Antibiotics as feed additives have proven to be an effective prophylactic option to control <i>Salmonella</i> infections, but due to resistance issues in humans and animals, the use of antimicrobials in food animals has been banned in Europe. Hence, there is an urgent need to look for alternative strategies that can protect poultry against <i>Salmonella</i> infections. One such alternative could be to strengthen the innate immune system in young chickens in order to prevent early life infections. This can be achieved by administration of immune modulating molecules that target innate immune cells, for example via feed, or by in-ovo applications. We aimed to review the innate immune system in the chicken intestine; the main site of <i>Salmonella</i> entrance, and its responsiveness to <i>Salmonella</i> infection. Identifying the most important players in the innate immune response in the intestine is a first step in designing targeted approaches for immune modulation.Adil IjazEdwin J. A. VeldhuizenFemke BroereVictor P. M. G. RuttenChristine A. JansenMDPI AGarticlechicken<i>Salmonella</i>GALTinnate immune cellsintestineMedicineRENPathogens, Vol 10, Iss 1512, p 1512 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chicken <i>Salmonella</i> GALT innate immune cells intestine Medicine R
spellingShingle	chicken <i>Salmonella</i> GALT innate immune cells intestine Medicine R Adil Ijaz Edwin J. A. Veldhuizen Femke Broere Victor P. M. G. Rutten Christine A. Jansen The Interplay between <i>Salmonella</i> and Intestinal Innate Immune Cells in Chickens
description	Salmonellosis is a common infection in poultry, which results in huge economic losses in the poultry industry. At the same time, <i>Salmonella</i> infections are a threat to public health, since contaminated poultry products can lead to zoonotic infections. Antibiotics as feed additives have proven to be an effective prophylactic option to control <i>Salmonella</i> infections, but due to resistance issues in humans and animals, the use of antimicrobials in food animals has been banned in Europe. Hence, there is an urgent need to look for alternative strategies that can protect poultry against <i>Salmonella</i> infections. One such alternative could be to strengthen the innate immune system in young chickens in order to prevent early life infections. This can be achieved by administration of immune modulating molecules that target innate immune cells, for example via feed, or by in-ovo applications. We aimed to review the innate immune system in the chicken intestine; the main site of <i>Salmonella</i> entrance, and its responsiveness to <i>Salmonella</i> infection. Identifying the most important players in the innate immune response in the intestine is a first step in designing targeted approaches for immune modulation.
format	article
author	Adil Ijaz Edwin J. A. Veldhuizen Femke Broere Victor P. M. G. Rutten Christine A. Jansen
author_facet	Adil Ijaz Edwin J. A. Veldhuizen Femke Broere Victor P. M. G. Rutten Christine A. Jansen
author_sort	Adil Ijaz
title	The Interplay between <i>Salmonella</i> and Intestinal Innate Immune Cells in Chickens
title_short	The Interplay between <i>Salmonella</i> and Intestinal Innate Immune Cells in Chickens
title_full	The Interplay between <i>Salmonella</i> and Intestinal Innate Immune Cells in Chickens
title_fullStr	The Interplay between <i>Salmonella</i> and Intestinal Innate Immune Cells in Chickens
title_full_unstemmed	The Interplay between <i>Salmonella</i> and Intestinal Innate Immune Cells in Chickens
title_sort	interplay between <i>salmonella</i> and intestinal innate immune cells in chickens
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/25f2ae4438c74367ad24960f6c026ef2
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The Interplay between <i>Salmonella</i> and Intestinal Innate Immune Cells in Chickens

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