The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis

K Binymin1,3, AL Herrick1, GL Carlson2, SJ Hopkins21University of Manchester, Rheumatic Diseases Centre, 2Infection Injury and Inflammation Group, and Brain Injury Research Group, Manchester Academic Health Science Centre and University of Manchester Faculty of Medical and Human Sciences, Salford Ro...

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Autores principales:	Binymin K, Herrick AL, Carlson GL, Hopkins SJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/25f366d67045490ab125ae119e484262
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spelling	oai:doaj.org-article:25f366d67045490ab125ae119e4842622021-12-02T00:31:54ZThe effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis1178-7031https://doaj.org/article/25f366d67045490ab125ae119e4842622011-05-01T00:00:00Zhttp://www.dovepress.com/the-effect-of-disease-activity-on-body-composition-and-resting-energy--a7505https://doaj.org/toc/1178-7031K Binymin1,3, AL Herrick1, GL Carlson2, SJ Hopkins21University of Manchester, Rheumatic Diseases Centre, 2Infection Injury and Inflammation Group, and Brain Injury Research Group, Manchester Academic Health Science Centre and University of Manchester Faculty of Medical and Human Sciences, Salford Royal Hospitals NHS Trust, Salford, UK; 3Southport District General Hospital, Southport, UKIntroduction: Cachexia is associated with rheumatoid arthritis (RA), but whether it is attributable primarily to reduced dietary intake or increased metabolism is unclear, as is the association with inflammation. To examine whether rheumatoid cachexia is related to increased energy expenditure, reduced food intake, or an inflammatory cytokine response we undertook a prospective, longitudinal study of patients with RA, during periods of relative relapse and remission of inflammation.Methods: Sixteen patients admitted to hospital with a flare of RA were assessed clinically to determine disease activity and were re-examined 6 weeks later. Their fat-free mass (FFM), dietary intake, resting energy expenditure (REE), and plasma concentrations of interleukin-6 (IL-6) were also measured. Data were compared with those from 16 healthy, age- and sex-matched controls.Results: At baseline the body weight, body mass index, and FFM of patients with RA were significantly lower than those of controls. Disease activity scores of patients (6.39 &plusmn; 0.8) were reduced when the patients were re-examined 6 weeks later (5.23 &plusmn; 1.26) and FFM was no longer statistically different from that of controls (visit 1 = 25.8 &plusmn; 10.1 and visit 2 = 26.8 &plusmn; 9.5 versus controls = 32.3 &plusmn; 10.9). There were no differences in food intake between patients and controls or between patients studied at the 2 time points, but REE was greater in patients after correcting for FMM (visit 1 = 62.2 &plusmn; 24.7, visit 2 = 59.7 &plusmn; 26.3 versus controls = 46.0 &plusmn; 13.7). Plasma IL-6 concentrations were significantly higher in patients than controls. Although IL-6 was not significantly correlated with REE, lower REE measurements were not observed when the plasma IL-6 concentration increased.Conclusion: Reduced FFM in patients with RA is not attributable to reduced food intake. Energy expenditure is greater in patients when corrected for FFM, particularly in patients with acute flares of disease activity. Although clearly not the only factor involved, increased production of IL-6 may contribute to increasing REE.Keywords: rheumatoid arthritis, cachexia, free-fat mass, fat mass, resting energy expenditure, interleukin-6Binymin KHerrick ALCarlson GLHopkins SJDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2011, Iss default, Pp 61-66 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Binymin K Herrick AL Carlson GL Hopkins SJ The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis
description	K Binymin1,3, AL Herrick1, GL Carlson2, SJ Hopkins21University of Manchester, Rheumatic Diseases Centre, 2Infection Injury and Inflammation Group, and Brain Injury Research Group, Manchester Academic Health Science Centre and University of Manchester Faculty of Medical and Human Sciences, Salford Royal Hospitals NHS Trust, Salford, UK; 3Southport District General Hospital, Southport, UKIntroduction: Cachexia is associated with rheumatoid arthritis (RA), but whether it is attributable primarily to reduced dietary intake or increased metabolism is unclear, as is the association with inflammation. To examine whether rheumatoid cachexia is related to increased energy expenditure, reduced food intake, or an inflammatory cytokine response we undertook a prospective, longitudinal study of patients with RA, during periods of relative relapse and remission of inflammation.Methods: Sixteen patients admitted to hospital with a flare of RA were assessed clinically to determine disease activity and were re-examined 6 weeks later. Their fat-free mass (FFM), dietary intake, resting energy expenditure (REE), and plasma concentrations of interleukin-6 (IL-6) were also measured. Data were compared with those from 16 healthy, age- and sex-matched controls.Results: At baseline the body weight, body mass index, and FFM of patients with RA were significantly lower than those of controls. Disease activity scores of patients (6.39 &plusmn; 0.8) were reduced when the patients were re-examined 6 weeks later (5.23 &plusmn; 1.26) and FFM was no longer statistically different from that of controls (visit 1 = 25.8 &plusmn; 10.1 and visit 2 = 26.8 &plusmn; 9.5 versus controls = 32.3 &plusmn; 10.9). There were no differences in food intake between patients and controls or between patients studied at the 2 time points, but REE was greater in patients after correcting for FMM (visit 1 = 62.2 &plusmn; 24.7, visit 2 = 59.7 &plusmn; 26.3 versus controls = 46.0 &plusmn; 13.7). Plasma IL-6 concentrations were significantly higher in patients than controls. Although IL-6 was not significantly correlated with REE, lower REE measurements were not observed when the plasma IL-6 concentration increased.Conclusion: Reduced FFM in patients with RA is not attributable to reduced food intake. Energy expenditure is greater in patients when corrected for FFM, particularly in patients with acute flares of disease activity. Although clearly not the only factor involved, increased production of IL-6 may contribute to increasing REE.Keywords: rheumatoid arthritis, cachexia, free-fat mass, fat mass, resting energy expenditure, interleukin-6
format	article
author	Binymin K Herrick AL Carlson GL Hopkins SJ
author_facet	Binymin K Herrick AL Carlson GL Hopkins SJ
author_sort	Binymin K
title	The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis
title_short	The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis
title_full	The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis
title_fullStr	The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis
title_full_unstemmed	The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis
title_sort	effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/25f366d67045490ab125ae119e484262
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The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis

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