mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3

Abstract Pterygium is one of the most common ocular surface diseases. During the initiation of pterygium, resting epithelial cells are activated and exhibit aberrant apoptosis and cell proliferation. Mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth, cell proli...

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Autores principales:	Yanli Liu, Hanchun Xu, Meixia An
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25f58fa1c0224c2f824b78ace5aefa25
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spelling	oai:doaj.org-article:25f58fa1c0224c2f824b78ace5aefa252021-12-02T11:40:44ZmTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR310.1038/s41598-017-07844-y2045-2322https://doaj.org/article/25f58fa1c0224c2f824b78ace5aefa252017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07844-yhttps://doaj.org/toc/2045-2322Abstract Pterygium is one of the most common ocular surface diseases. During the initiation of pterygium, resting epithelial cells are activated and exhibit aberrant apoptosis and cell proliferation. Mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth, cell proliferation, protein synthesis, autophagy and transcription. However, the effect of mTORC1 activation in epithelial cells on pterygium development has not yet been reported. Additionally, the roles of mTORC1 in aberrant apoptosis and cell proliferation during the initiation of pterygium, and the underlying mechanisms, are not known. Herein, we evaluated mTOR signalling in pterygium growth and development. The results revealed that mTOR signalling, especially mTORC1 signaling, is highly activated, and aberrant apoptosis and cell proliferation were observed in pterygium. mTORC1 activation inhibits apoptosis in pterygium by regulating Beclin 1-dependent autophagy via targeting Bcl-2. mTORC1 also negatively regulates fibroblast growth factor receptor 3 (FGFR3) through inhibition of p73, thereby stimulating cell proliferation in pterygium. These data demonstrate that mTORC1 signalling is highly activated in pterygium and provide new insights into the pathogenesis and progression of pterygium. Hence, mTORC1 may be a novel therapeutic target for the treatment of pterygium.Yanli LiuHanchun XuMeixia AnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanli Liu Hanchun Xu Meixia An mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3
description	Abstract Pterygium is one of the most common ocular surface diseases. During the initiation of pterygium, resting epithelial cells are activated and exhibit aberrant apoptosis and cell proliferation. Mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth, cell proliferation, protein synthesis, autophagy and transcription. However, the effect of mTORC1 activation in epithelial cells on pterygium development has not yet been reported. Additionally, the roles of mTORC1 in aberrant apoptosis and cell proliferation during the initiation of pterygium, and the underlying mechanisms, are not known. Herein, we evaluated mTOR signalling in pterygium growth and development. The results revealed that mTOR signalling, especially mTORC1 signaling, is highly activated, and aberrant apoptosis and cell proliferation were observed in pterygium. mTORC1 activation inhibits apoptosis in pterygium by regulating Beclin 1-dependent autophagy via targeting Bcl-2. mTORC1 also negatively regulates fibroblast growth factor receptor 3 (FGFR3) through inhibition of p73, thereby stimulating cell proliferation in pterygium. These data demonstrate that mTORC1 signalling is highly activated in pterygium and provide new insights into the pathogenesis and progression of pterygium. Hence, mTORC1 may be a novel therapeutic target for the treatment of pterygium.
format	article
author	Yanli Liu Hanchun Xu Meixia An
author_facet	Yanli Liu Hanchun Xu Meixia An
author_sort	Yanli Liu
title	mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3
title_short	mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3
title_full	mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3
title_fullStr	mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3
title_full_unstemmed	mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3
title_sort	mtorc1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and fgfr3
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/25f58fa1c0224c2f824b78ace5aefa25
work_keys_str_mv	AT yanliliu mtorc1regulatesapoptosisandcellproliferationinpterygiumviatargetingautophagyandfgfr3 AT hanchunxu mtorc1regulatesapoptosisandcellproliferationinpterygiumviatargetingautophagyandfgfr3 AT meixiaan mtorc1regulatesapoptosisandcellproliferationinpterygiumviatargetingautophagyandfgfr3
_version_	1718395570195791872

mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3

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