Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations.

Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations.

Somatic cells reprogrammed into induced pluripotent stem cells (iPSCs) acquire features of human embryonic stem cells (hESCs) and thus represent a promising source for cellular therapy of debilitating diseases, such as age-related disorders. However, reprogrammed cell lines have been found to harbor...

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Autores principales: Alessandro Prigione, Amir M Hossini, Björn Lichtner, Akdes Serin, Beatrix Fauler, Matthias Megges, Rudi Lurz, Hans Lehrach, Eugenia Makrantonaki, Christos C Zouboulis, James Adjaye
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/25f6d6f7499449069f6075831f408aaf
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