Cytologically indeterminate thyroid nodules: increased diagnostic performance with combination of US TI-RADS and a new scoring system
Abstract To investigate the diagnostic performance of combination of ultrasound (US) thyroid imaging reporting and data system (TI-RADS) and a new US scoring system for diagnosing thyroid nodules (TNs) with indeterminate results (Bethesda categories III, IV and V) on fine-needle aspiration (FNA) cyt...
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Nature Portfolio
2017
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oai:doaj.org-article:25f725e9e913492e8294b3ad901c26952021-12-02T15:05:13ZCytologically indeterminate thyroid nodules: increased diagnostic performance with combination of US TI-RADS and a new scoring system10.1038/s41598-017-07353-y2045-2322https://doaj.org/article/25f725e9e913492e8294b3ad901c26952017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07353-yhttps://doaj.org/toc/2045-2322Abstract To investigate the diagnostic performance of combination of ultrasound (US) thyroid imaging reporting and data system (TI-RADS) and a new US scoring system for diagnosing thyroid nodules (TNs) with indeterminate results (Bethesda categories III, IV and V) on fine-needle aspiration (FNA) cytology. 453 patients with 453 cytologically indeterminate TNs were included in this study. Multivariate analyses were performed to construct the scoring system. The diagnostic performances of TI-RADS and the combined method were evaluated and compared. Multivariate analyses revealed that marked hypoechogenicity, taller than wide shape and absence of halo sign were independent predictors for malignancy in cytologically indeterminate TNs. Scoring system was thereafter defined as follows: risk score (RS) = 3.2 x (if marked hypoechogenicity) + 2.8 x (if taller than wide shape) + 1.3 x (if absence of halo sign). Compared with TI-RADS alone, the areas under the receiver operating characteristic curves (AUC), specificity, accuracy and positive predictive value (PPV) of the combined method increased significantly with 0.731 versus 0.569, 48.5% versus 14.1%, 76.2% versus 62.3%, and 70.9% versus 59.9%, respectively (all P < 0.05). The combination of TI-RADS and new US scoring system showed superior diagnostic performances in predicting malignant TNs with indeterminate FNA cytology results in comparison with TI-RADS alone.Ya-Ping HeHui-Xiong XuChong-Ke ZhaoLi-Ping SunXiao-Long LiWen-Wen YueLe-Hang GuoDan WangWei-Wei RenQiao WangShen QuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
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Medicine R Science Q Ya-Ping He Hui-Xiong Xu Chong-Ke Zhao Li-Ping Sun Xiao-Long Li Wen-Wen Yue Le-Hang Guo Dan Wang Wei-Wei Ren Qiao Wang Shen Qu Cytologically indeterminate thyroid nodules: increased diagnostic performance with combination of US TI-RADS and a new scoring system |
| description |
Abstract To investigate the diagnostic performance of combination of ultrasound (US) thyroid imaging reporting and data system (TI-RADS) and a new US scoring system for diagnosing thyroid nodules (TNs) with indeterminate results (Bethesda categories III, IV and V) on fine-needle aspiration (FNA) cytology. 453 patients with 453 cytologically indeterminate TNs were included in this study. Multivariate analyses were performed to construct the scoring system. The diagnostic performances of TI-RADS and the combined method were evaluated and compared. Multivariate analyses revealed that marked hypoechogenicity, taller than wide shape and absence of halo sign were independent predictors for malignancy in cytologically indeterminate TNs. Scoring system was thereafter defined as follows: risk score (RS) = 3.2 x (if marked hypoechogenicity) + 2.8 x (if taller than wide shape) + 1.3 x (if absence of halo sign). Compared with TI-RADS alone, the areas under the receiver operating characteristic curves (AUC), specificity, accuracy and positive predictive value (PPV) of the combined method increased significantly with 0.731 versus 0.569, 48.5% versus 14.1%, 76.2% versus 62.3%, and 70.9% versus 59.9%, respectively (all P < 0.05). The combination of TI-RADS and new US scoring system showed superior diagnostic performances in predicting malignant TNs with indeterminate FNA cytology results in comparison with TI-RADS alone. |
| format |
article |
| author |
Ya-Ping He Hui-Xiong Xu Chong-Ke Zhao Li-Ping Sun Xiao-Long Li Wen-Wen Yue Le-Hang Guo Dan Wang Wei-Wei Ren Qiao Wang Shen Qu |
| author_facet |
Ya-Ping He Hui-Xiong Xu Chong-Ke Zhao Li-Ping Sun Xiao-Long Li Wen-Wen Yue Le-Hang Guo Dan Wang Wei-Wei Ren Qiao Wang Shen Qu |
| author_sort |
Ya-Ping He |
| title |
Cytologically indeterminate thyroid nodules: increased diagnostic performance with combination of US TI-RADS and a new scoring system |
| title_short |
Cytologically indeterminate thyroid nodules: increased diagnostic performance with combination of US TI-RADS and a new scoring system |
| title_full |
Cytologically indeterminate thyroid nodules: increased diagnostic performance with combination of US TI-RADS and a new scoring system |
| title_fullStr |
Cytologically indeterminate thyroid nodules: increased diagnostic performance with combination of US TI-RADS and a new scoring system |
| title_full_unstemmed |
Cytologically indeterminate thyroid nodules: increased diagnostic performance with combination of US TI-RADS and a new scoring system |
| title_sort |
cytologically indeterminate thyroid nodules: increased diagnostic performance with combination of us ti-rads and a new scoring system |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/25f725e9e913492e8294b3ad901c2695 |
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