Comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString.

<h4>Background</h4>Syrian hamsters infected with Andes virus (ANDV) develop a disease that recapitulates many of the salient features of human hantavirus pulmonary syndrome (HPS), including lethality. Infection of hamsters with Hantaan virus (HTNV) results in an asymptomatic, disseminate...

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Autores principales:	Rebecca L Brocato, Louis A Altamura, Brian D Carey, Casey C Perley, Candace D Blancett, Timothy D Minogue, Jay W Hooper
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/25f8804a71ba4e86b86bced1618d9b88
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spelling	oai:doaj.org-article:25f8804a71ba4e86b86bced1618d9b882021-12-02T20:23:43ZComparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString.1935-27271935-273510.1371/journal.pntd.0009592https://doaj.org/article/25f8804a71ba4e86b86bced1618d9b882021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009592https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Syrian hamsters infected with Andes virus (ANDV) develop a disease that recapitulates many of the salient features of human hantavirus pulmonary syndrome (HPS), including lethality. Infection of hamsters with Hantaan virus (HTNV) results in an asymptomatic, disseminated infection. In order to explore this dichotomy, we examined the transcriptome of ANDV- and HTNV-infected hamsters.<h4>Results</h4>Using NanoString technology, we examined kinetic transcriptional responses in whole blood collected from ANDV- and HTNV-infected hamsters. Of the 770 genes analyzed, key differences were noted in the kinetics of type I interferon sensing and signaling responses, complement activation, and apoptosis pathways between ANDV- and HTNV-infected hamsters.<h4>Conclusions</h4>Delayed activation of type I interferon responses in ANDV-infected hamsters represents a potential mechanism that ANDV uses to subvert host immune responses and enhance disease. This is the first genome-wide analysis of hantavirus-infected hamsters and provides insight into potential avenues for therapeutics to hantavirus disease.Rebecca L BrocatoLouis A AltamuraBrian D CareyCasey C PerleyCandace D BlancettTimothy D MinogueJay W HooperPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009592 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Rebecca L Brocato Louis A Altamura Brian D Carey Casey C Perley Candace D Blancett Timothy D Minogue Jay W Hooper Comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString.
description	<h4>Background</h4>Syrian hamsters infected with Andes virus (ANDV) develop a disease that recapitulates many of the salient features of human hantavirus pulmonary syndrome (HPS), including lethality. Infection of hamsters with Hantaan virus (HTNV) results in an asymptomatic, disseminated infection. In order to explore this dichotomy, we examined the transcriptome of ANDV- and HTNV-infected hamsters.<h4>Results</h4>Using NanoString technology, we examined kinetic transcriptional responses in whole blood collected from ANDV- and HTNV-infected hamsters. Of the 770 genes analyzed, key differences were noted in the kinetics of type I interferon sensing and signaling responses, complement activation, and apoptosis pathways between ANDV- and HTNV-infected hamsters.<h4>Conclusions</h4>Delayed activation of type I interferon responses in ANDV-infected hamsters represents a potential mechanism that ANDV uses to subvert host immune responses and enhance disease. This is the first genome-wide analysis of hantavirus-infected hamsters and provides insight into potential avenues for therapeutics to hantavirus disease.
format	article
author	Rebecca L Brocato Louis A Altamura Brian D Carey Casey C Perley Candace D Blancett Timothy D Minogue Jay W Hooper
author_facet	Rebecca L Brocato Louis A Altamura Brian D Carey Casey C Perley Candace D Blancett Timothy D Minogue Jay W Hooper
author_sort	Rebecca L Brocato
title	Comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString.
title_short	Comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString.
title_full	Comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString.
title_fullStr	Comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString.
title_full_unstemmed	Comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString.
title_sort	comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in syrian hamsters using nanostring.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/25f8804a71ba4e86b86bced1618d9b88
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_version_	1718374096595582976

Comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString.

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